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Molecular and Clinical Oncology
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July-August 2014 Volume 2 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma

  • Authors:
    • Masashi Shiiba
    • Motoharu Unozawa
    • Morihiro Higo
    • Yukinao Kouzu
    • Atsushi Kasamatsu
    • Yosuke Sakamoto
    • Katsunori Ogawara
    • Katsuhiro Uzawa
    • Yuichi Takiguchi
    • Hideki Tanzawa
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan, Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba 260‑8670, Japan
  • Pages: 609-617
    |
    Published online on: May 8, 2014
       https://doi.org/10.3892/mco.2014.291
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Abstract

The objective of this study was to elucidate the clinical characteristics of uncommon head and neck malignancies, such as non‑squamous cell carcinoma (SCC), in order to improve patient outcomes. A total of 463 head and neck malignancies were retrospectively analyzed, with 43 cases (9.3%) diagnosed as non‑SCC. The overall survival rate of patients with adenoid cystic carcinoma was significantly worse compared to that of patients with SCC. The 5‑year survival rates were <50% for patients with malignant melanoma, adenocarcinoma, small‑cell carcinoma and sarcomas. Distant metastasis to the lung was frequently observed in cases with a poor outcome. non‑SCC malignancies treated without surgery were associated with a worse outcome. Some non‑SCC patients had a poor prognosis and distant metastasis was associated with an unsatisfactory outcome. Timely treatment and control of distant metastasis are essential and surgical treatment should be prioritized in non‑SCC cases to improve patient outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Shiiba M, Unozawa M, Higo M, Kouzu Y, Kasamatsu A, Sakamoto Y, Ogawara K, Uzawa K, Takiguchi Y, Tanzawa H, Tanzawa H, et al: Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma. Mol Clin Oncol 2: 609-617, 2014.
APA
Shiiba, M., Unozawa, M., Higo, M., Kouzu, Y., Kasamatsu, A., Sakamoto, Y. ... Tanzawa, H. (2014). Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma. Molecular and Clinical Oncology, 2, 609-617. https://doi.org/10.3892/mco.2014.291
MLA
Shiiba, M., Unozawa, M., Higo, M., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Uzawa, K., Takiguchi, Y., Tanzawa, H."Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma". Molecular and Clinical Oncology 2.4 (2014): 609-617.
Chicago
Shiiba, M., Unozawa, M., Higo, M., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Uzawa, K., Takiguchi, Y., Tanzawa, H."Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 609-617. https://doi.org/10.3892/mco.2014.291
Copy and paste a formatted citation
x
Spandidos Publications style
Shiiba M, Unozawa M, Higo M, Kouzu Y, Kasamatsu A, Sakamoto Y, Ogawara K, Uzawa K, Takiguchi Y, Tanzawa H, Tanzawa H, et al: Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma. Mol Clin Oncol 2: 609-617, 2014.
APA
Shiiba, M., Unozawa, M., Higo, M., Kouzu, Y., Kasamatsu, A., Sakamoto, Y. ... Tanzawa, H. (2014). Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma. Molecular and Clinical Oncology, 2, 609-617. https://doi.org/10.3892/mco.2014.291
MLA
Shiiba, M., Unozawa, M., Higo, M., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Uzawa, K., Takiguchi, Y., Tanzawa, H."Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma". Molecular and Clinical Oncology 2.4 (2014): 609-617.
Chicago
Shiiba, M., Unozawa, M., Higo, M., Kouzu, Y., Kasamatsu, A., Sakamoto, Y., Ogawara, K., Uzawa, K., Takiguchi, Y., Tanzawa, H."Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non‑squamous cell carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 609-617. https://doi.org/10.3892/mco.2014.291
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