Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle

Toyoshima,Naoya; Sakamoto,Taku; Makazu,Makomo; Nakajima,Takeshi; Matsuda,Takahisa; Kushima,Ryoji; Shimoda,Tadakazu; Fujii,Takahiro; Inoue,Haruhiro; Kudo,Shin‑Ei; Saito,Yutaka

doi:10.3892/mco.2014.423

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle

Authors:
- Naoya Toyoshima
- Taku Sakamoto
- Makomo Makazu
- Takeshi Nakajima
- Takahisa Matsuda
- Ryoji Kushima
- Tadakazu Shimoda
- Takahiro Fujii
- Haruhiro Inoue
- Shin‑Ei Kudo
- Yutaka Saito
View Affiliations / Copyright

Affiliations: Endoscopy Division, National Cancer Center Hospital, Tokyo 104‑0045, Japan, Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104‑0045, Japan, Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104‑0061, Japan, TF Clinic, Tokyo 104‑0061, Japan, Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224‑8503, Japan
Pages: 69-72
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Published online on: September 22, 2014

https://doi.org/10.3892/mco.2014.423
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Abstract

We assessed the clinicopathological characteristics of patients with serrated polyposis syndrome (SPS) and the incidence of advanced adenoma/colorectal cancer (CRC). We prospectively enrolled 249 consecutive patients who underwent colonoscopy at the National Cancer Center Hospital over a 6‑month period. All the polyps were diagnosed using magnification colonoscopy and resection/biopsy. The enrolled patients were divided into two groups, i) those with ≥5 histologically diagnosed hyperplastic polyps (HPs) proximal to the sigmoid colon, with at least 2 polyps >10 mm in diameter and ii) those with ≥20 HPs distributed throughout the colon. The clinical characteristics of the two groups were compared, including lifestyle, family history of CRC and colonoscopic findings. HPs were identified in 228 patients, of whom 21 (8.4%) had SPS. All 21 patients had ≥20 HPs distributed throughout the colon, with none having >2 HPs ≥1 cm in diameter in the right colon. Synchronous advanced adenoma/CRC was diagnosed in 76̸249 (30.5%) patients. The prevalence of advanced adenoma/CRC was higher among patients with compared to those without SPS (P=0.075). SPS was also associated with older age and higher body mass index (BMI). Our results suggested that older age and higher BMI are independent risk factors for SPS. Advanced adenoma/CRC tended to occur more frequently among patients with compared to those without SPS, although the difference was not statistically significant.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle

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