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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer

  • Authors:
    • Biao Geng
    • Man-Man Liang
    • Xiao-Bing Ye
    • Wen-Ying Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Internal Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China
  • Pages: 232-236
    |
    Published online on: September 18, 2014
       https://doi.org/10.3892/mco.2014.419
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Abstract

The objective of this study was to investigate the association of serum cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels with clinicopathological parameters in patients diagnosed with metastatic breast cancer (MBC). We retrospectively evaluated the medical records of 284 patients diagnosed with MBC between January, 2007 and December, 2012 who fulfilled the specified criteria and the association between the levels of the two tumor marker and clinicopathological parameters was analyzed. Of the 284 patients, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were identified in 163 (57.4%) and 97 (34.2%) patients, respectively. Elevated CA 15-3 and CEA levels were significantly associated with breast cancer molecular subtypes (P<0.001 and P=0.032, respectively). Cases with luminal subtypes exhibited a higher percentage of elevated CA 15-3 and CEA levels compared to non-luminal subtypes. Elevated CA 15-3 level was correlated with bone metastasis (P=0.017). However, elevation of CEA was observed regardless of the site of metastasis. Elevation of CA 15-3 was significantly more common in MBC with multiple metastatic sites compared to MBC with a single metastasis (P=0.001). However, the incidence of elevated CEA levels did not differ between patients with a single and those with multiple metastatic sites. In conclusion, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were found to be associated with breast cancer molecular subtypes, whereas an elevated CA 15-3 level was significantly correlated with bone metastasis and an elevated CEA level was observed regardless of metastatic site. The proportion of MBC cases with elevated CA 15-3 levels differed according to the number of metastatic sites.
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Copy and paste a formatted citation
Spandidos Publications style
Geng B, Liang M, Ye X and Zhao W: Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer. Mol Clin Oncol 3: 232-236, 2015.
APA
Geng, B., Liang, M., Ye, X., & Zhao, W. (2015). Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer. Molecular and Clinical Oncology, 3, 232-236. https://doi.org/10.3892/mco.2014.419
MLA
Geng, B., Liang, M., Ye, X., Zhao, W."Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer". Molecular and Clinical Oncology 3.1 (2015): 232-236.
Chicago
Geng, B., Liang, M., Ye, X., Zhao, W."Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer". Molecular and Clinical Oncology 3, no. 1 (2015): 232-236. https://doi.org/10.3892/mco.2014.419
Copy and paste a formatted citation
x
Spandidos Publications style
Geng B, Liang M, Ye X and Zhao W: Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer. Mol Clin Oncol 3: 232-236, 2015.
APA
Geng, B., Liang, M., Ye, X., & Zhao, W. (2015). Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer. Molecular and Clinical Oncology, 3, 232-236. https://doi.org/10.3892/mco.2014.419
MLA
Geng, B., Liang, M., Ye, X., Zhao, W."Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer". Molecular and Clinical Oncology 3.1 (2015): 232-236.
Chicago
Geng, B., Liang, M., Ye, X., Zhao, W."Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer". Molecular and Clinical Oncology 3, no. 1 (2015): 232-236. https://doi.org/10.3892/mco.2014.419
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