An assessment of selected immune parameters of patients with Hodgkin's disease

Kołtan,Andrzej; Kołtan,Sylwia; Dębski,Robert; Grześk,Elżbieta; Wysocki,Mariusz; Grześk,Grzegorz

doi:10.3892/mco.2014.421

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

An assessment of selected immune parameters of patients with Hodgkin's disease

Authors:
- Andrzej Kołtan
- Sylwia Kołtan
- Robert Dębski
- Elżbieta Grześk
- Mariusz Wysocki
- Grzegorz Grześk
View Affiliations / Copyright

Affiliations: Department of Pediatrics, Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz 85‑094, Poland, Department of Pediatrics, Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz 85‑094, Poland, Department of Pharmacology and Therapeutics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz 85‑094, Poland
Pages: 237-243
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Published online on: September 19, 2014

https://doi.org/10.3892/mco.2014.421
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Abstract

Malignancy and oncologic treatment lead to various secondary immune disorders. In particular, little is known regarding immune reconstitution following cancer therapy. Lymphocytes, their subpopulations and immunoglobulin serum concentrations were assessed in patients with Hodgkin's disease at diagnosis (group I, 26 patients), cessation of therapy (group II, 21 patients) and 2 years after treatment (group III, 18 patients). Absolute lymphocyte count was significantly decreased in group II only (15/21 vs. 6/26 and 0/18 patients). In group I, the absolute count of the following subsets were decreased: Cluster of differentiation 19+ (CD19+) (18/26 patients), CD3+ (13/26), CD3+CD4+ (11/26) and CD3+CD8+ (7/26). In group II, the reduction of CD19+, CD3+ and CD3+CD4+ cell counts was evident (12/21, 16/21 and 19/21 patients, respectively), with the CD3+CD4+/CD3+CD8+ ratio distinctly lowered in the majority of patients (16/21). Similar changes in the percentages of lymphocyte subsets were observed. In the majority of patients in group III, the percentage of lymphocyte subsets were normal, but absolute lymphocyte counts were elevated (CD19+ in 11/18, CD3+ in 12/18, CD3+CD4+ in 13/18 and CD3+CD8+ in 11/18 patients). In half the patients at diagnosis, immunoglobulin G (IgG) was significantly elevated. In conclusion, disorders assessed in the percentage distribution and individual subpopulations of lymphocytes was applicable mainly to patients at the time of the diagnosis and shortly following completion of treatment. The analysis of time‑distant consequences showed disorders only in the content of the percentage of CD4+ memory cells. The concentration of IgG at the time of diagnosis was significantly elevated in half the patients, which is possibly associated with the pathogenesis of the disease. The treatment does not appear to noticeably affect the production of IgG, IgA and IgM.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

An assessment of selected immune parameters of patients with Hodgkin's disease

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