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Article

Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma

  • Authors:
    • Baitao Zhang
    • Fang Nie
    • Bin Jin
    • Qinghong Meng
    • Pin Dong
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, P.R. China, Department of Intensive Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, P.R. China
  • Pages: 392-396
    |
    Published online on: November 21, 2014
       https://doi.org/10.3892/mco.2014.464
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Abstract

Our objective was to conduct a systematic review and meta‑analysis of studies assessing the diagnostic performance of primary tumor standardized uptake value (SUV) in head and neck squamous cell carcinoma (HNSCC), as measured by positron emission tomography. A systematic search of the indexed medical literature was conducted using appropriate keywords to identify relevant studies. Six articles were identified by searching electronic databases. a statistical analysis was performed with RevMan 4.2.2 software. SUV measurement and the SUV threshold for defining high SUV were studied dependently. For each publication, we first obtained an estimate of the relative risk (RR) for comparing patients with a low and those with a high SUV. Subsequently, we aggregated the individual RRs into a combined RR using the fixed‑effects model to yield weighted mean pooled estimates with 95% confidence intervals (CIs). Publication bias was assessed with a funnel plot. A total of 6 clinical trials involving 453 patients were included in the meta‑analysis. The combined RR from the 6 reports for local control was 0.72 (95% CI: 0.63‑0.81). The funnel plot revealed symmetrical distribution, indicating no evidence of significant publication bias. The increase in the SUV of the primary tumor was found to be a poor prognostic marker for patients with HNSCC in the meta‑analysis, which requires further confirmation in a meta‑analysis based on individual patient data.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang B, Nie F, Jin B, Meng Q and Dong P: Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma. Mol Clin Oncol 3: 392-396, 2015.
APA
Zhang, B., Nie, F., Jin, B., Meng, Q., & Dong, P. (2015). Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma. Molecular and Clinical Oncology, 3, 392-396. https://doi.org/10.3892/mco.2014.464
MLA
Zhang, B., Nie, F., Jin, B., Meng, Q., Dong, P."Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma". Molecular and Clinical Oncology 3.2 (2015): 392-396.
Chicago
Zhang, B., Nie, F., Jin, B., Meng, Q., Dong, P."Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma". Molecular and Clinical Oncology 3, no. 2 (2015): 392-396. https://doi.org/10.3892/mco.2014.464
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Nie F, Jin B, Meng Q and Dong P: Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma. Mol Clin Oncol 3: 392-396, 2015.
APA
Zhang, B., Nie, F., Jin, B., Meng, Q., & Dong, P. (2015). Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma. Molecular and Clinical Oncology, 3, 392-396. https://doi.org/10.3892/mco.2014.464
MLA
Zhang, B., Nie, F., Jin, B., Meng, Q., Dong, P."Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma". Molecular and Clinical Oncology 3.2 (2015): 392-396.
Chicago
Zhang, B., Nie, F., Jin, B., Meng, Q., Dong, P."Pretreatment tumor standardized uptake value as a prognostic factor in primary head and neck squamous cell carcinoma". Molecular and Clinical Oncology 3, no. 2 (2015): 392-396. https://doi.org/10.3892/mco.2014.464
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