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Article

Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma

  • Authors:
    • Michael Schmitt
    • Rudolf Trenschel
    • Herbert G. Sayer
    • Catarina Schneider
    • Aenne Glass
    • Inken Hilgendorf
    • Anne Treschl
    • Christian Junghanss
    • Kersten Borchert
    • Michael Koenigsmann
    • Jochen Casper
    • Dietrich W. Beelen
    • Mathias Freund
    • Christoph Kahl
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine III, University of Rostock, Rostock 18057, Germany, Department of Bone Marrow Transplantation, University of Duisburg‑Essen, Essen 45147, Germany, Department of Hematology and Oncology, University of Jena, Jena 07747, Germany, Institute for Biostatistics and Informatics in Medicine and Ageing Research, University of Rostock, Rostock 18057, Germany, Department of Hematology and Oncology, University of Magdeburg, Magdeburg 39120, Germany
  • Pages: 773-782
    |
    Published online on: June 2, 2014
       https://doi.org/10.3892/mco.2014.300
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Abstract

The treatment of refractory or relapsed non‑Hodgkin lymphoma (NHL) remains challenging. In this retrospective study, 88 patients with refractory or relapsed NHL received treosulfan and fludarabine as a reduced‑intensity conditioning for allogeneic hematopoietic stem cell transplantation (allo‑HSCT). Of the 88 intensely pre‑treated patients, 73 experienced a relapse, with 18 of the 88 patients experiencing an early relapse (ER; <6 months from the last chemotherapy). At the time of allo‑HSCT, 26 patients were in complete remission (CR) and 43 in partial remission (PR), 12 patients had progressive disease (PD) and 7 had stable disease (SD). A total of 47 patients received an autologous graft followed by allo‑HSCT. Following allo‑HSCT, 69 of the 88 patients were in CR and 7 were in PR, resulting in an overall response rate of 86.4% (76/88). A total of 33 patients achieved a CR from PR, as did 6 patients from PD and 5 from SD. Of the 88 patients, 43 (49%) were alive at the end of the follow‑up period. The patients who directly underwent allo‑HSCT without prior auto‑HSCT exhibited a better disease‑free survival (DFS; P=0.038) with a tendency (P=0.077) for a better overall survival (OS). The patients with ER exhibited a probability of OS of 0.35±0.12 after 3 and 7 years. Chronic graft‑versus‑host disease (cGvHD) exerted a positive effect on OS and DFS (for limited cGvHD vs. no cGvHD, P=0.002 and 0.004, respectively). In conclusion, allogeneic stem cell transplantation following conditioning with treosufan and fludarabine constitutes a viable therapeutic option for patients with refractory or relapsed NHL and should be considered early during the course of salvage treatment.
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1 

Verdonck LF, van Putten WL, Hagenbeek A, et al: Comparison of CHOP chemotherapy with autologous bone marrow transplantation for slowly responding patients with aggressive non-Hodgkin’s lymphoma. N Engl J Med. 332:1045–1051. 1995.PubMed/NCBI

2 

Chen AI, McMillan A, Negrin RS, et al: Long-term results of autologous hematopoietic cell transplantation for peripheral T cell lymphoma: the Stanford experience. Biol Blood Marrow Transplant. 14:741–747. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Hamadani M, Benson DM Jr, Lin TS, et al: High-dose therapy and autologous stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma. Eur J Haematol. 81:425–431. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Koenigsmann M, Casper J, Kahl C, et al: Risk-adapted, treosulfan-based therapy with auto- and allo-SCT for relapsed/refractory aggressive NHL: a prospective phase-II trial. Bone Marrow Transplant. 49:410–415. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Bishop MR, Dean RM, Steinberg SM, et al: Correlation of pretransplant and early post-transplant response assessment with outcomes after reduced-intensity allogeneic hematopoietic stem cell transplantation for non-Hodgkin’s lymphoma. Cancer. 116:852–862. 2010.PubMed/NCBI

6 

Hamadani M, Benson DM Jr, Hofmeister CC, et al: Allogeneic stem cell transplantation for patients with relapsed chemorefractory aggressive non-Hodgkin lymphomas. Biol Blood Marrow Transplant. 15:547–553. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Casper J, Knauf W, Kiefer T, et al: Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation. Blood. 103:725–731. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Schmidt-Hieber M, Blau IW, Trenschel R, et al: Reduced-toxicity conditioning with fludarabine and treosulfan prior to allogeneic stem cell transplantation in multiple myeloma. Bone Marrow Transplant. 39:389–396. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Casper J, Wolff D, Knauf W, et al: Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning. J Clin Oncol. 28:3344–3351. 2010. View Article : Google Scholar

10 

Hilgendorf I, Wolff D, Gromke T, et al: Retrospective analysis of treosulfan-based conditioning in comparison with standard conditioning in patients with myelodysplastic syndrome. Bone Marrow Transplant. 46:502–509. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Cheson BD, Horning SJ, Coiffier B, et al: Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. NCI Sponsored International Working Group. J Clin Oncol. 17:12441999.PubMed/NCBI

12 

Cutler C and Antin JH: Manifestations and treatment of acute graft-versus-host disease. Thomas’ Hematopoetic Cell Transplantation. Appelbaum FR, Forman SJ, Negrin RS and Blume KG: 4th edition. Willey-Blackwell; London: pp. 1287–1303. 2009

13 

Lee SJ, Vogelsang G and Flowers ME: Chronic graft-versus-host disease. Biol Blood Marrow Transplant. 9:215–233. 2003. View Article : Google Scholar : PubMed/NCBI

14 

El Gnaoui T, Dupuis J, Belhadj K, et al: Rituximab, gemcitabine and oxaliplatin: an effective salvage regimen for patients with relapsed or refractory B-cell lymphoma not candidates for high-dose therapy. Ann Oncol. 18:1363–1368. 2007.PubMed/NCBI

15 

Martin A, Conde E, Arnan M, et al; GEL/TAMO Cooperative Group. R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. A GEL/TAMO study. Haematologica. 93:1829–1836. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Le Gouill S, Milpied N, Buzyn A, et al: Société Française de Greffe de Moëlle et de Thérapie Cellulaire: Graft-versus-lymphoma effect for aggressive T-cell lymphomas in adults: a study by the Societé Française de Greffe de Moëlle et de Thérapie Cellulaire. J Clin Oncol. 26:2264–2271. 2008.

17 

Khouri IF, McLaughlin P, Saliba RM, et al: Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab. Blood. 111:5530–5536. 2008.

18 

Dietrich S, Tielesch B, Rieger M, et al: Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma. Cancer. 117:1901–1910. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Chopra R, Goldstone AH, Pearce R, et al: Autologous versus allogeneic bone marrow transplantation for non-Hodgkin’s lymphoma: a case-controlled analysis of the European Bone Marrow Transplant Group Registry data. J Clin Oncol. 10:1690–1695. 1992.

20 

Peniket AJ, Ruiz de Elvira MC, Taghipour G, et al: European Bone Marrow Transplantation (EBMT) Lymphoma Registry: An EBMT registry matched study of allogeneic stem cell transplants for lymphoma: allogeneic transplantation is associated with a lower relapse rate but a higher procedure-related mortality rate than autologous transplantation. Bone Marrow Transplant. 31:667–678. 2003.

21 

Bierman PJ, Sweetenham JW, Loberiza FR, et al: Lymphoma Working Committee of the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation: Syngeneic hematopoietic stem-cell transplantation for non-Hodgkin’s lymphoma: a comparison with allogeneic and autologous transplantation - The Lymphoma Working Committee of the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation. J Clin Oncol. 21:3744–3753. 2003.PubMed/NCBI

22 

McSweeney PA, Niederweiser D, Shizuru JA, et al: Hemapoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood. 97:3390–3400. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Khouri IF, Saliba RM, Giralt SA, et al: Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality. Blood. 98:3595–3599. 2001. View Article : Google Scholar

24 

Escalon MP, Champlin RE, Saliba RM, et al: Nonmyeloablative allogeneic hematopoietic transplantation: a promising salvage therapy for patients with non-Hodgkin’s lymphoma whose disease has failed a prior autologous transplantation. J Clin Oncol. 22:2419–2423. 2004.PubMed/NCBI

25 

Rezvani AR, Storer B, Maris M, et al: Nonmyeloablative allogeneic hematopoietic cell transplantation in relapsed, refractory, and transformed indolent non-Hodgkin’s lymphoma. J Clin Oncol. 26:211–217. 2008.PubMed/NCBI

26 

Glass B, Nickelsen M, Dreger P, et al: Reduced-intensity conditioning prior to allogeneic transplantation of hematopoietic stem cells: the need for T cells early after transplantation to induce a graft-versus-lymphoma effect. Bone Marrow Transplant. 34:391–397. 2004. View Article : Google Scholar

27 

Beelen DW, Trenschel R, Casper J, et al: Dose-escalated treosulphan in combination with cyclophosphamide as a new preparative regimen for allogeneic hematopoietic stem cell transplantation in patients with an increased risk for regimen-related complications. Bone Marrow Transplant. 35:233–241. 2005. View Article : Google Scholar

28 

Scheulen ME, Hilger RA, Oberhoff C, et al: Clinical phase I dose escalation and pharmacokinetic study of high-dose chemotherapy with treosulfan and autologous peripheral blood stem cell transplantation in patients with advanced malignancies. Clin Cancer Res. 6:4209–4216. 2000.

29 

Banna GL, Aversa S, Sileni VC, et al: Nonmyeloablative allogeneic stem cell transplantation (NST) after truly nonmyeloablative and reduced intensity conditioning regimens. Crit Rev Oncol Hematol. 51:171–189. 2004. View Article : Google Scholar

30 

Schetelig J, Bornhauser M, Kiehl M, et al: Reduced-intensity conditioning with busulfan and fludarabine with or without antithymocyte globulin in HLA-identical sibling tranplantation - a retrospective analysis. Bone Marrow Transplant. 33:483–490. 2004. View Article : Google Scholar

31 

Slavin S, Nagler A, Naparstek E, et al: Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood. 91:756–763. 1998.

32 

Robinson SP, Goldstone AH, Mackinnon S, et al: Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation: Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation. Blood. 100:4310–4316. 2002.

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Copy and paste a formatted citation
Spandidos Publications style
Schmitt M, Trenschel R, Sayer HG, Schneider C, Glass A, Hilgendorf I, Treschl A, Junghanss C, Borchert K, Koenigsmann M, Koenigsmann M, et al: Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma. Mol Clin Oncol 2: 773-782, 2014.
APA
Schmitt, M., Trenschel, R., Sayer, H.G., Schneider, C., Glass, A., Hilgendorf, I. ... Kahl, C. (2014). Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma. Molecular and Clinical Oncology, 2, 773-782. https://doi.org/10.3892/mco.2014.300
MLA
Schmitt, M., Trenschel, R., Sayer, H. G., Schneider, C., Glass, A., Hilgendorf, I., Treschl, A., Junghanss, C., Borchert, K., Koenigsmann, M., Casper, J., Beelen, D. W., Freund, M., Kahl, C."Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma". Molecular and Clinical Oncology 2.5 (2014): 773-782.
Chicago
Schmitt, M., Trenschel, R., Sayer, H. G., Schneider, C., Glass, A., Hilgendorf, I., Treschl, A., Junghanss, C., Borchert, K., Koenigsmann, M., Casper, J., Beelen, D. W., Freund, M., Kahl, C."Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma". Molecular and Clinical Oncology 2, no. 5 (2014): 773-782. https://doi.org/10.3892/mco.2014.300
Copy and paste a formatted citation
x
Spandidos Publications style
Schmitt M, Trenschel R, Sayer HG, Schneider C, Glass A, Hilgendorf I, Treschl A, Junghanss C, Borchert K, Koenigsmann M, Koenigsmann M, et al: Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma. Mol Clin Oncol 2: 773-782, 2014.
APA
Schmitt, M., Trenschel, R., Sayer, H.G., Schneider, C., Glass, A., Hilgendorf, I. ... Kahl, C. (2014). Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma. Molecular and Clinical Oncology, 2, 773-782. https://doi.org/10.3892/mco.2014.300
MLA
Schmitt, M., Trenschel, R., Sayer, H. G., Schneider, C., Glass, A., Hilgendorf, I., Treschl, A., Junghanss, C., Borchert, K., Koenigsmann, M., Casper, J., Beelen, D. W., Freund, M., Kahl, C."Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma". Molecular and Clinical Oncology 2.5 (2014): 773-782.
Chicago
Schmitt, M., Trenschel, R., Sayer, H. G., Schneider, C., Glass, A., Hilgendorf, I., Treschl, A., Junghanss, C., Borchert, K., Koenigsmann, M., Casper, J., Beelen, D. W., Freund, M., Kahl, C."Conditioning with treosulfan and fludarabine for patients with refractory or relapsed non‑Hodgkin lymphoma". Molecular and Clinical Oncology 2, no. 5 (2014): 773-782. https://doi.org/10.3892/mco.2014.300
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