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Molecular and Clinical Oncology
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September-October 2014 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor

  • Authors:
    • Nan Yi
    • Ming Bing Xiao
    • Wen Kai Ni
    • Feng Jiang
    • Cui Hua Lu
    • Run‑Zhou Ni
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 767-772
    |
    Published online on: June 16, 2014
       https://doi.org/10.3892/mco.2014.317
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Abstract

Peroxiredoxin 4 (Prx4) has a number of important biological functions, such as efficient antioxidant capacity and promotion of cell proliferation and differentiation. The purpose of this study was to investigate the expression and significance of Prx4 in human colorectal cancer (CRC). Quantitative polymerase chain reaction (qPCR) was performed to detect Prx4 in 8 freshly frozen specimens of CRC and their adjacent normal tissues. In addition, immunohistochemical analysis was performed to detect Prx4 in 59 specimens of CRC and 26 of adjacent normal tissues. The immunohistochemical and qPCR results demonstrated that the expressions of the Prx4 gene and protein were higher in CRC compared to those in the adjacent normal tissues. The expression intensity of the Prx4 protein was correlated with depth of invasion (P=0.001), lymph node metastasis (P=0.006) and Dukes' classification (P=0.004) in CRC. The Kaplan‑Meier survival curves revealed that high Prx4 expression was correlated with short survival time. However, the Cox proportional hazards regression analysis did not identify Prx4 as an independent prognostic marker for CRC (P>0.05). These results suggested that Prx4 may be associated with carcinogenesis and the development of CRC and it may be a prognostic marker for postoperative CRC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Yi N, Xiao MB, Ni WK, Jiang F, Lu CH and Ni RZ: High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Mol Clin Oncol 2: 767-772, 2014.
APA
Yi, N., Xiao, M.B., Ni, W.K., Jiang, F., Lu, C.H., & Ni, R. (2014). High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Molecular and Clinical Oncology, 2, 767-772. https://doi.org/10.3892/mco.2014.317
MLA
Yi, N., Xiao, M. B., Ni, W. K., Jiang, F., Lu, C. H., Ni, R."High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor". Molecular and Clinical Oncology 2.5 (2014): 767-772.
Chicago
Yi, N., Xiao, M. B., Ni, W. K., Jiang, F., Lu, C. H., Ni, R."High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor". Molecular and Clinical Oncology 2, no. 5 (2014): 767-772. https://doi.org/10.3892/mco.2014.317
Copy and paste a formatted citation
x
Spandidos Publications style
Yi N, Xiao MB, Ni WK, Jiang F, Lu CH and Ni RZ: High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Mol Clin Oncol 2: 767-772, 2014.
APA
Yi, N., Xiao, M.B., Ni, W.K., Jiang, F., Lu, C.H., & Ni, R. (2014). High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Molecular and Clinical Oncology, 2, 767-772. https://doi.org/10.3892/mco.2014.317
MLA
Yi, N., Xiao, M. B., Ni, W. K., Jiang, F., Lu, C. H., Ni, R."High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor". Molecular and Clinical Oncology 2.5 (2014): 767-772.
Chicago
Yi, N., Xiao, M. B., Ni, W. K., Jiang, F., Lu, C. H., Ni, R."High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor". Molecular and Clinical Oncology 2, no. 5 (2014): 767-772. https://doi.org/10.3892/mco.2014.317
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