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Article

Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study

  • Authors:
    • Nan Bao Zhong
    • Guang Ming Lv
    • Zhong Hua Chen
  • View Affiliations / Copyright

    Affiliations: Tumor Radiotherapy Center, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. China
  • Pages: 839-844
    |
    Published online on: June 6, 2014
       https://doi.org/10.3892/mco.2014.304
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Abstract

This study was conducted to evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) combined with transarterial chemoembolization (TACE) for huge (≥10 cm) hepatocellular carcinomas (HCCs). Between May, 2006 and December, 2012, 72 patients with huge HCCs were treated by SBRT following incomplete TACE. The median total dose of 35.6 Gy was delivered over 12-14 days with a fractional dose of 2.6-3.0 Gy and 6 fractions per week. The patients were classified into those with tumor encapsulation (group A, n=33) and those without tumor encapsulation (group B, n=39). The clinical outcomes of tumor response, overall cumulative survival and toxicities/complications were retrospectively analyzed. Among the 72 patients, CR, PR, SD and PD were achieved in 6 (8.3%), 51 (70.8%), 9 (12.5%) and 6 patients (8.3%), respectively, within a median follow‑up of 18 months. The objective response rate was 79.1%. The overall cumulative 1-, 3- and 5-year survival rates and the median survival time were 38, 12 and 3% and 12.2 months, respectively. In group A, the overall cumulative 1-, 3- and 5-year survival rates were 56, 21 and 6%, respectively, with a median survival of 19 months; in group B, the overall cumulative 1-, 3- and 5-year survival rates were 23, 4 and 0%, respectively, with a median survival of 10.8 months (P=0.023). The treatment was well tolerated, with no severe radiation‑induced liver disease and no reported > grade 3 toxicity. Tumor encapsulation was found to be a significant prognostic factor for survival. In conclusion, the combination of SBRT and TACE was shown to be a safe and effective treatment option for patients with unresectable huge HCC.
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1 

Sangiovanni A, Del Ninno E, Fasani P, et al: Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology. 126:1005–1014. 2004. View Article : Google Scholar

2 

Cormier JN, Thomas KT, Chari RS, et al: Management of hepatocellular carcinoma. J Gastrointest Surg. 10:761–780. 2006. View Article : Google Scholar

3 

Pakin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar

4 

Llovert JM, Burroughs A and Bruix J: Hepatocellular carcinoma. Lancet. 362:1907–1917. 2003. View Article : Google Scholar

5 

No authors listed. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. The Liver Cancer Group of Japan. Cancer. 74:2772–2780. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Bruix J and Sherman M; Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology. 42:1208–1236. 2005. View Article : Google Scholar

7 

Chirica M, Scatton O, Massault PP, et al: Treatment of stage IVA hepatocellular carcinoma: should we reappraise the role of surgery? Arch Surg. 143:538–543. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Mazzaferro V, Regalia E, Doci R, et al: Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 334:693–699. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Yanaga K: Current status of hepatic resection for hepatocellular carcinoma. J Gastroenterol. 39:919–926. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Zhou ZD, Tang ZY, Yang BH, et al: Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma. Cancer. 91:1479–1486. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Mazzaferro V, Chun YS, Poon RT, et al: Liver transplantation for hepatocellular carcinoma. Ann Surg Oncol. 15:1001–1007. 2008. View Article : Google Scholar

12 

Trevisani F, De Notariis S, Rossi C and Bernardi M: Randomized control trials on chemoembolization for hepatocellular carcinoma: Is there room for new studies? J Clin Gastroenterol. 32:383–389. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Hawkins MA and Dawson LA: Radiation therapy for hepatocellular carcinoma: from palliation to cure. Cancer. 106:1653–1663. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Meng MB, Cui YL, Lu Y, et al: Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: a systematic review and meta-analysis. Radiother Oncol. 92:184–194. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Ren ZG, Zhao JD, Gu K, et al: Three-dimensional conformal radiation therapy and intensity-modulated radiation therapy combined with transcatheter arterial chemoembolization for locally advanced hepatocellular carcinoma: an irradiation dose escalation study. Int J Radiat Oncol Biol Phys. 79:496–502. 2011. View Article : Google Scholar

16 

Law AL, Ng WT, Lee MC, et al: Treatment of primary liver cancer using highly-conformal radiotherapy with kV-image guidance and respiratory control. Radiother Oncol. 102:56–61. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yang ZX, Wang D, Wang G, et al: Clinical study of recombinant adenovirus-p53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinoma. J Cancer Res Clin Oncol. 136:625–630. 2010. View Article : Google Scholar

18 

Price TR, Perkins SM, Sandrasegaran K, et al: Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinoma. Cancer. 118:3191–3198. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Son SH, Choi BO, Ryu MR, et al: Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication. Int J Radiat Oncol Biol Phys. 78:1073–1080. 2010.PubMed/NCBI

20 

Zhong NB, Chen ZH and LV GM: A clinical study on stereotactic body radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis. J Cancer Res Ther. 1:143–148. 2013. View Article : Google Scholar

21 

WHO Handbook for Reporting Results of Cancer Treatment. WHO Offset Publication No. 48. World Health Organization; Geneva: 1979

22 

Shah SA, Greig PD, Galllinger S, et al: Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes. J Am Coll Surg. 202:275–283. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Regimbeau JM, Abdalla Ek, Vauthey JN, et al: Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study. J Surg Oncol. 85:36–41. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Yeh CN, Lee WC and Chen MF: Hepatic resection and prognosis for patients with hepatocellular carcinoma larger than 10 cm: two decades of experience at Chang Gung memorial hospital. Ann Surg Oncol. 10:1070–1076. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Shah SA, Wei AC, Cleary SP, et al: Prognosis and results after resection of very large (>or=10 cm) hepatocellular carcinoma. J Gastrointest Surg. 11:589–595. 2007. View Article : Google Scholar

26 

Pawlik TM, Delman KA, Vauthey JN, et al: Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl. 11:1086–1092. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Llovet JM, Schwartz M and Mazzaferro V: Resection and liver transplantation for hepatocellular carcinoma. Semin Liver Dis. 25:181–200. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Harada T, Matsuo K, Inoue T, et al: Is preoperative hepatic arterial chemoembolization safe and effective for hepatocellular carcinoma? Ann Surg. 224:4–9. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Lee JK, Chung YH, Song BC, et al: Recurrence of hepatocellular carcinoma following initial remission by transcatheter arterial chemoembolization. J Gastroenterol Hepatol. 17:52–58. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Mok KT, Wang BW, Lo GH, et al: Multimodality management of hepatocellular carcinoma larger than 10 cm. J Am Coll Surg. 197:730–738. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Wu TH, Yu MC, Chen TC, et al: Encapsulation is a significant prognostic factor for better outcome in large hepatocellular carcinoma. J Surg Oncol. 105:85–90. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Ng KM, Yan TD, Black D, et al: Prognostic determinants for survival after resection/ablation of a large hepatocellular carcinoma. HPB (Oxford). 11:311–320. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Chen XP, Qiu FZ, Wu ZD, et al: Long-term outcome of resection of large hepatocellular carcinoma. Br J Surg. 93:600–606. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Poon RT, Fan ST and Wong J: Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter. J Am Coll Surg. 194:592–602. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Lee MT, Kim JJ, Dinniwell R, et al: Phase I study of individualized stereotactic body radiotherapy of liver metastases. J Clin Oncol. 27:1585–1591. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Toya R, Murakami R, Baba Y, et al: Conformal radiotherapy for portal vein tumor thrombosis of hepatocellular carcinoma. Radiother Oncol. 84:266–271. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhong NB, Lv GM and Chen ZH: Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study. Mol Clin Oncol 2: 839-844, 2014.
APA
Zhong, N.B., Lv , G.M., & Chen, Z.H. (2014). Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study. Molecular and Clinical Oncology, 2, 839-844. https://doi.org/10.3892/mco.2014.304
MLA
Zhong, N. B., Lv , G. M., Chen, Z. H."Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study". Molecular and Clinical Oncology 2.5 (2014): 839-844.
Chicago
Zhong, N. B., Lv , G. M., Chen, Z. H."Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study". Molecular and Clinical Oncology 2, no. 5 (2014): 839-844. https://doi.org/10.3892/mco.2014.304
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong NB, Lv GM and Chen ZH: Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study. Mol Clin Oncol 2: 839-844, 2014.
APA
Zhong, N.B., Lv , G.M., & Chen, Z.H. (2014). Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study. Molecular and Clinical Oncology, 2, 839-844. https://doi.org/10.3892/mco.2014.304
MLA
Zhong, N. B., Lv , G. M., Chen, Z. H."Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study". Molecular and Clinical Oncology 2.5 (2014): 839-844.
Chicago
Zhong, N. B., Lv , G. M., Chen, Z. H."Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (≥10 cm) hepatocellular carcinomas: A clinical study". Molecular and Clinical Oncology 2, no. 5 (2014): 839-844. https://doi.org/10.3892/mco.2014.304
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