Biomarkers for cancer‑related fatigue and adverse reactions to chemotherapy in lung cancer patients

Sha,Fei; Zhuang,Shanshan; Zhou,Li; Zhang,Liqun; Yang,Yuxian; Zhang,Shengqi; Jiang,Yi; Qiu,Guodong; Chen,Chen; Zheng,Jieting; Zhang,Shuyao

doi:10.3892/mco.2014.439

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

Biomarkers for cancer‑related fatigue and adverse reactions to chemotherapy in lung cancer patients

Authors:
- Fei Sha
- Shanshan Zhuang
- Li Zhou
- Liqun Zhang
- Yuxian Yang
- Shengqi Zhang
- Yi Jiang
- Guodong Qiu
- Chen Chen
- Jieting Zheng
- Shuyao Zhang
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Affiliations: Department of Pharmacy, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China, Department of Clinical Laboratory Medicine, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China, Department of Gynecological Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China, Department of IT, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China, Department of Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 505031, P.R. China
Pages: 163-166
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Published online on: October 8, 2014

https://doi.org/10.3892/mco.2014.439
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Abstract

This study was conducted to investigate the biomarkers that appear to be correlated with cancer‑related fatigue (CRF) and the adverse reactions (ADRs) to chemotherapy. A total of 100 lung cancer patients were selected and CRF prior to and following chemotherapy was evaluated. The plasma levels of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1 and the level of 17‑hydroxycorticosteroid (17‑OHCS) in the urine were analyzed and correlated with CRF and the ADRs associated with chemotherapy. The incidence of CRF was found to be 88.0% and ADRs following chemotherapy occurred in 15.0% of the patients. An increase in the TNF‑α and IL‑1 levels was detected in patients with CRF. The level of 17‑OHCS in the urine was found to be elevated in cases that experienced ADRs following chemotherapy. In conclusion, CRF is closely correlated with increased plasma levels of TNF‑α and IL‑1. Furthermore, an abnormally elevated 17‑OHCS level in the urine may be an important indicator predicting ADR development following chemotherapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Biomarkers for cancer‑related fatigue and adverse reactions to chemotherapy in lung cancer patients

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