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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Differences in carcinoembryonic antigen levels between colon and rectal cancer

  • Authors:
    • Yunlong Ding
    • Weibo Xuan
    • Chunlin Chen
    • Zhe Chen
    • Ziyi Yang
    • Yunfei Zuo
    • Shuangyi Ren
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
  • Pages: 618-622
    |
    Published online on: April 30, 2014
       https://doi.org/10.3892/mco.2014.286
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Abstract

The aim of the present study was to investigate the levels of the serum tumor biomarker carcinoembryonic antigen (CEA) in patients with carcinoma of the colon and rectum in different clinical stages. Colorectal cancer (CRC) is one of the most commonly diagnosed types of cancer worldwide and previous studies have reported rapidly updated therapeutic regimes. While the majority of studies focus on CRC as a single entity, certain studies distinguish colon cancer (CC) from rectal cancer (RC), as there is a hypothesis stating that CC and RC are two naturally different entities. CEA is reported to be an important tumor‑associated antigen overexpressed in CRC, which is routinely detected as a significant indicator of CRC. Our study aimed to identify potential differences in the expression of CEA between CC and RC, which may, to some degree, reflect the natural differences between the two. We investigated 261 CRC cases between July, 2010 and December, 2012 from The First and Second Affiliated Hospitals of Dalian Medical University, including 129 CC and 132 RC patients with tumors classified by Duke's staging as A‑D. The serum CEA level was measured preoperatively by radioimmunoassays as a routinely used auxiliary indicator. The expression of CEA differed between CC and RC, with the former exhibiting variation among the four stages, whereas no variation was observed in RC. In addition, there were differences between CC and RC regarding the CEA level in stage C and D. Furthermore, the CEA level in stage C of CC was significantly lower compared to that in any other stage. In conclusion, the intrinsic distribution of the CEA level between CC and RC suggests that CC and RC may be two naturally different entities; the significantly low CEA level in stage C of CC indicates that stage C may be crucial in the evolution of CC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2 

Wakai K, Hirose K, Matsuo K, Ito H, Kuriki K, Suzuki T, Kato T, Hirai T, Kanemitsu Y and Tajima K: Dietary risk factors for colon and rectal cancers: a comparative case-control study. J Epidemiol. 16:125–135. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Mayer RJ, Garnick MB, Steele GD Jr and Zamcheck N: Carcinoembryonic antigen (CEA) as a monitor of chemotherapy in disseminated colorectal cancer. Cancer. 42(Suppl 3): 1428–1433. 1978. View Article : Google Scholar : PubMed/NCBI

5 

Petrioli R, Licchetta A, Roviello G, et al: CEA and CA19.9 as early predictors of progression in advanced/metastatic colorectal cancer patients receiving oxaliplatin-based chemotherapy and bevacizumab. Cancer Invest. 30:65–71. 2012. View Article : Google Scholar

6 

Gold P and Freedman SO: Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 122:467–481. 1965. View Article : Google Scholar : PubMed/NCBI

7 

Shuster J, Thomson DM, Fuks A and Gold P: Immunologic approaches to diagnosis of malignancy. Prog Exp Tumor Res. 25:89–139. 1980.

8 

Shively JE and Beatty JD: CEA-related antigens: molecular biology and clinical significance. Crit Rev Oncol Hematol. 2:355–399. 1985. View Article : Google Scholar : PubMed/NCBI

9 

Hefta LJ, Neumaier M and Shively JE: Kinetic and affinity constants of epitope specific anti-carcinoembryonic antigen (CEA) monoclonal antibodies for CEA and engineered CEA domain constructs. Immunotechnology. 4:49–57. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Kojima T, Yoshikawa K, Matsui T, Kodera Y and Kojima H: Titration of serum CEA, p53 antibodies and CEA-IgM complexes in patients with colorectal cancer. Mol Med Rep. 2:477–480. 2009.PubMed/NCBI

11 

Edge SB and Compton CC: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Chen CC, Yang SH, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS and Chang SC: Is it reasonable to add preoperative serum level of CEA and CA19-9 to staging for colorectal cancer? J Surg Res. 124:169–174. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Midiri G, Amanti C, Consorti F, Benedetti M, Del Buono S, Di Tondo U, Castagna G, Peronace L and Di Paola M: Usefulness of preoperative CEA levels in the assessment of colorectal cancer patient stage. J Surg Oncol. 22:257–260. 1983. View Article : Google Scholar : PubMed/NCBI

14 

Pasanen PA, Eskelinen M, Partanen K, Pikkarainen P, Penttila I and Alhava E: Clinical value of serum tumour markers CEA, CA 50 and CA 242 in the distinction between malignant versus benign diseases causing jaundice and cholestasis; results from a prospective study. Anticancer Res. 12:1687–1693. 1992.

15 

Lin JK, Lin CC, Yang SH, Wang HS, Jiang JK, Lan YT, Lin TC, Li AF, Chen WS and Chang SC: Early postoperative CEA level is a better prognostic indicator than is preoperative CEA level in predicting prognosis of patients with curable colorectal cancer. Int J Colorectal Dis. 26:1135–1141. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Li M, Li JY, Zhao AL and Gu J: Colorectal cancer or colon and rectal cancer? Clinicopathological comparison between colonic and rectal carcinomas. Oncology. 73:52–57. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Nielsen HJ, Brunner N, Jorgensen LN, et al: Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals. Scand J Gastroenterol. 46:60–69. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Lee WS, Baek JH, Kim KK and Park YH: The prognostic significant of percentage drop in serum CEA post curative resection for colon cancer. Surg Oncol. 21:45–51. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Hashiguchi Y, Hase K, Ueno H, Mochizuki H, Kajiwara Y, Ichikura T and Yamamoto J: Prognostic significance of the number of lymph nodes examined in colon cancer surgery: clinical application beyond simple measurement. Ann Surg. 251:872–881. 2010. View Article : Google Scholar

20 

Elias E, Mukherji D, Faraj W, Khalife M, Dimassi H, Eloubeidi M, Hattoum H, Abou-Alfa GK, Saleh A and Shamseddine A: Lymph-node ratio is an independent prognostic factor in patients with stage III colorectal cancer: a retrospective study from the Middle East. World J Surg Oncol. 10:632012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding Y, Xuan W, Chen C, Chen Z, Yang Z, Zuo Y and Ren S: Differences in carcinoembryonic antigen levels between colon and rectal cancer. Mol Clin Oncol 2: 618-622, 2014.
APA
Ding, Y., Xuan, W., Chen, C., Chen, Z., Yang, Z., Zuo, Y., & Ren, S. (2014). Differences in carcinoembryonic antigen levels between colon and rectal cancer. Molecular and Clinical Oncology, 2, 618-622. https://doi.org/10.3892/mco.2014.286
MLA
Ding, Y., Xuan, W., Chen, C., Chen, Z., Yang, Z., Zuo, Y., Ren, S."Differences in carcinoembryonic antigen levels between colon and rectal cancer". Molecular and Clinical Oncology 2.4 (2014): 618-622.
Chicago
Ding, Y., Xuan, W., Chen, C., Chen, Z., Yang, Z., Zuo, Y., Ren, S."Differences in carcinoembryonic antigen levels between colon and rectal cancer". Molecular and Clinical Oncology 2, no. 4 (2014): 618-622. https://doi.org/10.3892/mco.2014.286
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y, Xuan W, Chen C, Chen Z, Yang Z, Zuo Y and Ren S: Differences in carcinoembryonic antigen levels between colon and rectal cancer. Mol Clin Oncol 2: 618-622, 2014.
APA
Ding, Y., Xuan, W., Chen, C., Chen, Z., Yang, Z., Zuo, Y., & Ren, S. (2014). Differences in carcinoembryonic antigen levels between colon and rectal cancer. Molecular and Clinical Oncology, 2, 618-622. https://doi.org/10.3892/mco.2014.286
MLA
Ding, Y., Xuan, W., Chen, C., Chen, Z., Yang, Z., Zuo, Y., Ren, S."Differences in carcinoembryonic antigen levels between colon and rectal cancer". Molecular and Clinical Oncology 2.4 (2014): 618-622.
Chicago
Ding, Y., Xuan, W., Chen, C., Chen, Z., Yang, Z., Zuo, Y., Ren, S."Differences in carcinoembryonic antigen levels between colon and rectal cancer". Molecular and Clinical Oncology 2, no. 4 (2014): 618-622. https://doi.org/10.3892/mco.2014.286
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