Assessment of health‑related quality of life of patients with esophageal squamous cell carcinoma following esophagectomy using EORTC quality of life questionnaires

Shen,Hongchang; Wang,Jue; Li,Wenhuan; Yi,Weiwei; Wang,Weibo

doi:10.3892/mco.2014.434

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

Assessment of health‑related quality of life of patients with esophageal squamous cell carcinoma following esophagectomy using EORTC quality of life questionnaires

Authors:
- Hongchang Shen
- Jue Wang
- Wenhuan Li
- Weiwei Yi
- Weibo Wang
View Affiliations / Copyright

Affiliations: Department of Chemotherapy, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
Pages: 133-138
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Published online on: October 1, 2014

https://doi.org/10.3892/mco.2014.434
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Abstract

Esophageal cancer is one of the leading causes of cancer‑related mortality and surgery is currently the main treatment modality for resectable esophageal cancer. To assess health‑related quality of life (HRQL) of patients with esophageal squamous cell carcinoma (ESCC) following esophagectomy, 62 consecutive patients with middle ESCC were randomly assigned into hand video‑assisted thoracoscopic surgery (HVATS) (n=33) and Ivor‑Lewis surgery (ILS) (n=29) groups. Quality of life questionnaires (QLQ)‑C30 and QLQ‑OES18, published by the European Organization for Research and Treatment of Cancer, were used prior to treatment and at regular intervals until 6 months following surgery. The results of QLQ‑C30 and QLQ‑OES18 demonstrated that i) patients with comorbidities and advanced tumor stage (III‑IV) exhibited increased risk of poor HRQL, while their gender, age, body mass index and anastomosis location were not associated with HRQL at 6 months after surgery; ii) all the patients had worse functional, symptom and global scores within 6 months after surgery; iii) patients in the HVATS group had similar baseline functional and symptom scores to those of patients in the ILS group; however, their functional and global scores were higher and their symptom scores were lower compared to those of patients in the ILS group; iv) the HRQL of patients in the HVATS group returned to preoperative levels within a shorter time period compared to patients in the ILS group. There were significant differences in global health, physical functioning, fatigue and pain scales between the two groups. In QLQ‑OES18, the dysphagia and gastroesophageal reflux scales were improved in both the HVATS and ILS groups, but no significant differences were observed between the two groups. In addition, the overall survival rate was similar in the two groups. Taken together, our findings indicated that HVATS is a safe procedure, associated with less disturbance to short‑term HRQL compared to ILS. Therefore, it appears reasonable to select HVATS for patients with early‑stage middle esophageal cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Assessment of health‑related quality of life of patients with esophageal squamous cell carcinoma following esophagectomy using EORTC quality of life questionnaires

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