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Article

Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis

  • Authors:
    • Shi‑Ji Xiao
    • Jian‑Zhen Shen
    • Jin‑Long Huang
    • Hai-Ying Fu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China
  • Pages: 880-888
    |
    Published online on: May 11, 2015
       https://doi.org/10.3892/mco.2015.562
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Abstract

Numerous studies have investigated the prognostic role of brain and acute leukemia, cytoplasmic (BAALC) gene expression in adult patients with acute myeloid leukemia (AML); however, the results are inconclusive. A meta‑analysis was conducted to provide a comprehensive evaluation of the prognostic role of BAALC gene expression in AML. Eligible studies were searched through PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure and the China Biology Medicine Disc. Correlations between the BAALC gene expression and clinicopathological features and prognosis were analyzed. A total of 15 studies were examined. The pooled results suggest that high BAALC expression had an unfavorable outcome in AML. The combined hazard ratio (HR) for overall survival (OS) was 1.53 and the summary HR for the disease‑free survival rate was 1.64. In addition, subgroup analyses considering cytogenetic and survival analysis were also conducted. High BAALC gene expression appeared to be an adverse prognostic indicator in patients with cytogenetically normal AML (HR for OS, 1.43) and in subgroups of survival analysis with multivariate analysis (HR for OS, 2.35). These results indicate that high BAALC gene expression served as an independent poor prognostic indicator in adult patients with AML.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao SJ, Shen JZ, Huang JL and Fu H: Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis. Mol Clin Oncol 3: 880-888, 2015.
APA
Xiao, S., Shen, J., Huang, J., & Fu, H. (2015). Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis. Molecular and Clinical Oncology, 3, 880-888. https://doi.org/10.3892/mco.2015.562
MLA
Xiao, S., Shen, J., Huang, J., Fu, H."Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 3.4 (2015): 880-888.
Chicago
Xiao, S., Shen, J., Huang, J., Fu, H."Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 3, no. 4 (2015): 880-888. https://doi.org/10.3892/mco.2015.562
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao SJ, Shen JZ, Huang JL and Fu H: Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis. Mol Clin Oncol 3: 880-888, 2015.
APA
Xiao, S., Shen, J., Huang, J., & Fu, H. (2015). Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis. Molecular and Clinical Oncology, 3, 880-888. https://doi.org/10.3892/mco.2015.562
MLA
Xiao, S., Shen, J., Huang, J., Fu, H."Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 3.4 (2015): 880-888.
Chicago
Xiao, S., Shen, J., Huang, J., Fu, H."Prognostic significance of the BAALC gene expression in adult patients with acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 3, no. 4 (2015): 880-888. https://doi.org/10.3892/mco.2015.562
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