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Article

Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects

  • Authors:
    • Lan Wu
    • Xing Gao
    • Dongxia Ye
    • Yewei Ding
    • Xi Yang
    • Wei Liu
  • View Affiliations / Copyright

    Affiliations: Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, P.R. China, Department of Oral and Maxillofacial Surgery, XiangYa Hospital, Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 649-654
    |
    Published online on: February 18, 2015
       https://doi.org/10.3892/mco.2015.513
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Abstract

The XPA gene participates in modulating DNA damage recognition during the DNA nucleotide excision repair process. Current data regarding the association of the XPA A23G polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) remain controversial, and meta‑analyses focusing on the HNSCC risk and this polymorphism are limited. Therefore, the aim of the present study was to derive a more precise estimation of this association by a meta‑analysis of all the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CI) were assessed for the strength of the associations in eight studies, including 5,491 subjects (2,409 HNSCC cases and 3,082 controls). The overall analysis revealed that the XPA A23G polymorphism was not significantly associated with the overall HNSCC risk. Consistently, there was no evidence for the association between the XPA A23G polymorphism and HNSCC risk in subgroup analyses based on ethnicity and the source of controls. However, the significant associations in oral carcinoma with the increased risk among the XPA heterozygote (AG vs. AA: OR, 1.58; 95% CI, 1.06‑2.37; Pheterogeneity=0.23, I2=30%) and dominant (AG +GG vs. AA: OR, 1.53; 95% CI, 1.04‑2.23; Pheterogeneity=0.21, I2=36%) models were observed in the subgroup analysis by tumor site. In conclusion, the meta‑analysis suggested that the XPA A23G polymorphism was not associated with overall HNSCC susceptibility, but it was associated with oral carcinoma susceptibility and it may be a risk factor for oral carcinoma. Further well‑designed and large studies are required to confirm these associations.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Marur S, D'Souza G, Westra WH and Forastiere AA: Hpv-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 11:781–789. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Marron M, Boffetta P, Zhang ZF, et al: Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol. 39:182–196. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Leemans CR, Braakhuis BJ and Brakenhoff RH: The molecular biology of head and neck cancer. Nat Rev Cancer. 11:9–22. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Shell SM, Li Z, Shkriabai N, Kvaratskhelia M, et al: Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem. 284:24213–24222. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Vaid M, Sharma SD and Katiyar SK: Proanthocyanidins inhibit photocarcinogenesis through enhancement of DNA repair and xeroderma pigmentosum group A-dependent mechanism. Cancer Prev Res (Phila). 3:1621–1629. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Krasikova YS, Rechkunova NI, Maltseva EA, Petruseva IO and Lavrik OI: Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair. Nucleic Acids Res. 38:8083–8094. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Liu J, Zhang Z, Cao XL, et al: XPA A23G polymorphism and susceptibility to cancer: a meta-analysis. Mol Biol Rep. 39:6791–6799. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ding D, Zhang Y, Yu H, et al: Genetic variation of XPA gene and risk of cancer: a systematic review and pooled analysis. Int J Cancer. 131:488–496. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Lou Y, Li R, Zhang Y, et al: XPA gene rs1800975 single nucleotide polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 35:6607–6617. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Sugimura T, Kumimoto H, Tohnai I, et al: Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med. 35:11–18. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Hall J, Hashibe M, Boffetta P, et al: The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract. Carcinogenesis. 28:665–671. 2006. View Article : Google Scholar : PubMed/NCBI

13 

An J, Liu Z, Hu Z, et al: Potentially functional single nucleotide polymorphisms in the core nucleotide excision repair genes and risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev. 16:1633–1638. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Bau DT, Tsai MH, Huang CY, et al: Relationship between polymorphisms of nucleotide excision repair genes and oral cancer risk in Taiwan: evidence for modification of smoking habit. Chin J Physiol. 50:294–300. 2007.PubMed/NCBI

15 

Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P and Popanda O: Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Int J Cancer. 125:1431–1439. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Jelonek K, Gdowicz-Klosok A, Pietrowska M, et al: Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck and breast cancers in a Polish population. J Appl Genet. 51:343–352. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Lu B, Li J, Gao Q, Yu W, Yang Q and Li X: Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. Gene. 542:64–68. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Li X, Xu J, Yang X, et al: Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking. Tumour Biol. 35:4659–4665. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zhang L, Wang Y, Qiu Z, Luo J, Zhou Z and Shu W: The XRCC1 Arg194Trp polymorphism is not a risk factor for glioma: A meta-analysis involving 1,440 cases and 2,562 controls. Exp Ther Med. 4:1057–1062. 2012.PubMed/NCBI

20 

Zhuo XL, Ling JJ, Zhao HY, Zhou Y, Song YF and Tan YH: Lack of association of the cyclin D1 G870A variation with oral carcinoma risk: Evidence from 2,404 subjects. Exp Ther Med. 4:748–754. 2012.PubMed/NCBI

21 

Schena M, Guarrera S, Buffoni L, et al: DNA repair gene expression level in peripheral blood and tumour tissue from non-small cell lung cancer and head and neck squamous cell cancer patients. DNA Repair (Amst). 11:374–380. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Azad AK, Bairati I, Samson E, et al: Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival. Clin Cancer Res. 18:196–206. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Song X, Sturgis EM, Jin L, Wang Z, Wei Q and Li G: Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. Int J Cancer. 133:695–704. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu L, Gao X, Ye D, Ding Y, Yang X and Liu W: Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects. Mol Clin Oncol 3: 649-654, 2015.
APA
Wu, L., Gao, X., Ye, D., Ding, Y., Yang, X., & Liu, W. (2015). Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects. Molecular and Clinical Oncology, 3, 649-654. https://doi.org/10.3892/mco.2015.513
MLA
Wu, L., Gao, X., Ye, D., Ding, Y., Yang, X., Liu, W."Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects". Molecular and Clinical Oncology 3.3 (2015): 649-654.
Chicago
Wu, L., Gao, X., Ye, D., Ding, Y., Yang, X., Liu, W."Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects". Molecular and Clinical Oncology 3, no. 3 (2015): 649-654. https://doi.org/10.3892/mco.2015.513
Copy and paste a formatted citation
x
Spandidos Publications style
Wu L, Gao X, Ye D, Ding Y, Yang X and Liu W: Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects. Mol Clin Oncol 3: 649-654, 2015.
APA
Wu, L., Gao, X., Ye, D., Ding, Y., Yang, X., & Liu, W. (2015). Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects. Molecular and Clinical Oncology, 3, 649-654. https://doi.org/10.3892/mco.2015.513
MLA
Wu, L., Gao, X., Ye, D., Ding, Y., Yang, X., Liu, W."Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects". Molecular and Clinical Oncology 3.3 (2015): 649-654.
Chicago
Wu, L., Gao, X., Ye, D., Ding, Y., Yang, X., Liu, W."Association of the XPA A23G polymorphism with the risk of head and neck carcinomas: Evidence from 5,491 subjects". Molecular and Clinical Oncology 3, no. 3 (2015): 649-654. https://doi.org/10.3892/mco.2015.513
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