Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
January-February 2015 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-February 2015 Volume 3 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma

  • Authors:
    • Kang Liu
    • Jiaxin Ye
    • Yuan Huang
    • Chao Qin
    • Pu Li
    • Bianjiang Liu
    • Jie Li
    • Changjun Yin
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 93-100
    |
    Published online on: September 1, 2014
       https://doi.org/10.3892/mco.2014.406
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sulfotransferase isoform 1A1 (SULT1A1) is a member of the sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. A number of case‑control studies were conducted to investigate the association between the Arg213His polymorphism in SULT1A1 and the risk of urothelial carcinoma (UC) in humans. However, the results were inconsistent. A meta‑analysis based on 10 case‑control studies was performed to address this issue. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of this association. Between‑study heterogeneity was assessed with the Chi‑square‑based Q test. Overall, a possibly decreased risk of UC was associated with the SULT1A1 A/A polymorphism for the heterozygote model (OR=0.86, 95% CI: 0.76‑0.98, P=0.471). In the subgroup analysis by cancer type, the results indicated that individuals with the G/G genotype had a significantly higher bladder cancer (BC) risk (GA vs. GG: OR=0.88, 95% CI: 0.74‑0.99, P=0.626; GA/AA vs. GG: OR=0.85, 95% CI: 0.74‑0.97, P=0.504), which was contrary to the results of the upper urinary tract urothelial carcinoma (UTUC) group (AA vs. GG: OR=2.18, 95% CI: 1.28‑3.69; AA vs. GA/GG: OR=2.05, 95% CI: 1.24‑3.38). In addition, stratification by smoking status demonstrated that the Arg213His polymorphism was associated with a decreased risk of UC in non‑smokers (OR=0.70, 95% CI: 0.53‑0.92) but not in smokers (OR=0.85, 95% CI: 0.70‑1.03) under the dominant model. In conclusion, this meta‑analysis demonstrated a significant association between the SULT1A1 Arg213His polymorphism and BC. However, there was insufficient evidence to support a consistent association between this polymorphism and UC, partly due to the differences between BC and UTUC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chung CJ, Huang CY, Pu YS, Shiue HS, Su CT and Hsueh YM: The effect of cigarette smoke and arsenic exposure on urothelial carcinoma risk is modified by glutathione S-transferase M1 gene null genotype. Toxicol Appl Pharmacol. 266:254–259. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Milenkovic-Petronic D, Milojevic B, Djokic M, Sipetic-Grujicic S, Milojevic IG, Bumbasirevic U and Dzamic Z: The impact of tumor size on outcomes in patients with upper urinary tract urothelial carcinoma. Int Urol Nephrol. 46:563–569. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tanaka N, Kikuchi E, Kanao K, et al: The predictive value of positive urine cytology for outcomes following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma: a multi-institutional study. Urol Oncol. 32(48): e19–26. 2014. View Article : Google Scholar

4 

Peng Q, Mo C, Tang W, et al: DNA repair gene XRCC3 polymorphisms and bladder cancer risk: a meta-analysis. Tumour Biol. 35:1933–1944. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Ross JS, Wang K, Al-Rohil RN, et al: Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy. Mod Pathol. 27:271–280. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Glatt H and Meinl W: Pharmacogenetics of soluble sulfotransferases (SULTs). Naunyn Schmiedebergs Arch Pharmacol. 369:55–68. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Ginsberg G, Guyton K, Johns D, et al: Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment. Crit Rev Toxicol. 40:575–619. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Wang YH, Juang GD, Hwang TI, et al: Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population. Int J Urol. 15:1029–1034. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Dooley TP, Obermoeller RD, Leiter EH, et al: Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. Genomics. 18:440–443. 1993. View Article : Google Scholar : PubMed/NCBI

10 

Pereira WO, Paiva AS, Queiroz JW, et al: Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer. Cancer Genet Cytogenet. 160:55–60. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Daniels J and Kadlubar S: Sulfotransferase genetic variation: from cancer risk to treatment response. Drug Metab Rev. 45:415–422. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Chou HC, Lang NP and Kadlubar FF: Metabolic activation of the N-hydroxy derivative of the carcinogen 4-aminobiphenyl by human tissue sulfotransferases. Carcinogenesis. 16:413–417. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Davey Smith G and Egger M: Meta-analyses of randomised controlled trials. Lancet. 350(1182)1997.

14 

Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI

15 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

16 

Ozawa S, Katoh T, Inatomi H, et al: Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 102:418–421. 2002. View Article : Google Scholar

17 

Tsukino H, Kuroda Y, Nakao H, et al: Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer. J Cancer Res Clin Oncol. 130:99–106. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Rouprêt M, Cancel-Tassin G, Comperat E, et al: Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma. Cancer Epidemiol Biomarkers Prev. 16:2500–2503. 2007.

19 

Covolo L, Placidi D, Gelatti U, et al: Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study. Eur J Epidemiol. 23:355–362. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Kellen E, Zeegers M, Paulussen A, et al: Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. Cancer Lett. 245:51–60. 2007. View Article : Google Scholar

21 

Hung RJ, Boffetta P, Brennan P, et al: GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Int J Cancer. 110:598–604. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Cui X, Lu X, Hiura M, et al: Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population. Environ Health Prev Med. 18:136–142. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Zheng L, Wang Y, Schabath MB, Grossman HB and Wu X: Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. Cancer Lett. 202:61–69. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Yu X, Kubota T, Dhakal I, et al: Copy number variation in sulfotransferase isoform 1A1 (SULT1A1) is significantly associated with enzymatic activity in Japanese subjects. Pharmgenomics Pers Med. 6:19–24. 2013.PubMed/NCBI

25 

Tengström M, Mannermaa A, Kosma VM, Hirvonen A and Kataja V: SULT1A1 rs9282861 polymorphism - a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer? BMC Cancer. 12:2572012.PubMed/NCBI

26 

Coughtrie MW, Gilissen RA, Shek B, et al: Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations. Biochem J. 337:45–49. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Munafò MR and Flint J: Meta-analysis of genetic association studies. Trends Genet. 20:439–444. 2004.PubMed/NCBI

28 

Patel N, Arya M, Muneer A, et al: Molecular aspects of upper tract urothelial carcinoma. Urol Oncol. 32(28): e11–20. 2014. View Article : Google Scholar

29 

Catto JW, Azzouzi AR, Amira N, et al: Distinct patterns of microsatellite instability are seen in tumours of the urinary tract. Oncogene. 22:8699–8706. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Catto JW, Azzouzi AR, Rehman I, et al: Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma. J Clin Oncol. 23:2903–2910. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Roupret M, Catto J, Coulet F, et al: Microsatellite instability as indicator of MSH2 gene mutation in patients with upper urinary tract transitional cell carcinoma. J Med Genet. 41:e912004. View Article : Google Scholar : PubMed/NCBI

32 

Bermejo JL, Eng C and Hemminki K: Cancer characteristics in Swedish families fulfilling criteria for hereditary nonpolyposis colorectal cancer. Gastroenterology. 129:1889–1899. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Green DA, Rink M, Xylinas E, et al: Urothelial carcinoma of the bladder and the upper tract: disparate twins. J Urol. 189:1214–1221. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Liang FX, Bosland MC, Huang H, et al: Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement. J Cell Biol. 171:835–844. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Klug SJ, Ressing M, Koenig J, et al: TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncol. 10:772–784. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Tyler A: Urothelial cancers: ureter, renal pelvis, and bladder. Semin Oncol Nurs. 28:154–162. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Crivelli JJ, Xylinas E, Kluth LA, et al: Effect of smoking on outcomes of urothelial carcinoma: a systematic review of the literature. Eur Urol. 65:742–754. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu K, Ye J, Huang Y, Qin C, Li P, Liu B, Li J and Yin C: Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma. Mol Clin Oncol 3: 93-100, 2015.
APA
Liu, K., Ye, J., Huang, Y., Qin, C., Li, P., Liu, B. ... Yin, C. (2015). Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma. Molecular and Clinical Oncology, 3, 93-100. https://doi.org/10.3892/mco.2014.406
MLA
Liu, K., Ye, J., Huang, Y., Qin, C., Li, P., Liu, B., Li, J., Yin, C."Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma". Molecular and Clinical Oncology 3.1 (2015): 93-100.
Chicago
Liu, K., Ye, J., Huang, Y., Qin, C., Li, P., Liu, B., Li, J., Yin, C."Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma". Molecular and Clinical Oncology 3, no. 1 (2015): 93-100. https://doi.org/10.3892/mco.2014.406
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Ye J, Huang Y, Qin C, Li P, Liu B, Li J and Yin C: Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma. Mol Clin Oncol 3: 93-100, 2015.
APA
Liu, K., Ye, J., Huang, Y., Qin, C., Li, P., Liu, B. ... Yin, C. (2015). Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma. Molecular and Clinical Oncology, 3, 93-100. https://doi.org/10.3892/mco.2014.406
MLA
Liu, K., Ye, J., Huang, Y., Qin, C., Li, P., Liu, B., Li, J., Yin, C."Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma". Molecular and Clinical Oncology 3.1 (2015): 93-100.
Chicago
Liu, K., Ye, J., Huang, Y., Qin, C., Li, P., Liu, B., Li, J., Yin, C."Quantitative analysis of the association between sulfotransferase isoform 1A1 polymorphism and risk of urothelial carcinoma". Molecular and Clinical Oncology 3, no. 1 (2015): 93-100. https://doi.org/10.3892/mco.2014.406
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team