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Article

Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis

  • Authors:
    • Yang‑Long Guo
    • Ying‑Li Zhang
    • Jian‑Qing Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 125-132
    |
    Published online on: September 18, 2014
       https://doi.org/10.3892/mco.2014.417
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Abstract

This study was conducted to determine the prognostic value of serum α‑fetoprotein (AFP) levels in patients with ovarian yolk sac tumor (OYST). We performed a systematic review and meta‑analysis to assess the associations between serum AFP level and prognosis in OYST. A total of 12 quantitative studies met the inclusion criteria. Preoperative AFP was not found to be associated with overall survival (OS) [odds ratio (OR)=0.84, 95% confidence interval (CI): 0.43‑1.62] in OYST. However, a high postoperative AFP level was associated with worse OS (OR=0.16, 95% CI: 0.05‑0.48) and relapse‑free survival (RFS) (OR=0.18, 95% CI: 0.08‑0.43) compared to a low postoperative AFP level in patients with OYST. In addition, a postoperative AFP level of >1,000 ng̸ml was associated with a decrease in OS (OR=0.16, 95% CI: 0.05‑0.50) and RFS (OR=0.21, 95% CI: 0.08‑0.57). In conclusion, the postoperative, but not the preoperative, AFP level was found to be a prognostic factor in patients with OYST. In particular, a postoperative AFP level of >1,000 ng/ml was an indicator of poor prognosis in patients with OYST.
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Copy and paste a formatted citation
Spandidos Publications style
Guo YL, Zhang YL and Zhu JQ: Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis. Mol Clin Oncol 3: 125-132, 2015.
APA
Guo, Y., Zhang, Y., & Zhu, J. (2015). Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 3, 125-132. https://doi.org/10.3892/mco.2014.417
MLA
Guo, Y., Zhang, Y., Zhu, J."Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis". Molecular and Clinical Oncology 3.1 (2015): 125-132.
Chicago
Guo, Y., Zhang, Y., Zhu, J."Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis". Molecular and Clinical Oncology 3, no. 1 (2015): 125-132. https://doi.org/10.3892/mco.2014.417
Copy and paste a formatted citation
x
Spandidos Publications style
Guo YL, Zhang YL and Zhu JQ: Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis. Mol Clin Oncol 3: 125-132, 2015.
APA
Guo, Y., Zhang, Y., & Zhu, J. (2015). Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 3, 125-132. https://doi.org/10.3892/mco.2014.417
MLA
Guo, Y., Zhang, Y., Zhu, J."Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis". Molecular and Clinical Oncology 3.1 (2015): 125-132.
Chicago
Guo, Y., Zhang, Y., Zhu, J."Prognostic value of serum α‑fetoprotein in ovarian yolk sac tumors: A systematic review and meta‑analysis". Molecular and Clinical Oncology 3, no. 1 (2015): 125-132. https://doi.org/10.3892/mco.2014.417
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