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Article

Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

  • Authors:
    • Lei Huo
    • Xia Wang
    • Pamela K. Allen
    • Longyun Wang
    • Yuping Liao
    • Zaide Han
    • Liangfang Shen
    • Qingsong Tu
    • Meizuo Zhong
    • Yan Zhuang
    • Jing Li
    • Jidong Hong
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xiangya Hospital, Central South University, Institute of Skull Base Surgery and Neurooncology, Changsha, Hunan 410008, P.R. China, Department of Radiation Oncology, Xiangya Hospital, Central South University, Institute of Skull Base Surgery and Neurooncology, Changsha, Hunan 410008, P.R. China, Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, Department of Radiology, Xiangya Hospital, Central South University, Institute of Skull Base Surgery and Neurooncology, Changsha, Hunan 410008, P.R. China
  • Pages: 430-434
    |
    Published online on: November 20, 2014
       https://doi.org/10.3892/mco.2014.461
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Abstract

The aim of this study was to evaluate the predictors of long‑term survival following postoperative therapy for suprasellar germ cell tumors (GCTs). A total of 23 patients with pathologically confirmed suprasellar GCTs were reviewed between April, 1987 and October, 2008. The predictors were identified with a univariate Cox proportional hazards model and the results were used to group patients according to outcome. The overall survival (OS) and progression‑free survival (PFS) rates for the good- and poor‑prognosis two groups were estimated with Kaplan‑Meier analysis, with log‑rank tests used to assess differences between the groups. The OS rate for all patients was 82.6% at 5 and 72.9% at 10 years. Lesion size (2‑4 vs. >4 cm) and pathological type (pure germinoma vs. mixed GCT) were the only significant predictors of OS (P<0.05). The OS rate for the good‑prognosis group was 92.9% at both 5 and 10 years, whereas the corresponding rates for the poor‑prognosis group were 66.7 and 40.0%, respectively (P=0.020). The PFS rate for the good‑prognosis group was 92.9% at 5 and 85.7% at 10 years, whereas the corresponding PFS rates for the poor‑prognosis group were 44.4 and 33.3%, respectively (P=0.007). Lesion size and histology predicted outcome following postoperative therapy for suprasellar GCT. Therefore, pathological diagnosis is recommended whenever possible, as histology may dictate the choice of treatment.
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1 

Jia G, Luo SQ, Li CD and Ma ZY: Long-term effect of chemotherapy combined with radiotherapy in treatment of intracranial germinoma: report of 39 cases. Chin Med J. 83:198–200. 2003.(In Chinese).

2 

Echevarria ME, Fangusaro J and Goldman S: Pediatric central nervous system germ cell tumors: a review. Oncologist. 13:690–699. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Wang HW, Wu YH, Hsieh JY, et al: Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations. BMC Genomics. 11:1322010. View Article : Google Scholar : PubMed/NCBI

4 

Jaing TH, Wang HS, Hung IJ, et al: Intracranial germ cell tumors: a retrospective study of 44 children. Pediatr Neurol. 26:369–373. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Huh SJ, Shin KH, Kim IH, Ahn YC, Ha SW and Park CI: Radiotherapy of intracranial germinomas. Radiother Oncol. 38:19–23. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Aoyama H, Shirato H, Kakuto Y, et al: Pathologically-proven intracranial germinoma treated with radiation therapy. Radiother Oncol. 47:201–205. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Ogawa K, Shikama N, Toita T, et al: Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients. Int J Radiat Oncol Biol Phys. 58:705–713. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Shim KW, Kim TG, Suh CO, et al: Treatment failure in intracranial primary germinomas. Childs Nerv Syst. 23:1155–1161. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Eom KY, Kim IH, Park CI, et al: Upfront chemotherapy and involved-field radiotherapy results in more relapses than extended radiotherapy for intracranial germinomas: modification in radiotherapy volume might be needed. Int J Radiat Oncol Biol Phys. 71:667–671. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Cho J, Choi JU, Kim DS and Suh CO: Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma. Radiother Oncol. 91:75–79. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Jennings MT, Gelman R and Hochberg F: Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg. 63:155–167. 1985. View Article : Google Scholar : PubMed/NCBI

12 

Hoffman HJ, Otsubo H, Hendrick EB, et al: Intracranial germ-cell tumors in children. J Neurosurg. 74:545–551. 1991. View Article : Google Scholar : PubMed/NCBI

13 

Rychly B, Sidlova H and Danis D: The 2007 World Health Organisation classification of tumours of the central nervous system, comparison with 2000 classification. Cesk Patol. 44:35–36. 2008.(In Slovak). PubMed/NCBI

14 

Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Sung DI, Harisiadis L and Chang CH: Midline pineal tumors and suprasellar germinomas: highly curable by irradiation. Radiology. 128:745–751. 1978. View Article : Google Scholar : PubMed/NCBI

16 

Kanamori M, Kumabe T, Saito R, et al: Optimal treatment strategy for intracranial germ cell tumors: a single institution analysis. J Neurosurg Pediatr. 4:506–514. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kim JW, Kim WC, Cho JH, et al: A multimodal approach including craniospinal irradiation improves the treatment outcome of high-risk intracranial nongerminomatous germ cell tumors. Int J Radiat Oncol Biol Phys. 84:625–631. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Chao CK, Lee ST, Lin FJ, Tang SG and Leung WM: A multivariate analysis of prognostic factors in management of pineal tumor. Int J Radiat Oncol Biol Phys. 27:1185–1191. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MS and Sneed PK: Radiation therapy for primary intracranial germ-cell tumors. Int J Radiat Oncol Biol Phys. 32:943–949. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Hu YW, Huang PI, Wong TT, et al: Salvage treatment for recurrent intracranial germinoma after reduced-volume radiotherapy: a single-institution experience and review of the literature. Int J Radiat Oncol Biol Phys. 84:639–647. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ogawa K, Yoshii Y, Shikama N, et al: Spinal recurrence from intracranial germinoma: risk factors and treatment outcome for spinal recurrence. Int J Radiat Oncol Biol Phys. 72:1347–1354. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Shibamoto Y, Takahashi M and Abe M: Reduction of the radiation dose for intracranial germinoma: a prospective study. Br J Cancer. 70:984–989. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Chen MJ, Santos Ada S, Sakuraba RK, et al: Intensity-modulated and 3D-conformal radiotherapy for whole-ventricular irradiation as compared with conventional whole-brain irradiation in the management of localized central nervous system germ cell tumors. Int J Radiat Oncol Biol Phys. 76:608–614. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Chen YW, Huang PI, Ho DM, et al: Change in treatment strategy for intracranial germinoma: long-term follow-up experience at a single institute. Cancer. 118:2752–2762. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Khatua S, Dhall G, O'Neil S, et al: Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation. Pediatr Blood Cancer. 55:42–46. 2010.PubMed/NCBI

26 

Paximadis P, Hallock A, Bhambhani K, et al: Patterns of failure in patients with primary intracranial germinoma treated with neoadjuvant chemotherapy and radiotherapy. Pediatr Neurol. 47:162–166. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Kersh CR, Constable WC, Eisert DR, et al: Primary central nervous system germ cell tumors. Effect of histologic confirmation on radiotherapy. Cancer. 61:2148–2152. 1988. View Article : Google Scholar : PubMed/NCBI

28 

Sawamura Y: Current diagnosis and treatment of central nervous system germ cell tumours. Curr Opin Neurol. 9:419–423. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Kochi M and Ushio Y: Chemo-radiotherapy for malignant brain tumors. Cancer & chemotherapy. 29:669–676. 2002.(In Japanese).

30 

Matsutani M: Pineal germ cell tumors. Prog Neurol Surg. 23:76–85. 2009.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huo L, Wang X, Allen PK, Wang L, Liao Y, Han Z, Shen L, Tu Q, Zhong M, Zhuang Y, Zhuang Y, et al: Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors. Mol Clin Oncol 3: 430-434, 2015.
APA
Huo, L., Wang, X., Allen, P.K., Wang, L., Liao, Y., Han, Z. ... Hong, J. (2015). Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors. Molecular and Clinical Oncology, 3, 430-434. https://doi.org/10.3892/mco.2014.461
MLA
Huo, L., Wang, X., Allen, P. K., Wang, L., Liao, Y., Han, Z., Shen, L., Tu, Q., Zhong, M., Zhuang, Y., Li, J., Hong, J."Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors". Molecular and Clinical Oncology 3.2 (2015): 430-434.
Chicago
Huo, L., Wang, X., Allen, P. K., Wang, L., Liao, Y., Han, Z., Shen, L., Tu, Q., Zhong, M., Zhuang, Y., Li, J., Hong, J."Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors". Molecular and Clinical Oncology 3, no. 2 (2015): 430-434. https://doi.org/10.3892/mco.2014.461
Copy and paste a formatted citation
x
Spandidos Publications style
Huo L, Wang X, Allen PK, Wang L, Liao Y, Han Z, Shen L, Tu Q, Zhong M, Zhuang Y, Zhuang Y, et al: Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors. Mol Clin Oncol 3: 430-434, 2015.
APA
Huo, L., Wang, X., Allen, P.K., Wang, L., Liao, Y., Han, Z. ... Hong, J. (2015). Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors. Molecular and Clinical Oncology, 3, 430-434. https://doi.org/10.3892/mco.2014.461
MLA
Huo, L., Wang, X., Allen, P. K., Wang, L., Liao, Y., Han, Z., Shen, L., Tu, Q., Zhong, M., Zhuang, Y., Li, J., Hong, J."Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors". Molecular and Clinical Oncology 3.2 (2015): 430-434.
Chicago
Huo, L., Wang, X., Allen, P. K., Wang, L., Liao, Y., Han, Z., Shen, L., Tu, Q., Zhong, M., Zhuang, Y., Li, J., Hong, J."Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors". Molecular and Clinical Oncology 3, no. 2 (2015): 430-434. https://doi.org/10.3892/mco.2014.461
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