Establishment of the hybrid endoscopic full‑thickness resection of gastric gastrointestinal stromal tumors

Mori,Hirohito; Kobara,Hideki; Fujihara,Shintaro; Nishiyama,Noriko; Ayagi,Maki; Matsunaga,Tae; Yachida,Tatsuo; Masaki,Tsutomu

doi:10.3892/mco.2014.412

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article Open Access

Establishment of the hybrid endoscopic full‑thickness resection of gastric gastrointestinal stromal tumors

Authors:
- Hirohito Mori
- Hideki Kobara
- Shintaro Fujihara
- Noriko Nishiyama
- Maki Ayagi
- Tae Matsunaga
- Tatsuo Yachida
- Tsutomu Masaki
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Neurology, Kagawa University, Miki, Kita, Kagawa 761‑0793, Japan
Pages: 18-22
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Published online on: September 9, 2014

https://doi.org/10.3892/mco.2014.412
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Abstract

A prospective observational study was conducted to establish the procedure of hybrid endoscopic full‑thickness resection (EFTR) using an existing flexible endoscope. The present study included 16 patients who underwent hybrid EFTR between September 2009 and February 2013 for gastric gastrointestinal stromal tumor (GIST). The patients were selected using the following inclusion criteria for histological findings: Mitotic counts <5/high‑power field and immunohistochemical stains positive for KIT or cluster of differentiation 34 (CD34). The mean patient age was 68.2 years (range, 44‑81 years); the male‑to‑female ratio was 6:10; lesion sites at upper (U), middle (M) and lower regions (L) of the stomach were 9/6/1; and the average tumor diameter was 28.3 mm. The mean surgical time was 271 min and the surgical time became progressively faster with each successive surgery. There were 12 and four patients with mitotic counts of <5 and 5‑10, respectively, which was significantly different (P=0.01). Immunohistochemical stains showed that tumors from 13 and 10 patients (81.2 and 62.5%, respectively) were positive for KIT and CD34, respectively (P=0.328). All resected surgical margins were negative. According to Fletcher's risk classification, there were five, eight and three patients at an ‘extremely low’, ‘low’, and ‘intermediate’ risk (31.2, 50 and 18.8%, respectively) (P=0.003). The mean postoperative hospital duration was 12.3 days (range, 10‑15 days). In conclusion, an ultra‑minimally invasive surgery‑hybrid EFTR is a safe and established surgical endoscopy procedure.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Establishment of the hybrid endoscopic full‑thickness resection of gastric gastrointestinal stromal tumors

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Abstract

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