Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma

Hokka,Daisuke; Uchino,Kazuya; Tane,Kenta; Ogawa,Hiroyuki; Tane,Sinya; Tanaka,Yugo; Tauchi,Shunsuke; Nishio,Wataru; Yoshimura,Masahiro; Maniwa,Yoshimasa

doi:10.3892/mco.2014.416

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma

Authors:
- Daisuke Hokka
- Kazuya Uchino
- Kenta Tane
- Hiroyuki Ogawa
- Sinya Tane
- Yugo Tanaka
- Shunsuke Tauchi
- Wataru Nishio
- Masahiro Yoshimura
- Yoshimasa Maniwa
View Affiliations / Copyright

Affiliations: Division of Thoracic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan, Department of Thoracic Surgery, Hyogo Cancer Center, Akashi, Hyogo 673-8558, Japan
Pages: 244-248
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Published online on: September 10, 2014

https://doi.org/10.3892/mco.2014.416
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Abstract

We previously reported that cancer cells may be detected through pleural lavage cytology (PLC). In this study, we sought to re‑examine the prognostic significance of the PLC status based on an extended dataset with an additional follow-up period. Pleural lavage following thoracotomy was cytologically examined in 1,317 consecutive patients who were diagnosed with NSCLC between 1987 and 2004 at the Thoracic Surgery Units of Kobe University Graduate School of Medicine and Hyogo Cancer Center. Among the investigated patients, 46 exhibited positive cytological findings. The prognosis of these patients was significantly worse compared to that of patients without positive PLC. Of the 844 pathological stage I patients, 18 had a positive PLC status and their prognosis was significantly worse compared to that of patients with stage I disease without positive PLC. In conclusion, positive PLC findings were associated with a poor prognosis and this finding was significant for patients with stage I disease. These results suggest the need for PLC status evaluation during staging and treatment planning in patients with NSCLC.

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