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Article

Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats

  • Authors:
    • Maria Ines Da Cruz Campos
    • Wellington Dorigheto Andrade Vieira
    • Celso Neiva Campos
    • Fernando Monteiro Aarestrup
    • Beatriz Julião Vieira Aarestrup
  • View Affiliations / Copyright

    Affiliations: Postgraduate Program in Health, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil, School of Dentistry, Faculty of Medical and Health Sciences (PPGS), Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil, Department of Dental Clinic, Dental Scool, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil, Laboratory of Immunopathology and Clinical Immunology, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
  • Pages: 825-828
    |
    Published online on: April 9, 2015
       https://doi.org/10.3892/mco.2015.544
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Abstract

Malignant neoplasia represents the second cause of disease‑related mortality and, among all patients diagnosed with cancer, 70% will receive chemotherapy during the course of treatment. As a consequence, an increasing number of researchers have focused their attention on the search for more specific anticancer therapies associated with fewer side effects. Leukopenia is an important adverse effect associated with chemotherapy. Secondary infection is very common among leukopenic patients, directly affecting the continuity of the chemotherapeutic treatment and leading to possible complications in tumor immune defense. Atorvastatin, a type of statin, is a known agent used to control hypercholesterolemia. Trans‑caryophyllene, isolated from a resinous oil extracted from the copaiba tree, possesses anti‑inflammatory and analgesic properties. The aim of the present study was to evaluate, through a complete leukocyte count, the systemic immunomodulation potential of pentoxifylline (PTX), atorvastatin and trans‑caryophyllene, as well as the possible prophylactic role of these drugs against secondary leukopenia, in an experimental chemotherapy model induced by 5‑fluorouracil (5‑FU) in Wistar rats. A total of 32 male Wistar rats were used, 24 of which were submitted to treatment with atorvastatin, PTX and trans‑caryophyllene prior to the administration of chemotherapy. The Shapiro‑Wilk test was used to verify normality and the Kruskal‑Wallis test was used for negative data in the normality test. Among the drugs selected, atorvastatin exhibited the best preventive potential in regards to leukopenia secondary to experimental chemotherapy induced by 5‑FU, in comparison to the group receiving saline solution, while PTX amplified such alterations in the leukograms of the animals in this trial.
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Copy and paste a formatted citation
Spandidos Publications style
Campos MD, Vieira WD, Campos CN, Aarestrup FM and Aarestrup BJ: Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats. Mol Clin Oncol 3: 825-828, 2015.
APA
Campos, M.D., Vieira, W.D., Campos, C.N., Aarestrup, F.M., & Aarestrup, B.J. (2015). Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats. Molecular and Clinical Oncology, 3, 825-828. https://doi.org/10.3892/mco.2015.544
MLA
Campos, M. D., Vieira, W. D., Campos, C. N., Aarestrup, F. M., Aarestrup, B. J."Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats". Molecular and Clinical Oncology 3.4 (2015): 825-828.
Chicago
Campos, M. D., Vieira, W. D., Campos, C. N., Aarestrup, F. M., Aarestrup, B. J."Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats". Molecular and Clinical Oncology 3, no. 4 (2015): 825-828. https://doi.org/10.3892/mco.2015.544
Copy and paste a formatted citation
x
Spandidos Publications style
Campos MD, Vieira WD, Campos CN, Aarestrup FM and Aarestrup BJ: Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats. Mol Clin Oncol 3: 825-828, 2015.
APA
Campos, M.D., Vieira, W.D., Campos, C.N., Aarestrup, F.M., & Aarestrup, B.J. (2015). Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats. Molecular and Clinical Oncology, 3, 825-828. https://doi.org/10.3892/mco.2015.544
MLA
Campos, M. D., Vieira, W. D., Campos, C. N., Aarestrup, F. M., Aarestrup, B. J."Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats". Molecular and Clinical Oncology 3.4 (2015): 825-828.
Chicago
Campos, M. D., Vieira, W. D., Campos, C. N., Aarestrup, F. M., Aarestrup, B. J."Atorvastatin and trans‑caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats". Molecular and Clinical Oncology 3, no. 4 (2015): 825-828. https://doi.org/10.3892/mco.2015.544
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