Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-2015 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2015 Volume 3 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma

  • Authors:
    • Melike Dinccelik‑Aslan
    • Guvem Gumus‑Akay
    • Atilla Halil Elhan
    • Ekrem Unal
    • Ajlan Tukun
  • View Affiliations / Copyright

    Affiliations: Biotechnology Institute, Ankara University, Golbasi, Ankara 06830, Turkey, Brain Research Centre, Ankara University, Mamak, Ankara 06900, Turkey, Department of Biostatistics, Faculty of Medicine, Ankara University, Sihhiye, Ankara 06100, Turkey, Department of Surgical Oncology, Research and Training Hospital, Faculty of Medicine, Ankara University, Cebeci, Ankara 06580, Turkey, Department of Medical Genetics, Faculty of Medicine, Ankara University, Sihhiye, Ankara 06100, Turkey
  • Pages: 584-590
    |
    Published online on: January 19, 2015
       https://doi.org/10.3892/mco.2015.486
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer‑related mortality. Previous studies revealed several genetic alterations specific to gastric cancer. In this study, we aimed to investigate the diagnostic and prognostic significance of the expression levels of the glypican 5 and glypican 6 genes (GPC5 and GPC6, respectively) in gastric cancer. For this purpose, GPC5 and GPC6 expression was quantitatively determined by quantitative polymerase chain reaction method in normal gastric mucosa and intestinal type gastric adenocarcinoma samples from 35 patients. The expression levels of GPC5 and GPC6 were compared between normal and tumor tissues. Additionally, the association of the expression levels in tumor tissues with several clinicopathological parameters was evaluated. Although GPC5 was not expressed in any of the samples, the expression of GPC6, which was detected in both groups, was found to be significantly higher in tumor tissues compared to that in normal samples (P=0.039). However, there was no statistically significant association between GPC6 expression and any of the clinicopathological parameters investigated (P>0.05). Our findings suggested that an increase in GPC6 expression levels may be implicated in gastric cancer development, but not in cancer progression.
View Figures

Figure 1

View References

1 

GLOBOCAN, . Cancer Incidence and Mortality Worldwide in 2008. http://globocan.iarc.frAccessed. February ??–2009

2 

Stock M and Otto F: Gene deregulation in gastric cancer. Gene. 360:1–19. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Zheng L, Wang L, Ajani J and Xie E: Molecular basis of gastric cancer development and progression. Gastric Cancer. 7:61–77. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N and Stratton MR: A census of human cancer genes. Nat Rev Cancer. 4:177–183. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Scartozzi M, Galizia E, Freddari F, Berardi R, Cellerino R and Cascinu S: Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches. Cancer Treat Rev. 30:451–459. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Gumus-Akay G, Unal AE, Elhan AH, Bayar S, Karadayt K, Sunguroglu A, Kadikiran A and Tukun A: DNA copy number changes in gastric adenocarcinomas: high resolution-comparative genomic hybridization study in Turkey. Arch Med Res. 40:551–560. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Syrokou A, Tzanakakis G, Tsegenidis T, Hjerpe A and Karamanos NK: Effects of glycosaminoglycans on proliferation of epithelial and fibroblast human malignant mesothelioma cells: a structure-function relationship. Cell Prolif. 32:85–99. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Kirn-Safran C, Farach-Carson MC and Carson DD: Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans. Cell Mol Life Sci. 66:3421–3434. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Jackson RL, Busch SJ and Cardin AD: Glycosaminoglycans: molecular properties, protein interactions and role in physiological processes. Physiol Rev. 71:481–539. 1991.PubMed/NCBI

10 

De Cat B and David G: Developmental roles of the glypicans. Semin Cell Dev Biol. 12:117–125. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Saunders S, Paine-Saunders S and Lander AD: Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 190:78–93. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Yayon A, Klagsbrun M, Esko JD, Leder P and Ornitz DM: Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 64:841–848. 1991. View Article : Google Scholar : PubMed/NCBI

13 

Cumberledge S and Reichsman F: Glycosaminoglycans and WNTs: just a spoonful of sugar helps the signal go down. Trends Genet. 13:421–423. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Fuster MM and Esko JD: The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer. 5:526–542. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Hsu HC, Cheng W and Lai PL: Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. Cancer Res. 57:5179–5184. 1997.PubMed/NCBI

16 

Ning S, Bin C, Na H, et al: Glypican-3, a novel prognostic marker of hepatocellular cancer, is related with postoperative metastasis and recurrence in hepatocellular cancer patients. Mol Biol Rep. 39:351–357. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Ozkan H, Erdal H, Kocak E, Tutkak H, Karaeren Z, Yakut M and Koklu S: Diagnostic and prognostic role of serum glypican 3 in patients with hepatocellular carcinoma. J Clin Lab Anal. 25:350–353. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zhang L, Liu H, Sun L, Li N, Ding H and Zheng J: Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: a tissue microarray-based study. Acta Histochem. 114:547–552. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Liu S, Li Y, Chen W, Zheng P, Liu T, He W, Zhang J and Zeng X: Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 419:656–661. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Li Y and Yang P: GPC5 gene and its related pathways in lung cancer. J Thorac Oncol. 6:2–5. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Su G, Meyer K, Nandini CD, Qiao D, Salamat S and Friedl A: Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol. 168:2014–2026. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Kleeff J, Ishiwata T, Kumbasar A, Friess H, Buchler MW, Lander AD and Korc M: The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest. 102:1662–1673. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Midorikawa Y, Ishikawa S, Iwanari H, Imamura T, Sakamoto H, Miyazono K, Kodama T, Makuuchi M and Aburatani H: Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. Int J Cancer. 103:455–465. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Capurro MI, Xiang YY, Lobe C and Filmus J: Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. Cancer Res. 65:6245–6254. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Filmus J and Selleck SB: Glypicans: proteoglycans with a surprise. J Clin Invest. 108:497–501. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Sung YK, Hwang SY, Farooq M, Kim JC and Kim MK: Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling. Exp Mol Med. 35:257–262. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Williamson D, Selfe J, Gordon T, Lu YJ, Pritchard-Jones K, Murai K, Jones P, Workman P and Shipley J: Role for amplification and expression of glypican-5 in rhabdomyosarcoma. Cancer Res. 67:57–65. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Yiu GK, Kaunisto A, Chin YR and Toker A: NFAT promotes carcinoma invasive migration through glypican-6. Biochem J. 440:157–166. 2011. View Article : Google Scholar : PubMed/NCBI

29 

WHO Cancer Fact sheet N°297, . World Health Organization. http://www.who.int/mediacentre/factsheets/fs297/en/Accessed. February. 2009

30 

Garziera M, De Re V, Geremia S, et al: A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy. Clin Exp Med. 13:149–157. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Kang JM, Lee BM, Kim N, Lee HS, Lee HE, Park JH, Kim JS, Jung HC and Song IS: CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer. J Korean Med Sci. 26:647–653. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Tsapralis D, Panayiotides I, Peros G, Liakakos T and Karamitopoulou E: Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology. World J Gastroenterol. 18:150–155. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Furuta K, Arao T, Sakai K, et al: Integrated analysis of whole genome exon array and array-comparative genomic hybridization in gastric and colorectal cancer cells. Cancer Sci. 103:221–227. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Leal MF, Calcagno DQ, Borges da Costa J de F, Silva TC, Khayat AS, Chen ES, Assumpcao PP, de Arruda Cardoso Smith M and Burbano RR: MYC, TP53, and chromosome 17 copy-number alterations in multiple gastric cancer cell lines and in their parental primary tumors. J Biomed Biotechnol. 2011:6312682011. View Article : Google Scholar : PubMed/NCBI

35 

Ye YW, Wu JH, Wang CM, Zhou Y, Du CY, Zheng BQ, Cao X, Zhou XY, Sun MH and Shi YQ: Sox 17 regulates proliferation and cell cycle during gastric cancer progression. Cancer Lett. 307:124–131. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Hileman RE, Fromm JR, Weiler JM and Linhardt RJ: Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins. Bioessays. 20:156–167. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Higashiyama S, Abraham JA and Klagsbrun M: Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate. J Cell Biol. 122:933–940. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Jackson SM, Nakato H, Sugiura M, Jannuzi A, Oakes R, Kaluza V, Golden C and Selleck SB: Dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen. Dpp. Development. 124:4113–4120. 1997.

39 

Godin RE, Takaesu NT, Robertson EJ and Dudley AT: Regulation of BMP7 expression during kidney development. Development. 125:3473–3482. 1998.PubMed/NCBI

40 

Yu W, Inoue J, Imoto I, Matsuo Y, Karpas A and Inazawa J: GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. J Hum Genet. 48:331–335. 2003.PubMed/NCBI

41 

Li Y, Sheu CC, Ye Y, et al: Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol. 11:321–330. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Li F, Shi W, Capurro M and Filmus J: Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling. J Cell Biol. 192:691–704. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Kumar A, White TA, MacKenzie AP, et al: Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc Natl Acad Sci USA. 108:17087–17092. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Lau CS, Yu CB, Wong HK, et al: Allelic imbalance at 13q31 is associated with reduced GPC6 in Chinese with sporadic retinoblastoma. Br J Ophthalmol. 94:357–362. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Lacrima K: Role of glypican-6 and NG2 as metastasis promoting factors. Universita' Degli Studi Di ParmaDottorato di ricerca in Fisiopatologia Sistemica2005, PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dinccelik‑Aslan M, Gumus‑Akay G, Elhan AH, Unal E and Tukun A: Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma. Mol Clin Oncol 3: 584-590, 2015.
APA
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A.H., Unal, E., & Tukun, A. (2015). Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma. Molecular and Clinical Oncology, 3, 584-590. https://doi.org/10.3892/mco.2015.486
MLA
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A. H., Unal, E., Tukun, A."Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma". Molecular and Clinical Oncology 3.3 (2015): 584-590.
Chicago
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A. H., Unal, E., Tukun, A."Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma". Molecular and Clinical Oncology 3, no. 3 (2015): 584-590. https://doi.org/10.3892/mco.2015.486
Copy and paste a formatted citation
x
Spandidos Publications style
Dinccelik‑Aslan M, Gumus‑Akay G, Elhan AH, Unal E and Tukun A: Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma. Mol Clin Oncol 3: 584-590, 2015.
APA
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A.H., Unal, E., & Tukun, A. (2015). Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma. Molecular and Clinical Oncology, 3, 584-590. https://doi.org/10.3892/mco.2015.486
MLA
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A. H., Unal, E., Tukun, A."Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma". Molecular and Clinical Oncology 3.3 (2015): 584-590.
Chicago
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A. H., Unal, E., Tukun, A."Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma". Molecular and Clinical Oncology 3, no. 3 (2015): 584-590. https://doi.org/10.3892/mco.2015.486
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team