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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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July-2015 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma

  • Authors:
    • Leonardo Gomes da Fonseca
    • Romualdo Barroso‑Sousa
    • Afonso da Silva Alves Bento
    • Bruna Paccola Blanco
    • Gabriel Luis Valente
    • Tulio Eduardo Flesch Pfiffer
    • Paulo Marcelo Hoff
    • Jorge Sabbaga

  • View Affiliations / Copyright

    Affiliations: Cancer Institute of the State of Sao Paulo, University of Sao Paulo, Sao Paulo, SP 01255‑000, Brazil
  • Pages: 793-796
    |
    Published online on: April 2, 2015
       https://doi.org/10.3892/mco.2015.536
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Abstract

Sorafenib demonstrated a survival benefit in the treatment of advanced hepatocellular carcinoma (HCC) in phase III trials. However, almost all the patients included in those trials exhibited well‑preserved liver function (Child‑Pugh A). The aim of this study was to describe our experience with sorafenib in Child‑Pugh B HCC patients. A database of patients with advanced HCC treated with sorafenib was retrospectively evaluated. The median overall survival of Child‑Pugh B patients (n=20) was 2.53 months [95% confidence interval (CI): 0.33‑5.92 months] and of Child‑Pugh A patients (n=100) 9.71 months (95% CI: 6.22‑13.04). Child‑Pugh B patients had a significantly poorer survival compared to Child‑Pugh A patients (P=0.002). The toxicities were similar between the two groups. Metastasis, vascular invasion and α‑fetoprotein level >1,030 ng/ml were not associated with survival among Child‑Pugh B patients (P=0.281, 0.189 and 0.996, respectively). Although the survival outcomes were worse in Child‑Pugh B patients treated with sorafenib, the toxicity profile was manageable. Therefore, there remains the question of whether to treat this subgroup of patients and more data are required to define the role of sorafenib in the context of liver dysfunction.
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Copy and paste a formatted citation
Spandidos Publications style
da Fonseca LG, Barroso‑Sousa R, Bento Ad, Blanco BP, Valente GL, Pfiffer TE, Hoff PM and Sabbaga J: Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma. Mol Clin Oncol 3: 793-796, 2015.
APA
da Fonseca, L.G., Barroso‑Sousa, R., Bento, A.d., Blanco, B.P., Valente, G.L., Pfiffer, T.E. ... Sabbaga, J. (2015). Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma. Molecular and Clinical Oncology, 3, 793-796. https://doi.org/10.3892/mco.2015.536
MLA
da Fonseca, L. G., Barroso‑Sousa, R., Bento, A. d., Blanco, B. P., Valente, G. L., Pfiffer, T. E., Hoff, P. M., Sabbaga, J."Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma". Molecular and Clinical Oncology 3.4 (2015): 793-796.
Chicago
da Fonseca, L. G., Barroso‑Sousa, R., Bento, A. d., Blanco, B. P., Valente, G. L., Pfiffer, T. E., Hoff, P. M., Sabbaga, J."Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma". Molecular and Clinical Oncology 3, no. 4 (2015): 793-796. https://doi.org/10.3892/mco.2015.536
Copy and paste a formatted citation
x
Spandidos Publications style
da Fonseca LG, Barroso‑Sousa R, Bento Ad, Blanco BP, Valente GL, Pfiffer TE, Hoff PM and Sabbaga J: Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma. Mol Clin Oncol 3: 793-796, 2015.
APA
da Fonseca, L.G., Barroso‑Sousa, R., Bento, A.d., Blanco, B.P., Valente, G.L., Pfiffer, T.E. ... Sabbaga, J. (2015). Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma. Molecular and Clinical Oncology, 3, 793-796. https://doi.org/10.3892/mco.2015.536
MLA
da Fonseca, L. G., Barroso‑Sousa, R., Bento, A. d., Blanco, B. P., Valente, G. L., Pfiffer, T. E., Hoff, P. M., Sabbaga, J."Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma". Molecular and Clinical Oncology 3.4 (2015): 793-796.
Chicago
da Fonseca, L. G., Barroso‑Sousa, R., Bento, A. d., Blanco, B. P., Valente, G. L., Pfiffer, T. E., Hoff, P. M., Sabbaga, J."Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma". Molecular and Clinical Oncology 3, no. 4 (2015): 793-796. https://doi.org/10.3892/mco.2015.536
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