Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-October 2014 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2014 Volume 2 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study

  • Authors:
    • Vito Lorusso
    • Ignacio Duran
    • Cristina Garzon‑Rodriguez
    • Diana Lüftner
    • Amit Bahl
    • John Ashcroft
    • Guy Hechmati
    • Rachel Wei
    • Emma Thomas
    • Herbert Hoefeler
  • View Affiliations / Copyright

    Affiliations: Oncology Institute ASL, Lecce, Italy, Centro Integral Oncologica Clara Campal (CIOCC), Madrid, Spain, Catalan Institute of Oncology (ICO) ‑ Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, Berlin University of Medicine, Berlin, Germany, University Hospitals Bristol, Bristol, UK, Pinderfields General Hospital, Wakefield, UK, Health Economics, Amgen (Europe) GmbH, Zug, Switzerland, Department of Biostatistics, Amgen, Inc., Thousand Oaks, CA, USA, Scientific Publications, Amgen (Europe) GmbH, Zug, Switzerland, Research Center Ruhr, Witten, Germany
  • Pages: 701-708
    |
    Published online on: June 27, 2014
       https://doi.org/10.3892/mco.2014.330
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bone complications or skeletal‑related events (SREs), typically defined as radiation to bone, pathological fractures, surgery to bone and spinal cord compression, occur frequently in patients with bone metastases. As the survival of patients with advanced lung cancer improves, preventing SREs is becoming increasingly clinically relevant. The aim of this analysis was to assess the impact of SREs on health resource utilisation (HRU) in European lung cancer patients with bone metastasis. This multinational, observational study included patients who had at least one SRE in the 97 days prior to enrolment, a life expectancy of ≥6 months and an Eastern Cooperative Oncology Group performance status of 0‑2. Data on HRU were retrospectively collected for up to 97 days prior to enrolment with a planned prospective follow‑up for up to 18‑21 months. The HRU measures included the number and length of inpatient hospitalisations and the number of outpatient visits and procedures. The investigators determined whether each HRU was attributable to a SRE. In total, 135 patients with lung cancer, enrolled at centres in Germany, Italy, Spain and the United Kingdom, contributed 214 SREs to this analysis. The median length [quartile (Q)1, Q3] of follow‑up ranged from 1.5 (0.7, 3.3) to 5.6 (2.0, 8.2) months across the countries. Overall, 41% of the SREs required an inpatient stay, with a median (Q1, Q3) duration of 19.0 (6.0, 28.0) days. Spinal cord compression and surgery to bone were the SRE types most frequently requiring inpatient stays. Radiation to bone was associated with the largest number of outpatient visits and procedures. All the SREs resulting from bone metastases in patients with lung cancer contribute considerably to HRU and efforts to minimise the incidence of bone complications in these patients through appropriate treatments may help reduce this burden.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Steliarova-Foucher E, O’Callaghan M, Ferlay J, et al: European Cancer Observatory: Cancer Incidence, Mortality, Prevalence and Survival in Europe. Version 1.0. September. 2012, European Network of Cancer Registries, International Agency for Research on Cancer. http://eco.iarc.fr. Accessed June 18, 2013

2 

Coleman RE: Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 12:6243s–6249s. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Galasko C: The anatomy and pathways of skeletal metastases. Bone Metastases. Weiss L and Gilbert A: GK Hall; Boston: pp. 49–63. 1981

4 

Mok TS: Personalized medicine in lung cancer: what we need to know. Nat Rev Clin Oncol. 8:661–668. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Brodowicz T, O’Byrne K and Manegold C: Bone matters in lung cancer. Ann Oncol. 23:2215–2222. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Rosen LS, Gordon D, Tchekmedyian NS, et al: Long-term efficacy and safety of zoledronic acid in the treatment of skeletal metastases in patients with nonsmall cell lung carcinoma and other solid tumors: a randomized, phase III, double-blind, placebo-controlled trial. Cancer. 100:2613–2621. 2004. View Article : Google Scholar

7 

Costa L, Badia X, Chow E, Lipton A and Wardley A: Impact of skeletal complications on patients’ quality of life, mobility, and functional independence. Support Care Cancer. 16:879–889. 2008.

8 

Mercadante S: Malignant bone pain: pathophysiology and treatment. Pain. 69:1–18. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Loblaw DA, Wu JS, Kirkbride P, et al: Pain flare in patients with bone metastases after palliative radiotherapy - a nested randomized control trial. Support Care Cancer. 15:451–455. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Coleman RE: Skeletal complications of malignancy. Cancer. 80(Suppl 8): 1588–1594. 1997. View Article : Google Scholar

11 

National Collaborating Centre for Cancer (UK). Opioids in palliative care: safe and effective prescribing of strong opioids for pain in palliative care of adults. Full guideline. May;2012.PubMed/NCBI

12 

Loblaw DA, Perry J, Chambers A and Laperriere NJ: Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative’s Neuro-Oncology Disease Site Group. J Clin Oncol. 23:2028–2037. 2005.

13 

Katzer A, Meenen NM, Grabbe F and Rueger JM: Surgery of skeletal metastases. Arch Orthop Trauma Surg. 122:251–258. 2002. View Article : Google Scholar

14 

Body JJ, Chevalier P, Gunther O, Hechmati G and Lamotte M: The economic burden associated with skeletal-related events in patients with bone metastases secondary to solid tumors in Belgium. J Med Econ. 16:539–546. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Delea T, Langer C, McKiernan J, et al: The cost of treatment of skeletal-related events in patients with bone metastases from lung cancer. Oncology. 67:390–396. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Delea T, McKiernan J, Brandman J, et al: Retrospective study of the effect of skeletal complications on total medical care costs in patients with bone metastases of breast cancer seen in typical clinical practice. J Support Oncol. 4:341–347. 2006.PubMed/NCBI

17 

Pockett RD, Castellano D, McEwan P, Oglesby A, Barber BL and Chung K: The hospital burden of disease associated with bone metastases and skeletal-related events in patients with breast cancer, lung cancer, or prostate cancer in Spain. Eur J Cancer Care (Engl). 19:755–760. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Schulman KL and Kohles J: Economic burden of metastatic bone disease in the U.S. Cancer. 109:2334–2342. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Decroisette C, Monnet I, Berard H, et al: Epidemiology and treatment costs of bone metastases from lung cancer: a French prospective, observational, multicenter study (GFPC 0601). J Thorac Oncol. 6:576–582. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Hoefeler H, Duran I, Hechmati G, et al: Health resource utilization associated with skeletal-related events in patients with bone metastases: results from a multinational retrospective - prospective observational study - a cohort from 4 European countries. J Bone Oncol. (In press).

21 

Hechmati G, Cure S, Gouepo A, et al: Cost of skeletal-related events in European patients with solid tumours and bone metastases: data from a prospective multinational observational study. J Med Econ. 16:691–700. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Lüftner D, Lorusso V, Duran I, et al: Health resource utilization associated with skeletal-related events in patients with advanced breast cancer: results from a prospective, multinational observational study. Submitted for publication. 2013.

23 

Hoefeler H, Duran I, Hechmati G, et al: Health resource utilization (HRU) associated with skeletal-related events (SREs) by tumour type in patients with bone metastases/lesions: European analysis of a prospective multinational observational study. Eur J Cancer. 47:S262–S263. 2011.

24 

Lüftner D, Lorusso V, Duran I, et al: Health resource utilization (HRU) associated with skeletal-related events (SREs) in advanced breast cancer patients with bone metastases: results from a prospective multinational observational study. Cancer Res. 71(24 Suppl): abstract P4-16-09. 2011.

25 

Royal College of Radiologists. Single fraction radiotherapy for bone metastases. http://www.rcr.ac.uk/docs/oncology/pdf/bonemetsreport.pdf. Accessed June 27, 2013

26 

Williams MV, Summers ET, Drinkwater K and Barrett A: Radiotherapy dose fractionation, access and waiting times in the countries of the UK in 2005. Clin Oncol (R Coll Radiol). 19:273–286. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Casas A, Lebret T, Cavo M, et al: Insights into the management of bone metastases: a comprehensive European survey. Support Care Cancer. 20:S882012.

28 

Calderone R, Nimako K, Leary A, Popat S and O’Brien ME: Under usage of zoledronic acid in non-small cell lung cancer patients with metastatic bone disease - a short communication. Eur J Cancer. 47:1603–1605. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Woll PJ, Flinois A, Schoen P, Shepherd S and Haynes I: Insights into the management of bone metastases in patients with lung cancer: A comprehensive European survey. Eur J Cancer. 49:abstract 3473. 2013.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lorusso V, Duran I, Garzon‑Rodriguez C, Lüftner D, Bahl A, Ashcroft J, Hechmati G, Wei R, Thomas E, Hoefeler H, Hoefeler H, et al: Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study. Mol Clin Oncol 2: 701-708, 2014.
APA
Lorusso, V., Duran, I., Garzon‑Rodriguez, C., Lüftner, D., Bahl, A., Ashcroft, J. ... Hoefeler, H. (2014). Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study. Molecular and Clinical Oncology, 2, 701-708. https://doi.org/10.3892/mco.2014.330
MLA
Lorusso, V., Duran, I., Garzon‑Rodriguez, C., Lüftner, D., Bahl, A., Ashcroft, J., Hechmati, G., Wei, R., Thomas, E., Hoefeler, H."Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study". Molecular and Clinical Oncology 2.5 (2014): 701-708.
Chicago
Lorusso, V., Duran, I., Garzon‑Rodriguez, C., Lüftner, D., Bahl, A., Ashcroft, J., Hechmati, G., Wei, R., Thomas, E., Hoefeler, H."Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study". Molecular and Clinical Oncology 2, no. 5 (2014): 701-708. https://doi.org/10.3892/mco.2014.330
Copy and paste a formatted citation
x
Spandidos Publications style
Lorusso V, Duran I, Garzon‑Rodriguez C, Lüftner D, Bahl A, Ashcroft J, Hechmati G, Wei R, Thomas E, Hoefeler H, Hoefeler H, et al: Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study. Mol Clin Oncol 2: 701-708, 2014.
APA
Lorusso, V., Duran, I., Garzon‑Rodriguez, C., Lüftner, D., Bahl, A., Ashcroft, J. ... Hoefeler, H. (2014). Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study. Molecular and Clinical Oncology, 2, 701-708. https://doi.org/10.3892/mco.2014.330
MLA
Lorusso, V., Duran, I., Garzon‑Rodriguez, C., Lüftner, D., Bahl, A., Ashcroft, J., Hechmati, G., Wei, R., Thomas, E., Hoefeler, H."Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study". Molecular and Clinical Oncology 2.5 (2014): 701-708.
Chicago
Lorusso, V., Duran, I., Garzon‑Rodriguez, C., Lüftner, D., Bahl, A., Ashcroft, J., Hechmati, G., Wei, R., Thomas, E., Hoefeler, H."Health resource utilisation associated with skeletal‑related events in European patients with lung cancer: Α subgroup analysis from a prospective multinational study". Molecular and Clinical Oncology 2, no. 5 (2014): 701-708. https://doi.org/10.3892/mco.2014.330
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team