Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study

O'Connor,Juan  Manuel; Marmissolle,Fabiana; Bestani,Claudia; Pesce,Veronica; Belli,Susana; Dominichini,Enzo; Mendez,Guillermo; Price,Paola; Giacomi,Nora; Pairola,Alejandro; Loria,Fernando  Sánchez; Huertas,Eduardo; Martin,Claudio; Patane,Karina; Poleri,Claudia; Rosenberg,Moises; Cabanne,Ana; Kujaruk,Mirta; Caino,Analia; Zamora,Victor; Mariani,Javier; Dioca,Mariano; Parma,Patricia; Podesta,Gustavo; Andriani,Oscar; Gondolesi,Gabriel; Roca,Enrique

doi:10.3892/mco.2014.332

September-October 2014 Volume 2 Issue 5

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September-October 2014 Volume 2 Issue 5

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Article

Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study

Authors:
- Juan Manuel O'Connor
- Fabiana Marmissolle
- Claudia Bestani
- Veronica Pesce
- Susana Belli
- Enzo Dominichini
- Guillermo Mendez
- Paola Price
- Nora Giacomi
- Alejandro Pairola
- Fernando Sánchez Loria
- Eduardo Huertas
- Claudio Martin
- Karina Patane
- Claudia Poleri
- Moises Rosenberg
- Ana Cabanne
- Mirta Kujaruk
- Analia Caino
- Victor Zamora
- Javier Mariani
- Mariano Dioca
- Patricia Parma
- Gustavo Podesta
- Oscar Andriani
- Gabriel Gondolesi
- Enrique Roca
View Affiliations / Copyright

Affiliations: Department of Clinical Oncology, Institute Alexander Fleming, Buenos Aires C1426ANZ, Argentina, SITE, Clinical Oncology, La Plata 1900, Argentina, Oncology Unit, Gastroenterology Hospital Bonorino Udaondo, Buenos Aires C1264AAA, Argentina, Department of Clinical Oncology and Thoracic Surgery Unit, Respiratory Rehabilitation Hospital María Ferrer, Buenos Aires C1272AAA, Argentina, Department of Clinical Oncology, Institute A. Roffo, Buenos Aires C1417AAA, Argentina, Department of Hepatobiliary Pancreatic Disease, Austral University Hospital, Buenos Aires B1629AHJ, Argentina, Oncology and Hepatobiliary Pancreatic Units, Favaloro Foundation, Buenos Aires C1093AAS, Argentina
Pages: 673-684
|
Published online on: June 27, 2014

https://doi.org/10.3892/mco.2014.332
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Abstract

Neuroendocrine tumors (NET) include a spectrum of malignancies arising from neuroendocrine cells throughout the body. The objective of this clinical investigation of retrospectively and prospectively collected data was to describe the prevalence, demographic data, clinical symptoms and methods of diagnosis of NET and the treatment and long‑term follow‑up of patients with NET. Data were provided by the participating centers and assessed for consistency by internal reviewers. All the cases were centrally evaluated (when necessary) by the pathologists in our group. The tissue samples were reviewed by hematoxylin and eosin and immunohistochemical staining techniques to confirm the diagnosis of NET. In total, 532 cases were documented: 461 gastroenteropancreatic‑NET (GEP‑NET) and 71 bronchial NET (BNET). All the tumors were immunohistochemically defined according to the World Health Organization (WHO) and European Neuroendocrine Tumor Society criteria. The most common initial symptoms in GEP‑NET were abdominal pain, diarrhea, bowel obstruction, flushing, gastrointestinal bleeding and weight loss. The most common tumor types were carcinoid (58.0%), non‑functional pancreatic tumor (23.0%), metastatic NET of unknown primary (16.0%) and functional pancreatic tumor (3.0%). Of the BNET, 89.0% were typical and 11.0% atypical carcinoids. of the patients with GEP‑NET, 59.2% had distant metastasis at diagnosis. The locations of the primary tumors in GEP‑NET were the small bowel (26.9%), pancreas (25.2%), colon‑rectum (12.4%), appendix (7.6%), stomach (6.9%), esophagus (2.8%), duodenum (2.0%) and unknown primary (16.3%). The histological subtypes based on the WHO classification were well‑differentiated NET (20.1%), well‑differentiated neuroendocrine carcinomas (66.5%) and poorly differentiated neuroendocrine carcinomas (10.3%). Overall, 67.3% of the patients underwent surgery, 41.2% with curative intent and 26.1% for palliative purposes. The 5‑year survival rates were 65.1% (95% confidence interval, 58.0‑71.4%) in GEP‑NET and 100.0% in typical carcinoid of the lung. This observational, non‑interventional, longitudinal study aimed to accumulate relevant information regarding the epidemiology, clinical presentation and current practices in the treatment of NET patients in Argentina, providing insight into regional differences and patterns of care in this heterogeneous disease.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study

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