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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma

  • Authors:
    • Samer Salah
    • Samar Toubasi
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, King Hussein Cancer Center, Al-Jubeiha 11941, Amman, Jordan, Department of Clinical Nursing, The University of Jordan, Al-Jubeiha 11942, Amman, Jordan
  • Pages: 157-162
    |
    Published online on: September 24, 2014
       https://doi.org/10.3892/mco.2014.426
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Abstract

Pulmonary metastasectomy (PM) is associated with improved survival of patients with metastatic osteosarcoma; however, the factors affecting survival following achievement of complete surgical remission remain controversial. The main objective of this study was to report the outcomes and prognostic factors of osteosarcoma patients who achieved complete remission (CR) following PM. We analyzed the effect of demographic and disease-related characteristics on the overall survival (OS) of consecutive patients with metastatic osteosarcoma who were treated at a single institution and achieved CR following PM, through univariate and multivariate analyses. Between January, 2000 and August, 2013, 62 patients with metastatic osteosarcoma were treated and followed up at our institution. A total of 25 patients achieved CR following PM and were included in this analysis. The 5-year OS and disease‑free survival following PM were 30 and 21%, respectively. The factors correlated with inferior OS in the univariate analysis included chondroblastic subtype, post‑chemotherapy necrosis <90% in the primary tumor, metastasis detected during neoadjuvant or adjuvant chemotherapy and pathological identification of tumor cells reaching the visceral pleural surface of any of the resected nodules. In the multivariate analysis, the chondroblastic subtype was the sole independent adverse prognostic factor (HR=4.6, 95% CI: 1.0‑21.3, P=0.044). Therefore, factors associated with tumor biology, including poor tumor necrosis in the primary tumor and detection of metastasis during primary chemotherapy, are associated with poor post-metastasectomy survival. In addition, chondroblastic subtype and visceral pleural involvement predicted poor prognosis in our series.
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Copy and paste a formatted citation
Spandidos Publications style
Salah S and Toubasi S: Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma. Mol Clin Oncol 3: 157-162, 2015.
APA
Salah, S., & Toubasi, S. (2015). Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma. Molecular and Clinical Oncology, 3, 157-162. https://doi.org/10.3892/mco.2014.426
MLA
Salah, S., Toubasi, S."Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma". Molecular and Clinical Oncology 3.1 (2015): 157-162.
Chicago
Salah, S., Toubasi, S."Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma". Molecular and Clinical Oncology 3, no. 1 (2015): 157-162. https://doi.org/10.3892/mco.2014.426
Copy and paste a formatted citation
x
Spandidos Publications style
Salah S and Toubasi S: Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma. Mol Clin Oncol 3: 157-162, 2015.
APA
Salah, S., & Toubasi, S. (2015). Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma. Molecular and Clinical Oncology, 3, 157-162. https://doi.org/10.3892/mco.2014.426
MLA
Salah, S., Toubasi, S."Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma". Molecular and Clinical Oncology 3.1 (2015): 157-162.
Chicago
Salah, S., Toubasi, S."Factors predicting survival following complete surgical remission of pulmonary metastasis in osteosarcoma". Molecular and Clinical Oncology 3, no. 1 (2015): 157-162. https://doi.org/10.3892/mco.2014.426
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