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Molecular and Clinical Oncology
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July-2015 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy

  • Authors:
    • Makoto Ishitobi
    • Mizuho Shiba
    • Takahiro Nakayama
    • Hiroki Koyama
    • Yasuhiro Tamaki
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537‑8511, Japan
  • Pages: 843-846
    |
    Published online on: March 30, 2015
       https://doi.org/10.3892/mco.2015.534
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Abstract

The effect of prior endocrine therapy on tumor biology and clinical outcomes of locoregional recurrence remains unclear. A total of 76 patients, who underwent salvage breast surgery for estrogen receptor‑positive ipsilateral breast tumor recurrence (IBTR) following breast‑conserving surgery for primary breast cancer, were retrospectively reviewed to investigate the association of human epidermal growth factor receptor 2 (HER2) status with the characteristics of IBTR and clinical outcomes following resection of IBTR. There was a tendency for more patients with HER2‑positive IBTR to show resistance to endocrine therapy (71.4%) compared with those with HER2‑negative IBTR (37.3%) (P=0.085). Patients with HER2‑positive IBTR exhibited a higher rate of recurrence (62.5%) compared with those with HER2‑negative IBTR (25.0%) (P=0.027). These results suggested that HER2‑positive IBTR may be associated with resistance to endocrine therapy and a poorer clinical outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Ishitobi M, Shiba M, Nakayama T, Koyama H and Tamaki Y: Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy. Mol Clin Oncol 3: 843-846, 2015.
APA
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., & Tamaki, Y. (2015). Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy. Molecular and Clinical Oncology, 3, 843-846. https://doi.org/10.3892/mco.2015.534
MLA
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., Tamaki, Y."Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy". Molecular and Clinical Oncology 3.4 (2015): 843-846.
Chicago
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., Tamaki, Y."Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy". Molecular and Clinical Oncology 3, no. 4 (2015): 843-846. https://doi.org/10.3892/mco.2015.534
Copy and paste a formatted citation
x
Spandidos Publications style
Ishitobi M, Shiba M, Nakayama T, Koyama H and Tamaki Y: Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy. Mol Clin Oncol 3: 843-846, 2015.
APA
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., & Tamaki, Y. (2015). Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy. Molecular and Clinical Oncology, 3, 843-846. https://doi.org/10.3892/mco.2015.534
MLA
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., Tamaki, Y."Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy". Molecular and Clinical Oncology 3.4 (2015): 843-846.
Chicago
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., Tamaki, Y."Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy". Molecular and Clinical Oncology 3, no. 4 (2015): 843-846. https://doi.org/10.3892/mco.2015.534
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