Isolated metastases of hepatocellular carcinoma in the left atrium, unresponsive to treatment with sorafenib

Fukuoka,Kazuya; Masachika,Eriko; Honda,Miki; Tsukamoto,Yoshitane; Nakano,Takashi

doi:10.3892/mco.2014.454

Isolated metastases of hepatocellular carcinoma in the left atrium, unresponsive to treatment with sorafenib

Authors:
- Kazuya Fukuoka
- Eriko Masachika
- Miki Honda
- Yoshitane Tsukamoto
- Takashi Nakano
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Affiliations: Department of Medical Oncology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka 590‑0132, Japan, Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Published online on: November 10, 2014 https://doi.org/10.3892/mco.2014.454
Pages: 397-399

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Abstract

Isolated metastases in the left atrium that are discontinuous with an intrahepatic hepatocellular carcinoma (HCC) are extremely rare. This is the case report of a 46‑year‑old male patient with pulmonary metastases from HCC, who presented with a tumor in the left lung, extending to the left atrium through the left pulmonary vein. Two weeks after the initiation of treatment with sorafenib, the tumor metastasized to the left parietal cerebral lobe, with an intracranial hemorrhage. Although the patient underwent gamma knife radiosurgery for the metastatic brain tumor, his condition gradually deteriorated and he succumbed to multiple organ failure 4 months later. Given the severe complications that have been reported in patients with this type of metastasis, immediate multidisciplinary treatment, including surgical resection, should be considered.

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