Misjudgement of gefitinib efficacy in patients with central non-small‑cell lung cancer due to obstructive atelectasis caused by stereotactic radiotherapy

Yang,Xueqin; Xiong,Yanli; Huang,Huan; Peng,Bo; Zhou,Zejun; Xu,Mingfang; Yang,Yi; Wang,Dong

doi:10.3892/mco.2014.284

July-August 2014 Volume 2 Issue 4

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July-August 2014 Volume 2 Issue 4

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Article

Misjudgement of gefitinib efficacy in patients with central non-small‑cell lung cancer due to obstructive atelectasis caused by stereotactic radiotherapy

Authors:
- Xueqin Yang
- Yanli Xiong
- Huan Huang
- Bo Peng
- Zejun Zhou
- Mingfang Xu
- Yi Yang
- Dong Wang
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Affiliations: Cancer Center, Daping Hospital, Third Military Medical University, Daping, Yuzhong, Chongqing 400042, P.R. China
Pages: 535-538
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Published online on: April 30, 2014

https://doi.org/10.3892/mco.2014.284
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Abstract

Stereotactic body radiation therapy (SBRT) has been reported to be safe and effective for the treatment of central lung cancer, with mostly tolerable early complications. In this study, we report the development of severe obstructive atelectasis as a late complication in two patients with central lung cancer who received SBRT. This obstructive atelectasis interrupted the evaluation of efficacy of the subsequent gefitinib treatment for non-small‑cell lung cancer (NSCLC). The two patients received a total dose of 40 Gy encompassing the planning target volume in 10 fractions (5 fractions̸week) at 4 Gy per fraction at the central lesions. Obstructive atelectasis occurred when the patients received subsequent gefitinib treatment. Follow-up reviews or positron emission tomography-computed tomography examination of the two patients confirmed that obstructive atelectasis was actually caused by radiotherapy rather than disease progression. Misjudgement of the cause of ostructive atelectasis in one of the cases resulted in premature termination of gefitinib. Therefore, it is crucial to accurately determine the cause of late complications in NSCLC patients receiving sequential SBRT and gefitinib.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Misjudgement of gefitinib efficacy in patients with central non-small‑cell lung cancer due to obstructive atelectasis caused by stereotactic radiotherapy

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