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Molecular and Clinical Oncology
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Article

Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer

  • Authors:
    • Chao-Hui Zuo
    • Hailong Xie
    • Jingshi Liu
    • Xiao-Xin Qiu
    • Jin-Guan Lin
    • Xiao Hua
    • Ang Qin
  • View Affiliations / Copyright

    Affiliations: Department of Gastroduodenal and Pancreatic Surgery, Hunan Provincial Tumor Hospital and Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 821-826
    |
    Published online on: June 3, 2014
       https://doi.org/10.3892/mco.2014.303
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Abstract

This study aimed to characterize lymph node metastasis and determine its clinical significance in the surgical treatment of gastric cancer. The medical charts of 920 gastric cancer patients who underwent radical surgical resection between March, 2010 and March, 2013, were retrospectively reviewed and statistically analyzed. Lymphatic metastasis was observed in 69.6% of the patients (640/920). The frequency of lymph node metastasis in patients with early‑stage gastric cancer was 21.4% (18/84). Lymph node metastasis was observed in all the patients with stage IIIC‑IV gastric cancer. The incidence of lymph node metastasis was higher among patients with tumors >7 cm in size. The most frequently affected lymph nodes in patients with proximal, central and distal gastric cancer were station no. 1 (34.2%), no. 3 (33.8%) and no. 6 (34.3%) lymph nodes, respectively. The frequency of lymph node metastasis in patients with Borrmann type IV cancer was significantly higher compared to that in patients with other Borrmann type cancers. Our study further demonstrated that lymphatic metastasis is closely correlated with TNM stage, location, depth of invasion and size of gastric tumors. Therefore, we recommend that a sufficient number of lymph nodes be examined from each patient to determine the extent of lymph node dissection based on Borrmann type, location, size, depth of invasion and histology of the cancer.
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1 

Peng J and Wang Y: Epidemiology, pathology and clinical management of multiple gastric cancers: a mini-review. Surg Oncol. 19:e110–e114. 2010. View Article : Google Scholar

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

3 

Wu Y, Fan Y, Jiang Y, Wang Y, Liu H and Wei M: Analysis of risk factors associated with precancerous lesion of gastric cancer in patients from eastern China: a comparative study. J Cancer Res Ther. 9:205–209. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Bedikian AY, Chen TT, Khankhanian N, et al: The natural history of gastric cancer and prognostic factors influencing survival. J Clin Oncol. 2:305–310. 1984.PubMed/NCBI

5 

Saka M, Katai H, Fukagawa T, Nijjar R and Sano T: Recurrence in early gastric cancer with lymph node metastasis. Gastric Cancer. 11:214–218. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Kunisaki C, Akiyama H, Nomura M, et al: Surgical outcomes for early gastric cancer in the upper third of the stomach. J Am Coll Surg. 200:15–19. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Ikeda Y, Saku M, Kishihara F and Maehara Y: Effective follow-up for recurrence or a second primary cancer in patients with early gastric cancer. Br J Surg. 92:235–239. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Takagane A, Terashima M, Abe K, et al: Evaluation of the ratio of lymph node metastasis as a prognostic factor in patients with gastric cancer. Gastric Cancer. 2:122–128. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Bando E, Yonemura Y, Taniguchi K, Fushida S, Fujimura T and Miwa K: Outcome of ratio of lymph node metastasis in gastric carcinoma. Ann Surg Oncol. 9:775–784. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Seevaratnam R, Bocicariu A, Cardoso R, et al: How many lymph nodes should be assessed in patients with gastric cancer? A systematic review. Gastric Cancer. 15(Suppl 1): S70–S88. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Xu J, Bian YH, Jin X and Cao H: Prognostic assessment of different metastatic lymph node staging methods for gastric cancer after D2 resection. World J Gastroenterol. 19:1975–1983. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Adachi Y: Definition of early gastric cancer and Dukes’s A tumor. J Am Coll Surg. 186:605–606. 1998.

13 

Saragoni L, Morgagni P, Gardini A, et al: Early gastric cancer: diagnosis, staging, and clinical impact. Evaluation of 530 patients. New elements for an updated definition and classification. Gastric Cancer. 16:549–554. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Tsuburaya A, Hayashi T and Yoshikawa T: Points of revision in the new Japanese treatment guidelines for gastric cancer. Nihon Rinsho. 70:1758–1762. 2012.(In Japaneese).

15 

Sobin LH, Gospodarowicz M and Wittekind C: TNM Classification of Malignant Tumors. Wiley-Blackwell; Oxford: 2009

16 

Lee SR, Kim HO, Son BH, Shin JH and Yoo CH: Prognostic significance of the metastatic lymph node ratio in patients with gastric cancer. World J Surg. 36:1096–1101. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Wang X, Appleby DH, Zhang X, Gan L, Wang JJ and Wan F: Comparison of three lymph node staging schemes for predicting outcome in patients with gastric cancer. Br J Surg. 100:505–514. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Wang HM, Huang CM, Zheng CH, et al: Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach. World J Gastroenterol. 18:5470–5475. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Tokunaga M, Ohyama S, Hiki N, et al: Investigation of the lymphatic stream of the stomach in gastric cancer with solitary lymph node metastasis. World J Surg. 33:1235–1239. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Han KB, Jang YJ, Kim JH, et al: Clinical significance of the pattern of lymph node metastasis depending on the location of gastric cancer. J Gastric Cancer. 11:86–93. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Blum MA, Takashi T, Suzuki A and Ajani JA: Management of localized gastric cancer. J Surg Oncol. 107:265–270. 2013. View Article : Google Scholar

22 

Okines A, Bang YJ and Cunningham D: Accomplishments in 2008 in the management of localized gastric cancer. Gastrointest Cancer Res. 3:S48–S52. 2009.PubMed/NCBI

23 

Kasakura Y, Mochizuki F, Wakabayashi K, Kochi M, Fujii M and Takayama T: An evaluation of the effectiveness of extended lymph node dissection in patients with gastric cancer: a retrospective study of 1403 cases at a single institution. J Surg Res. 103:252–259. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Li C, Oh SJ, Kim S, et al: Macroscopic Borrmann type as a simple prognostic indicator in patients with advanced gastric cancer. Oncology. 77:197–204. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Wu LL, Liang H, Wang XN, Liu XY and Han T: Clinical characteristics of 103 lymph node metastasis in advanced proximal gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi. 13:590–593. 2010.(In Chinese).

26 

Wang JB, Huang CM, Lu HS, et al: Efficacy of combined splenectomy in proximal gastric cancer with No. 10 lymph node metastasis. Chin J Gastrointest Surg. 12:121–125. 2009.(In Chinese).

27 

Shin SH, Jung H, Choi SH, et al: Clinical significance of splenic hilar lymph node metastasis in proximal gastric cancer. Ann Surg Oncol. 16:1304–1309. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Maruyama K, Sasako M, Kinoshita T, Sano T, Katai H and Okajima K: Pancreas-preserving total gastrectomy for proximal gastric cancer. World J Surg. 19:532–536. 1995. View Article : Google Scholar : PubMed/NCBI

29 

Hyung WJ, Lim JS, Song J, Choi SH and Noh SH: Laparoscopic spleen-preserving splenic hilar lymph node dissection during total gastrectomy for gastric cancer. J Am Coll Surg. 207:e6–e11. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Cesta MF: Normal structure, function, and histology of the spleen. Toxicol Pathol. 34:455–465. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Mönig SP, Collet PH, Baldus SE, et al: Splenectomy in proximal gastric cancer: frequency of lymph node metastasis to the splenic hilus. J Surg Oncol. 76:89–92. 2001.

32 

Li C, Kim S, Lai JF, et al: Solitary lymph node metastasis in gastric cancer. J Gastrointest Surg. 12:550–554. 2008. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zuo C, Xie H, Liu J, Qiu X, Lin J, Hua X and Qin A: Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer. Mol Clin Oncol 2: 821-826, 2014.
APA
Zuo, C., Xie, H., Liu, J., Qiu, X., Lin, J., Hua, X., & Qin, A. (2014). Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer. Molecular and Clinical Oncology, 2, 821-826. https://doi.org/10.3892/mco.2014.303
MLA
Zuo, C., Xie, H., Liu, J., Qiu, X., Lin, J., Hua, X., Qin, A."Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer". Molecular and Clinical Oncology 2.5 (2014): 821-826.
Chicago
Zuo, C., Xie, H., Liu, J., Qiu, X., Lin, J., Hua, X., Qin, A."Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer". Molecular and Clinical Oncology 2, no. 5 (2014): 821-826. https://doi.org/10.3892/mco.2014.303
Copy and paste a formatted citation
x
Spandidos Publications style
Zuo C, Xie H, Liu J, Qiu X, Lin J, Hua X and Qin A: Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer. Mol Clin Oncol 2: 821-826, 2014.
APA
Zuo, C., Xie, H., Liu, J., Qiu, X., Lin, J., Hua, X., & Qin, A. (2014). Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer. Molecular and Clinical Oncology, 2, 821-826. https://doi.org/10.3892/mco.2014.303
MLA
Zuo, C., Xie, H., Liu, J., Qiu, X., Lin, J., Hua, X., Qin, A."Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer". Molecular and Clinical Oncology 2.5 (2014): 821-826.
Chicago
Zuo, C., Xie, H., Liu, J., Qiu, X., Lin, J., Hua, X., Qin, A."Characterization of lymph node metastasis and its clinical significance in the surgical treatment of gastric cancer". Molecular and Clinical Oncology 2, no. 5 (2014): 821-826. https://doi.org/10.3892/mco.2014.303
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