Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-October 2014 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2014 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review)

  • Authors:
    • Michael D. Weintraub
    • Qingdi Quentin Li
    • Piyush K. Agarwal
  • View Affiliations / Copyright

    Affiliations: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
  • Pages: 656-660
    |
    Published online on: June 12, 2014
       https://doi.org/10.3892/mco.2014.314
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The knowledge of tumor biology and the biomechanical properties of the urothelium have led to significant advances in the development of intravesical therapy for the treatment of non‑muscle invasive bladder cancer (NMIBC). Targeted therapy improves the efficacy and decreases the side effects of antineoplastic agents. Nanoparticles that target antitumor agents to the urothelial cells have allowed for improved delivery of these agents to tumor cells. Gene therapy is another strategy that has allowed for a targeted induction of an antitumor response. Finally, engineering of the bacillus Calmette‑Guérin (BCG) vaccine aimed to minimize the potential side effects associated with this treatment. These novel approaches hold promise for decreasing the rate of progression and recurrence of NMIBC.
View Figures
View References

1 

Botteman MF, Pashos CL, Redaelli A, Laskin B and Hauser R: The health economics of bladder cancer: a comprehensive review of the published literature. Pharmacoeconomics. 21:1315–1330. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Millan-Rodriguez F, Chechile-Toniolo G, Salvador-Bayarri J, Palou J and Vicente-Rodriguez J: Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol. 163:73–78. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Donat SM: Evaluation and follow-up strategies for superficial bladder cancer. Urol Clin North Am. 30:765–776. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Witjes JA and Hendricksen K: Intravesical pharmacotherapy for non-muscle-invasive bladder cancer: a critical analysis of currently available drugs, treatment schedules, and long-term results. Eur Urol. 53:45–52. 2008. View Article : Google Scholar

5 

Schwaibold HE, Sivalingam S, May F and Hartung R: The value of a second transurethral resection for T1 bladder cancer. BJU Int. 97:1199–1201. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Cookson MS and Sarosdy MF: Management of stage T1 superficial bladder cancer with intravesical bacillus Calmette-Guerin therapy. J Urol. 148:797–801. 1992.PubMed/NCBI

7 

Lamm DL, Blumenstein BA, Crissman JD, et al: Maintenance bacillus Calmette-Guerin immunotherapy for recurrent TA, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. J Urol. 163:1124–1129. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Lamm DL: Efficacy and safety of bacille Calmette-Guérin immunotherapy in superficial bladder cancer. Clin Infect Dis. 31(Suppl 3): S86–S90. 2000.

9 

GuhaSarkar S and Banerjee R: Intravesical drug delivery: challenges, current status, opportunities and novel strategies. J Control Release. 148:147–159. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Kang MR, Yang G, Place RF, et al: Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth. Cancer Res. 72:5069–5079. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Barlow L, McKiernan JM and Benson MC: Long-term survival outcomes with intravesical docetaxel for recurrent nonmuscle invasive bladder cancer after previous bacillus Calmette-Guérin therapy. J Urol. 189:834–839. 2013.

12 

Mugabe C, Matsui Y, So AI, et al: In vivo evaluation of mucoadhesive nanoparticulate docetaxel for intravesical treatment of non-muscle-invasive bladder cancer. Clin Cancer Res. 17:2788–2798. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Gradishar WJ, Tjulandin S, Davidson N, et al: Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol. 23:7794–7803. 2005. View Article : Google Scholar : PubMed/NCBI

14 

McKiernan JM, Barlow LJ, Laudano MA, Mann MJ, Petrylak DP and Benson MC: A phase I trial of intravesical nanoparticle albumin-bound paclitaxel in the treatment of bacillus Calmette-Guérin refractory nonmuscle invasive bladder cancer. J Urol. 186:448–451. 2011.PubMed/NCBI

15 

Buscarini M, Quek ML, Gilliam-Hegarich S, Kasahara N and Bochner B: Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder. Urol Int. 78:160–166. 2007. View Article : Google Scholar : PubMed/NCBI

16 

O’Donnell MA, Lilli K, Leopold C, et al: Interim results from a national multicenter phase II trial of combination bacillus Calmette-Guerin plus interferon alfa-2b for superficial bladder cancer. J Urol. 172:888–893. 2004.

17 

Yamashita M, Rosser CJ, Zhou JH, et al: Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer. Cancer Gene Ther. 9:687–691. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Dinney CP, Fisher MB, Navai N, et al: Phase I trial of intravesical recombinant adenovirus mediated interferon-α2b formulated in Syn3 for Bacillus Calmette-Guérin failures in nonmuscle invasive bladder cancer. J Urol. 190:850–856. 2013.PubMed/NCBI

19 

Ramesh N, Ge Y, Ennist DL, Zhu M, Mina M, Ganesh S, Reddy PS and Yu DC: CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor - armed oncolytic adenovirus for the treatment of bladder cancer. Clin Cancer Res. 12:305–313. 2006. View Article : Google Scholar

20 

Burke JM, Lamm DL, Meng MV, et al: A first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancer. J Urol. 188:2391–2397. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Seager CM, Puzio-Kuter AM, Patel T, et al: Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer. Cancer Prev Res (Phila). 2:1008–1014. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, et al: Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 23:675–680. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Zhang X and Godbey WT: Preclinical evaluation of a gene therapy treatment for transitional cell carcinoma. Cancer Gene Ther. 18:34–41. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Mohammed SI, Knapp DW, Bostwick DG, et al: Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Cancer Res. 59:5647–5650. 1999.PubMed/NCBI

25 

Morales A, Chin JL and Ramsey EW: Mycobacterial cell wall extract for treatment of carcinoma in situ of the bladder. J Urol. 166:1633–1638. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Filion MC and Phillips NC: Therapeutic potential of mycobacterial cell wall-DNA complexes. Expert Opin Investig Drugs. 10:2157–2165. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Morales A, Phadke K and Steinhoff G: Intravesical mycobacterial cell wall-DNA complex in the treatment of carcinoma in situ of the bladder after standard intravesical therapy has failed. J Urol. 181:1040–1045. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Ahn JJ and McKiernan JM: New agents for bacillus Calmette-Guérin-refractory bladder cancer. Urol Clin North Am. 40:219–232. 2013.PubMed/NCBI

29 

Miyazaki J, Kawai K, Kojima T, et al: The liposome-incorporating cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin can directly enhance the susceptibility of cancer cells to lymphokine-activated killer cells through up-regulation of natural-killer group 2, member D ligands. BJU Int. 108:1520–1526. 2011.PubMed/NCBI

30 

Miyazaki J, Nishiyama H, Yano I, et al: The therapeutic effects of R8-liposome-BCG-CWS on BBN-induced rat urinary bladder carcinoma. Anticancer Res. 31:2065–2071. 2011.PubMed/NCBI

31 

Andrade PM, Chade DC, Borra RC, et al: The therapeutic potential of recombinant BCG expressing the antigen S1PT in the intravesical treatment of bladder cancer. Urol Oncol. 28:520–525. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Weintraub MD, Li QQ and Agarwal PK: Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review). Mol Clin Oncol 2: 656-660, 2014.
APA
Weintraub, M.D., Li, Q.Q., & Agarwal, P.K. (2014). Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review). Molecular and Clinical Oncology, 2, 656-660. https://doi.org/10.3892/mco.2014.314
MLA
Weintraub, M. D., Li, Q. Q., Agarwal, P. K."Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review)". Molecular and Clinical Oncology 2.5 (2014): 656-660.
Chicago
Weintraub, M. D., Li, Q. Q., Agarwal, P. K."Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review)". Molecular and Clinical Oncology 2, no. 5 (2014): 656-660. https://doi.org/10.3892/mco.2014.314
Copy and paste a formatted citation
x
Spandidos Publications style
Weintraub MD, Li QQ and Agarwal PK: Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review). Mol Clin Oncol 2: 656-660, 2014.
APA
Weintraub, M.D., Li, Q.Q., & Agarwal, P.K. (2014). Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review). Molecular and Clinical Oncology, 2, 656-660. https://doi.org/10.3892/mco.2014.314
MLA
Weintraub, M. D., Li, Q. Q., Agarwal, P. K."Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review)". Molecular and Clinical Oncology 2.5 (2014): 656-660.
Chicago
Weintraub, M. D., Li, Q. Q., Agarwal, P. K."Advances in intravesical therapy for the treatment of non‑muscle invasive bladder cancer (Review)". Molecular and Clinical Oncology 2, no. 5 (2014): 656-660. https://doi.org/10.3892/mco.2014.314
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team