Effect of particle beam radiotherapy on locally recurrent rectal cancer: Three case reports

Mokutani,Yukako; Yamamoto,Hirofumi; Uemura,Mamoru; Haraguchi,Naotsugu; Takahashi,Hidekazu; Nishimura,Junichi; Hata,Taishi; Takemasa,Ichiro; Mizushima,Tsunekazu; Doki,Yuichiro; Mori,Masaki

doi:10.3892/mco.2015.532

July-2015 Volume 3 Issue 4

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July-2015 Volume 3 Issue 4

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Case Report

Effect of particle beam radiotherapy on locally recurrent rectal cancer: Three case reports

Authors:
- Yukako Mokutani
- Hirofumi Yamamoto
- Mamoru Uemura
- Naotsugu Haraguchi
- Hidekazu Takahashi
- Junichi Nishimura
- Taishi Hata
- Ichiro Takemasa
- Tsunekazu Mizushima
- Yuichiro Doki
- Masaki Mori
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Affiliations: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan
Pages: 765-769
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Published online on: March 30, 2015

https://doi.org/10.3892/mco.2015.532
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Abstract

Surgical resection is the most effective therapy for locally recurrent rectal cancer (LRRC); however, it often necessitates invasive procedures that may lead to major complications. Particle beam radiotherapy (RT), including carbon ion RT (C‑ion RT) and proton beam RT, is a promising new modality that exhibits considerable efficacy against various types of human cancer. C‑ion RT reportedly offers a therapeutic alternative for LRRC. In the present study, we describe three cases of LRRC treated by particle beam RT. In all the cases, LRRC was diagnosed by computed tomography, magnetic resonance imaging and positron emission tomography imaging. No serious adverse effects were observed during RT. One patient experienced re‑recurrence of LRRC, but survived for 6 years following particle beam RT; the second patient remains recurrence‑free after a 2‑year follow‑up; and the third patient has developed recurrence at different sites in the pelvis but, to date, has survived for 4 years following particle beam RT. Therefore, LRRC was controlled by particle beam RT in two of the three cases, suggesting that particle beam RT is a safe alternative treatment for patients with LRRC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of particle beam radiotherapy on locally recurrent rectal cancer: Three case reports

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