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Article

Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt

  • Authors:
    • Laila M. Sherief
    • Usama R. Elsafy
    • Elhamy R. Abdelkhalek
    • Naglaa M. Kamal
    • Doaa M. Youssef
    • Rabab Elbehedy
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Al Sharqiyah, Egypt, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
  • Pages: 139-144
    |
    Published online on: September 24, 2014
       https://doi.org/10.3892/mco.2014.425
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Abstract

Non‑Hodgkin lymphoma (NHL) accounts for 8‑10% of all childhood cancers. NHL collectively represents various lymphoid malignancies with diverse clinicopathological and biological characteristics. In this study, we aimed to describe the epidemiological and clinicopathological characteristics and treatment outcomes of pediatric NHL patients treated at the Pediatric Oncology Unit of Zagazig University Hospital and the Benha Specialized Pediatric Hospital. We conducted a cross‑sectional retrospective study by reviewing the medical records of 142 patients admitted with a diagnosis of NHL over a period of 8 years (February, 2004 to February, 2012) in these two Oncology Units. The age at presentation ranged between 2 and 15 years, with a mean ± standard deviation (SD) of 6.1±2.8 years and a male:female ratio of 1.7:1. Abdominal involvement was the most common presentation (73.2%). Burkitt's lymphoma (BL) was the most common NHL subtype (69%), followed by lymphoblastic lymphoma, diffuse large B‑cell lymphoma and anaplastic large‑cell lymphoma, accounting for 18.3, 10.6 and 2.1% of the cases, respectively. The majority of the patients (88.7%) had been diagnosed with advanced disease (Murphy stage III/IV). Complete remission was achieved in 120 cases (84.5%). A total of 16 patients (11.3%) succumbed to the disease during the first few months and 6 patients (4.2%) remained alive following relapse. The mean follow‑up duration ± SD was 34.6±25.1 months (range, 3‑84 months). the 5‑year overall survival (OS) and event‑free survival (EFS) rates were 88.7 and 85.1%, respectively. None of the clinical, epidemiological or pathological variables exhibited a statistically significant association with the OS or EFS. In conclusion, NHL occurs at a younger age, with a higher incidence of BL and advanced‑stage disease. The outcome of NHL in our two centers was satisfactory, approaching the international rates.
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Copy and paste a formatted citation
Spandidos Publications style
Sherief LM, Elsafy UR, Abdelkhalek ER, Kamal NM, Youssef DM and Elbehedy R: Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt. Mol Clin Oncol 3: 139-144, 2015.
APA
Sherief, L.M., Elsafy, U.R., Abdelkhalek, E.R., Kamal, N.M., Youssef, D.M., & Elbehedy, R. (2015). Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt. Molecular and Clinical Oncology, 3, 139-144. https://doi.org/10.3892/mco.2014.425
MLA
Sherief, L. M., Elsafy, U. R., Abdelkhalek, E. R., Kamal, N. M., Youssef, D. M., Elbehedy, R."Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt". Molecular and Clinical Oncology 3.1 (2015): 139-144.
Chicago
Sherief, L. M., Elsafy, U. R., Abdelkhalek, E. R., Kamal, N. M., Youssef, D. M., Elbehedy, R."Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt". Molecular and Clinical Oncology 3, no. 1 (2015): 139-144. https://doi.org/10.3892/mco.2014.425
Copy and paste a formatted citation
x
Spandidos Publications style
Sherief LM, Elsafy UR, Abdelkhalek ER, Kamal NM, Youssef DM and Elbehedy R: Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt. Mol Clin Oncol 3: 139-144, 2015.
APA
Sherief, L.M., Elsafy, U.R., Abdelkhalek, E.R., Kamal, N.M., Youssef, D.M., & Elbehedy, R. (2015). Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt. Molecular and Clinical Oncology, 3, 139-144. https://doi.org/10.3892/mco.2014.425
MLA
Sherief, L. M., Elsafy, U. R., Abdelkhalek, E. R., Kamal, N. M., Youssef, D. M., Elbehedy, R."Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt". Molecular and Clinical Oncology 3.1 (2015): 139-144.
Chicago
Sherief, L. M., Elsafy, U. R., Abdelkhalek, E. R., Kamal, N. M., Youssef, D. M., Elbehedy, R."Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt". Molecular and Clinical Oncology 3, no. 1 (2015): 139-144. https://doi.org/10.3892/mco.2014.425
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