Clinicopathological analysis of salivary gland carcinomas and literature review

Shigeishi,Hideo; Ohta,Kouji; Okui,Gaku; Seino,Sayaka; Hashikata,Miho; Yamamoto,Kazuhiro; Ishida,Yoko; Sasaki,Kazuki; Naruse,Takako; Rahman,Mohammad  Zeshaan; Uetsuki,Ryo; Nimiya,Akiko; Ono,Shigehiro; Shimasue,Hiroshi; Higashikawa,Koichiro; Sugiyama,Masaru; Takechi,Masaaki

doi:10.3892/mco.2014.441

January-February 2015 Volume 3 Issue 1

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January-February 2015 Volume 3 Issue 1

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Article

Clinicopathological analysis of salivary gland carcinomas and literature review

Authors:
- Hideo Shigeishi
- Kouji Ohta
- Gaku Okui
- Sayaka Seino
- Miho Hashikata
- Kazuhiro Yamamoto
- Yoko Ishida
- Kazuki Sasaki
- Takako Naruse
- Mohammad Zeshaan Rahman
- Ryo Uetsuki
- Akiko Nimiya
- Shigehiro Ono
- Hiroshi Shimasue
- Koichiro Higashikawa
- Masaru Sugiyama
- Masaaki Takechi
View Affiliations / Copyright

Affiliations: Department of Oral and Maxillofacial Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8553, Japan, Department of Public Oral Health, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734‑8553, Japan
Pages: 202-206
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Published online on: October 9, 2014

https://doi.org/10.3892/mco.2014.441
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Abstract

Malignant salivary gland tumors are rare and exhibit a broad spectrum of phenotypic heterogeneity. The objective of this study was to investigate prognostic factors in patients with salivary gland carcinomas and review the results in light of other reports. We retrospectively reviewed 40 patients with primary salivary gland carcinomas who were diagnosed and treated at our institution between 1991 and 2014. Of the 40 tumors, 19 (47.5%) were mucoepidermoid carcinomas, 11 (27.5%) were adenoid cystic carcinomas, 7 (17.5%) were acinic cell carcinomas, 2 (5.0%) were myoepithelial carcinomas and 1 (2.5%) was a squamous cell carcinoma. Clinically positive lymph nodes were present in 4 patients (10.0%). As regards clinical stage, 15 cases (37.5%) were stage I, 13 (32.5%) were stage II, 1 (2.5%) was stage III and 11 (27.5%) were stage IVA. The majority of the patients (97.5%) were treated with surgery, of whom 25 (62.5%) received surgery alone and 14 (35.0%) underwent surgery in combination with chemotherapy or chemotherapy and radiotherapy. The median follow‑up time for all the patients was 48 months. The disease‑specific survival rate at 5 years was 87.1%. We identified a significant correlation between poor survival rate and histological grade (intermediate/high), tumor size (T3/T4), lymph node metastasis (node‑positive) and clinical stage (III/IV) using the Kaplan‑Meier method (P<0.05 for each). In addition, the Cox proportional hazards regression analysis confirmed that lymph node metastasis and tumor size were independent prognostic factors for disease‑specific survival (hazard ratio = 18.7 and 15.1, respectively; P=0.023 and 0.037, respectively). Furthermore, tumor size was found to be a predictive factor regarding recurrence in the multivariate logistic regression analysis (odds ratio = 8.35; P=0.025). Our results suggest that lymph node metastasis and tumor size are significant prognostic factors for patients with salivary gland carcinomas.

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1	Ellis GL and Auclair PL: Classification of salivary gland neoplasmsSurgical Pathology of the Salivary Glands. Ellis GL, Auclair PL and Gnepp DR: WB Saunders; Philadelphia, PA: pp. 129–134. 1991
2	Spiro RH: Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 8:177–184. 1986.PubMed/NCBI
3	Speight PM and Barrett AW: Salivary gland tumours. Oral Dis. 8:229–240. 2002. View Article : Google Scholar : PubMed/NCBI
4	Thackray AC and Sobin LH: Histological typing of salivary gland tumoursInternational Histological Classification of Tumours. Thackray AC: 7th. World Health Organization: Geneva; 1972
5	Eveson JW, Auclair P, Gnepp DR and El-Naggar AK: Tumours of the salivary glandsWorld Health Organization Classification of Tumours. Barnes L, Eveson JW, Reichart P and Sidransky D: IARC Press; Lyon: pp. 212–215. 2005
6	Japan Society for Head and Neck Cancer, . General Rules for Clinical Studies on Head and Neck Cancer. 5th. Kanehara & Co Ltd.; Tokyo: 2012
7	Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours. 7th. Wiley-Blackwell; New York, NY: 2009
8	Jouzdani E, Yachouh J, Costes V, et al: Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution. Eur J Cancer. 46:323–331. 2010.
9	Regezi JA and Batsakis JG: Histogenesis of salivary gland neoplasms. Otolaryngol Clin North Am. 10:297–307. 1977.PubMed/NCBI
10	Ellis GL and Auclair PL: Tumors of the salivary glandsAtlas of Tumor Pathology. Armed Forces Institute of Pathology; (3rd Series). Washington, DC: pp. 80–94. 1996
11	Spiro RH: Factors affecting survival in salivary gland cancersControversies in the Management of Salivary Gland Disease. McGurk M and Renehan A: Oxford University Press; Oxford: pp. 143–150. 2001
12	Vander Poorten VL, Balm AJ, Hilgers FJ, Tan IB, Keus RB and Hart AA: Stage as major long term outcome predictor in minor salivary gland carcinoma. Cancer. 89:1195–1204. 2000.PubMed/NCBI
13	Vander Poorten VL, Balm AJ, Hilgers FJ, et al: The development of a prognostic score for patients with parotid carcinoma. Cancer. 85:2057–2067. 1999.
14	Renehan AG, Gleave EN, Slevin NJ and McGurk M: Clinico-pathological and treatment-related factors influencing survival in parotid cancer. Br J Cancer. 80:1296–1300. 1999. View Article : Google Scholar : PubMed/NCBI
15	Min R, Siyi L, Wenjun Y, et al: Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases. Int J Oral Maxillofac Surg. 41:952–957. 2012. View Article : Google Scholar : PubMed/NCBI
16	Bai S, Clubwala R, Adler E, et al: Salivary mucoepidermoid carcinoma: a multi-institutional review of 76 patients. Head Neck Pathol. 7:105–112. 2013. View Article : Google Scholar : PubMed/NCBI
17	Rapidis AD, Givalos N, Gakiopoulou H, et al: Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral Oncol. 43:130–136. 2007. View Article : Google Scholar : PubMed/NCBI
18	Bradley PJ: Distant metastases from salivary glands cancer. ORL J Otorhinolaryngol Relat Spec. 63:233–242. 2001. View Article : Google Scholar : PubMed/NCBI
19	Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S and Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol. 41:716–722. 2005. View Article : Google Scholar : PubMed/NCBI
20	Shigeishi H, Yoneda S, Taki M, et al: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep. 15:933–938. 2006.PubMed/NCBI
21	Shigeishi H, Sugiyama M, Tahara H, et al: Increased telomerase activity and hTERT expression in human salivary gland carcinomas. Oncol Lett. 2:845–850. 2011.PubMed/NCBI
22	Nasser SM, Faquin WC and Dayal Y: Expression of androgen, estrogen and progesterone receptors in salivary gland tumors. Frequent expression of androgen receptor in a subset of malignant salivary gland tumors. Am J Clin Pathol. 119:801–806. 2003. View Article : Google Scholar
23	Locati LD, Perrone F, Losa M, et al: Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). Oral Oncol. 45:986–990. 2009. View Article : Google Scholar : PubMed/NCBI
24	Locati LD, Bossi P, Perrone F, et al: Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study. Oral Oncol. 45:574–578. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinicopathological analysis of salivary gland carcinomas and literature review

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