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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Article

Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis

  • Authors:
    • Cheng Fang
    • Hui Zeng
    • Anling Li
    • Xianqun Xu
    • Xinghua Long
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 892-896
    |
    Published online on: April 17, 2015
       https://doi.org/10.3892/mco.2015.547
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Abstract

Recently, several studies regarding the association between the pri‑miR‑124‑1 rs531564 polymorphism and cancer susceptibility were explored. Owing to inconsistent results of these studies, a meta‑analysis was conducted to determine the association of this polymorphism with cancer risk. Relevant studies were identified by a systematic search of PubMed, EMBASE, Web of Science and CNKI on‑line databases. Odds ratios (ORs) and 95% confidence intervals (CIs) from eligible studies were pooled, and heterogeneity and publication bias were also evaluated. A total of five studies with 2,253 cases and 2,510 controls were included in the meta‑analysis. Overall, the results showed that the pri‑miR‑124‑1 rs531564 polymorphism was significantly associated with a reduced cancer risk (G vs. C: OR, 0.86; 95% CI, 0.77‑0.96; GG vs. CC: OR, 0.52; 95% CI, 0.34‑0.79; GG vs. CG/CC: OR, 0.54; 95% CI, 0.36‑0.81). Furthermore, in the subgroup analysis by cancer sites, a statistical association was identified between the rs531564 polymorphism and a decreased esophageal squamous cell carcinoma (ESCC) risk (G vs. C: OR, 0.87; 95% CI, 0.77‑0.98; GG vs. CC: OR, 0.54; 95% CI, 0.34‑0.84). These findings suggested that the genetic variant of rs531564 may have a potential value in decreasing cancer risk, particularly in ESCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Fang C, Zeng H, Li A, Xu X and Long X: Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis. Mol Clin Oncol 3: 892-896, 2015.
APA
Fang, C., Zeng, H., Li, A., Xu, X., & Long, X. (2015). Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis. Molecular and Clinical Oncology, 3, 892-896. https://doi.org/10.3892/mco.2015.547
MLA
Fang, C., Zeng, H., Li, A., Xu, X., Long, X."Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis". Molecular and Clinical Oncology 3.4 (2015): 892-896.
Chicago
Fang, C., Zeng, H., Li, A., Xu, X., Long, X."Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis". Molecular and Clinical Oncology 3, no. 4 (2015): 892-896. https://doi.org/10.3892/mco.2015.547
Copy and paste a formatted citation
x
Spandidos Publications style
Fang C, Zeng H, Li A, Xu X and Long X: Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis. Mol Clin Oncol 3: 892-896, 2015.
APA
Fang, C., Zeng, H., Li, A., Xu, X., & Long, X. (2015). Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis. Molecular and Clinical Oncology, 3, 892-896. https://doi.org/10.3892/mco.2015.547
MLA
Fang, C., Zeng, H., Li, A., Xu, X., Long, X."Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis". Molecular and Clinical Oncology 3.4 (2015): 892-896.
Chicago
Fang, C., Zeng, H., Li, A., Xu, X., Long, X."Association of the pri‑miR‑124‑1 rs531564 polymorphism with cancer risk: A meta‑analysis". Molecular and Clinical Oncology 3, no. 4 (2015): 892-896. https://doi.org/10.3892/mco.2015.547
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