Insulin‑like growth factor 1 receptor expression in breast cancer tissue and mammographic density

Sun,Woo‑Young; Yun,Hyo‑Young; Song,Young‑Jin; Kim,Heon; Lee,Ok‑Jun; Nam,Seok‑Jin; Koo,Ja‑Seung

doi:10.3892/mco.2015.497

Insulin‑like growth factor 1 receptor expression in breast cancer tissue and mammographic density

Authors:
- Woo‑Young Sun
- Hyo‑Young Yun
- Young‑Jin Song
- Heon Kim
- Ok‑Jun Lee
- Seok‑Jin Nam
- Ja‑Seung Koo
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Affiliations: Department of Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon 301‑723, Republic of Korea, Department of Surgery, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361‑763, Republic of Korea , Department of Preventive Medicine, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361‑763, Republic of Korea , Department of Pathology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungcheong 361‑763, Republic of Korea , Department of Surgery, Samsung Medical Center, Seoul 135‑710, Republic of Korea, Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul 120‑752, Republic of Korea
Published online on: January 27, 2015 https://doi.org/10.3892/mco.2015.497
Pages: 572-580

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Abstract

The aim of this study was to evaluate the association between insulin‑like growth factor 1 receptor (IGF‑1R) expression in breast cancer tissue and mammographic density and the clinical significance of IGF‑1R overexpression. A total of 167 patients with primary invasive breast cancer were analyzed. Mammographic breast density and IGF‑1R overexpression were correlated with clinicopathological parameters and analyzed by overall survival (OS) and disease‑free survival (DFS). Increased breast tissue density was significantly associated with age, body mass index, menopausal status, histological grade and IGF‑1R overexpression in the univariate analysis and with age (P=0.001), histological grade (P=0.045) and IGF‑1R overexpression (P=0.021) in the multivariate analysis. IGF‑1R overexpression was significantly associated with dense breast tissue in patients aged >40 years (P=0.002). IGF‑1R overexpression in breast cancer in premenopausal women was associated with human epidermal growth factor receptor 2 (HER‑2) positivity (P=0.016) and worse DFS (P=0.0414). There was no significant difference in OS and DFS between dense and non‑dense breast tissue. IGF‑1R expression in breast cancer tissue was significantly associated with mammographic breast tissue density in patients aged >40 years. It appears that IGF‑1R expression in breast cancer tissue plays an important role in breast cancer in patients with dense breast tissue. In premenopausal women, IGF‑1R overexpression in breast cancer tissue was significantly associated with HER‑2 positivity and poor DFS.

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