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Article

GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma

  • Authors:
    • Wey‑Ran Lin
    • Chao‑Wei Hsu
    • Yi‑Cheng Chen
    • Ming‑Ling Chang
    • Kung‑Hao Liang
    • Ya‑Hui Huang
    • Chau‑Ting Yeh
  • View Affiliations / Copyright

    Affiliations: Liver Research Center, Department of Hepato‑Gastroenterology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan, R.O.C.
  • Pages: 630-640
    |
    Published online on: May 15, 2014
       https://doi.org/10.3892/mco.2014.294
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Abstract

In addition to targeted agents, chemotherapy is currently considered to be a treatment option for patients with advanced hepatocellular carcinoma (HCC); however, it is associated with severe side effects that may limit its clinical use. UDP‑N‑acetyl‑α‑D‑galactosamine:polypeptide N‑acetyl‑galactosaminyltransferase 14 (GALNT14) genotype was previously identified as a prognostic marker for HCC patients receiving 5‑fluorouracil, mitoxantrone and cisplatin (FMP) combination chemotherapy. The present study aimed to assess clinical parameters and on‑treatment side effects as effective predictors for favorable prognosis. A total of 118 patients with HCC receiving split‑dose FMP were retrospectively enrolled. The clinical parameters, side effects and GALNT14 genotype were analyzed. The independent predictors for time‑to‑progression (TTP) and overall survival (OS) were assessed using Cox proportional hazards models. Following categorization, the Kaplan‑Meier method was used to compare survival outcomes. Pretreatment α‑fetoprotein (AFP) ≤2,800 ng/ml (median level), GALNT14 ‘TT’ genotype, on‑treatment leukopenia and absence of vomiting were identified as independent predictors of a favorable TTP (P=0.001, 0.035, 0.008 and 0.009, respectively) and OS (P=0.028, 0.006, 0.027 and 0.013, respectively). A total of 59 patients with AFP ≤2,800 ng̸ml exhibited longer median TTP and OS (3.11 vs. 1.75 months, P<0.001; and 8.14 vs. 3.79 months, P<0.001, respectively). A total of 30 patients with the GALNT14 ‘TT’ genotype exhibited longer median TTP and OS (3.11 vs. 2.11 months, P=0.014; and 5.75 vs. 3.93 months, P=0.001, respectively). Finally, 9 patients (9/118; 7.6%) with all four favorable factors exhibited the longest median TTP and OS (10.64 vs. 2.07 months, P=0.002; and 25.50 vs. 4.50 months, P<0.001, respectively). In conclusion, the AFP level and the GALNT genotype may be considered as pre‑therapeutic predictors of a favorable response. When combined with on‑treatment leukopenia and absence of vomiting, a subgroup of patients with excellent outcome may be identified.
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1 

Llovet JM, Brú C and Bruix J: Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 19:329–338. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Villanueva A, Hernandez-Gea V and Llovet JM: Medical therapies for hepatocellular carcinoma: a critical view of the evidence. Nat Rev Gastroenterol Hepatol. 10:34–42. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Bruix J and Sherman M; American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology. 53:1020–1022. 2011. View Article : Google Scholar : PubMed/NCBI

4 

European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 56:908–943. 2012.PubMed/NCBI

5 

Llovet JM, Ricci S, Mazzaferro V, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Cheng AL, Kang YK, Chen Z, et al: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10:25–34. 2009. View Article : Google Scholar

7 

Abou-Alfa GK, Amadori D, Santoro A, et al: Safety and efficacy of sorafenib in patients with hepatocellular carcinoma (HCC) and Child-Pugh A versus B cirrhosis. Gastrointest Cancer Res. 4:40–44. 2011.PubMed/NCBI

8 

Chiu J, Tang YF, Yao TJ, et al: The use of single-agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child-Pugh B liver cirrhosis: a retrospective analysis of efficacy, safety, and survival benefits. Cancer. 118:5293–5301. 2012. View Article : Google Scholar

9 

Kim HY, Park JW, Joo J, et al: Worse outcome of sorafenib therapy associated with ascites and Child-Pugh score in advanced hepatocellular carcinoma. J Gastroenterol Hepatol. 28:1756–1761. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Pressiani T, Boni C, Rimassa L, et al: Sorafenib in patients with Child-Pugh class A and B advanced hepatocellular carcinoma: a prospective feasibility analysis. Ann Oncol. 24:406–411. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zhu AX: Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be? Oncologist. 11:790–800. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Yang TS, Chang HK, Chen JS, Lin YC, Liau CT and Chang WC: Chemotherapy using 5-fluorouracil, mitoxantrone, and cisplatin for patients with advanced hepatocellular carcinoma: an analysis of 63 cases. J Gastroenterol. 39:362–369. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Liang KH, Lin CC and Yeh CT: GALNT14 SNP as a potential predictor of response to combination chemotherapy using 5-FU, mitoxantrone and cisplatin in advanced HCC. Pharmacogenomics. 12:1061–1073. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Yeh CT, Chen HC, Sung CM, et al: Retrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma. BMC Cancer. 11:1172011. View Article : Google Scholar

15 

Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL and Hung CF: A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma. Int J Cancer. 134:1214–1224. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Oken MM, Creech RH, Tormey DC, et al: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

17 

Trotti A, Colevas AD, Setser A, et al: CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 13:176–181. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Liu C, Xiao GQ, Yan LN, et al: Value of α-fetoprotein in association with clinicopathological features of hepatocellular carcinoma. World J Gastroenterol. 19:1811–1819. 2013.

19 

Tangkijvanich P1, Anukulkarnkusol N, Suwangool P, et al: Clinical characteristics and prognosis of hepatocellular carcinoma: analysis based on serum alpha-fetoprotein levels. J Clin Gastroenterol. 31:302–308. 2000. View Article : Google Scholar

20 

Ma WJ, Wang HY and Teng LS: Correlation analysis of preoperative serum alpha-fetoprotein (AFP) level and prognosis of hepatocellular carcinoma (HCC) after hepatectomy. World J Surg Oncol. 11:2122013. View Article : Google Scholar : PubMed/NCBI

21 

Chang SK, Hlaing WW, Yu RQ, Lee TW, Ganpathi IS and Madhavan KK: Value of alpha-foetoprotein for screening of recurrence in hepatocellular carcinoma post resection. Singapore Med J. 53:32–35. 2012.PubMed/NCBI

22 

Lee YK, Kim SU, Kim do Y, et al: Prognostic value of α-fetoprotein and des-γ-carboxy prothrombin responses in patients with hepatocellular carcinoma treated with transarterial chemoembolization. BMC Cancer. 13:52013.

23 

Personeni N, Bozzarelli S, Pressiani T, et al: Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma. J Hepatol. 57:101–107. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Memon K, Kulik L, Lewandowski RJ, et al: Alpha-fetoprotein response correlates with EASL response and survival in solitary hepatocellular carcinoma treated with transarterial therapies: a subgroup analysis. J Hepatol. 56:1112–1120. 2012. View Article : Google Scholar

25 

Lee MH, Kim SU, Kim do Y, et al: Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma. J Gastroenterol Hepatol. 27:313–322. 2012. View Article : Google Scholar

26 

Nakazawa T, Hidaka H, Takada J, et al: Early increase in α-fetoprotein for predicting unfavorable clinical outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib. Eur J Gastroenterol Hepatol. 25:683–689. 2013.

27 

Patt YZ, Yoffe B, Charnsangavej C, et al: Low serum alpha-fetoprotein level in patients with hepatocellular carcinoma as a predictor of response to 5-FU and interferon-alpha-2b. Cancer. 72:2574–2582. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Li MS, Ma QL, Chen Q, et al: Alpha-fetoprotein triggers hepatoma cells escaping from immune surveillance through altering the expression of Fas/FasL and tumor necrosis factor related apoptosis-inducing ligand and its receptor of lymphocytes and liver cancer cells. World J Gastroenterol. 11:2564–2569. 2005. View Article : Google Scholar

29 

Iida H, Honda M, Kawai HF, et al: Ephrin-A1 expression contributes to the malignant characteristics of {alpha}-fetoprotein producing hepatocellular carcinoma. Gut. 54:843–851. 2005.PubMed/NCBI

30 

Lee CK, Simes RJ, Brown C, et al: Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer. Br J Cancer. 105:1144–1150. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Shitara K, Matsuo K, Takahari D, et al: Neutropenia as a prognostic factor in advanced gastric cancer patients undergoing second-line chemotherapy with weekly paclitaxel. Ann Oncol. 21:2403–2409. 2010. View Article : Google Scholar

32 

Shitara K, Matsuo K, Takahari D, et al: Neutropaenia as a prognostic factor in metastatic colorectal cancer patients undergoing chemotherapy with first-line FOLFOX. Eur J Cancer. 45:1757–1763. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Pallis AG, Agelaki S, Kakolyris S, et al: Chemotherapy-induced neutropenia as a prognostic factor in patients with advanced non-small cell lung cancer treated with front-line docetaxel-gemcitabine chemotherapy. Lung Cancer. 62:356–363. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Koutras AK, Fountzilas G, Dafni U, et al; Hellenic Cooperative Oncology Group. Myelotoxicity as a prognostic factor in patients with advanced breast cancer treated with chemotherapy: a pooled analysis of two randomised trials conducted by the Hellenic Cooperative Oncology Group. Anticancer Res. 28:2913–2920. 2008.

35 

Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y and Fukushima M: Predictive value of chemotherapy-induced neutropenia for the efficacy of oral fluoropyrimidine S-1 in advanced gastric carcinoma. Br J Cancer. 97:37–42. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Di Maio M, Gridelli C, Gallo C, et al: Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials. Lancet Oncol. 6:669–677. 2005.PubMed/NCBI

37 

Poikonen P, Saarto T, Lundin J, Joensuu H and Blomqvist C: Leucocyte nadir as a marker for chemotherapy efficacy in node-positive breast cancer treated with adjuvant CMF. Br J Cancer. 80:1763–1766. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Saarto T, Blomqvist C, Rissanen P, Auvinen A and Elomaa I: Haematological toxicity: a marker of adjuvant chemotherapy efficacy in stage II and III breast cancer. Br J Cancer. 75:301–305. 1997. View Article : Google Scholar : PubMed/NCBI

39 

Shitara K, Matsuo K, Oze I, et al: Meta-analysis of neutropenia or leukopenia as a prognostic factor in patients with malignant disease undergoing chemotherapy. Cancer Chemother Pharmacol. 68:301–307. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Lagman RL, Davis MP, LeGrand SB and Walsh D: Common symptoms in advanced cancer. Surg Clin North Am. 85:237–255. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH and Yeh CT: GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma. Mol Clin Oncol 2: 630-640, 2014.
APA
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., & Yeh, C. (2014). GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma. Molecular and Clinical Oncology, 2, 630-640. https://doi.org/10.3892/mco.2014.294
MLA
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., Yeh, C."GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma". Molecular and Clinical Oncology 2.4 (2014): 630-640.
Chicago
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., Yeh, C."GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 630-640. https://doi.org/10.3892/mco.2014.294
Copy and paste a formatted citation
x
Spandidos Publications style
Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH and Yeh CT: GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma. Mol Clin Oncol 2: 630-640, 2014.
APA
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., & Yeh, C. (2014). GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma. Molecular and Clinical Oncology, 2, 630-640. https://doi.org/10.3892/mco.2014.294
MLA
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., Yeh, C."GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma". Molecular and Clinical Oncology 2.4 (2014): 630-640.
Chicago
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., Yeh, C."GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 630-640. https://doi.org/10.3892/mco.2014.294
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