Postoperative brachytherapy and electron beam irradiation for keloids: A single institution retrospective analysis

Duan,Qiwen; Liu,Junhua; Luo,Zhiguo; Hu,Chenhao

doi:10.3892/mco.2015.498

May-2015 Volume 3 Issue 3

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May-2015 Volume 3 Issue 3

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Article

Postoperative brachytherapy and electron beam irradiation for keloids: A single institution retrospective analysis

Authors:
- Qiwen Duan
- Junhua Liu
- Zhiguo Luo
- Chenhao Hu
View Affiliations / Copyright

Affiliations: Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Paediatrics and Epidemiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
Pages: 550-554
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Published online on: January 27, 2015

https://doi.org/10.3892/mco.2015.498
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Abstract

The aim of the present study was to perform a retrospective analysis of the control rate and toxicity of postoperative brachytherapy and electron beam irradiation for keloids. A retrospective review was performed of 116 keloid patients who underwent postoperative brachytherapy and electron beam irradiation between January 1, 2002 and June 30, 2012. Several different radiotherapy techniques and fractionation schedules were performed in the analysis, including high‑dose rate (HDR) irradiation with 192Ir at 8 Gy/1 fraction (F)+9 Gy/3F or 20 Gy/4F; HDR brachytherapy with 60Co at 20 Gy/4F or 18 Gy/6F; or external beam electron therapy at 26 Gy/13F or 30 Gy/15F. The endpoints of the study were analysis of the control rate and toxicity. The median observation period was 46.5 months (range, 10.0‑120.0 months) for all patients. In total, 18 of the 116 patients relapsed, and 16.7 months (range, 10.0‑30.0 months) was the median time to recurrence for these patients. The control rates for the patients who received hypofractionation (>2 Gy per fraction) and conventional fraction (2 Gy per fraction) were 88.5 and 76.3%, respectively (P=0.043). The control rates for the patients whose calculated biological effective doses (BED) were >30 Gy and <30 Gy were 89.7 and 79.3%, respectively (P=0.104). There were no grade 2 or higher adverse effects based on the Common Terminology Criteria for Adverse Events v3.0 in the late phase. No evidence was identified for a link between radiotherapy and the subsequent occurrence of cancer. The results of the present study indicate that hypofractionated radiotherapy played an important role as an adjuvant therapy following surgical excision of keloids. A BED of >30 Gy appears to be sufficient. No definitive evidence was found for an association between radiotherapy and the occurrence of cancer during the follow‑up, however, more cases and longer follow‑up periods are required.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Postoperative brachytherapy and electron beam irradiation for keloids: A single institution retrospective analysis

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