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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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July-2015 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China

  • Authors:
    • Ablajan Abdurahman
    • Jurat Anwar
    • Abdugheni Turghun
    • Madiniyet Niyaz
    • Liwei Zhang
    • Idiris Awut
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Clinical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
  • Pages: 847-850
    |
    Published online on: May 11, 2015
       https://doi.org/10.3892/mco.2015.564
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Abstract

This study was conducted to investigate the mutation status of epidermal growth factor receptor (EGFR) and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer (NSCLC) patients from the Xinjiang Uygur Autonomous Region in China. We enrolled 51 cases of NSCLC patients who received radical surgical treatment in the First Affiliated Hospital of Xinjiang Medical University. Quantitative polymerase chain reaction was applied to detect exons 18, 19, 20 and 21 of the EGFR gene in tumor tissues. Multiple tumor markers, including carcinoembryonic antigen (CEA), were assessed preoperatively. The EGFR‑positive rate was 49.02% (25/51), with a mutation rate of 8% (2/25) in exon 18, 52% (13/51) in exon 19, 40% (10/51) in exon 21 and no mutations in exon 20. The positive mutation rate in men and women was 37.5% (12/32) and 68.42%, respectively (13/19), with a statistically significantly higher rate in women (P<0.05). There were also statistically significant differences among adenocarcinoma, adenosquamous carcinoma and squamous cell carcinoma cases (P<0.05), while no statistically significant differences were observed in adenocarcinoma cases regarding degree of differentiation, lymph node metastasis and TNM stage (P>0.05). There was a statistically significant association between the EGFR gene mutation status and the preoperative serum CEA level (P<0.05). The mutation rate of the EGFR gene was 68.42% in female lung adenocarcinoma patients, which supports the application of targeted therapy in such cases. However, whether it is possible to obtain information regarding targeted therapy through measuring the level of serum CEA for NSCLC patients with unknown EGFR mutation status requires further investigation through related studies including a higher number of cases.
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Copy and paste a formatted citation
Spandidos Publications style
Abdurahman A, Anwar J, Turghun A, Niyaz M, Zhang L and Awut I: Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China. Mol Clin Oncol 3: 847-850, 2015.
APA
Abdurahman, A., Anwar, J., Turghun, A., Niyaz, M., Zhang, L., & Awut, I. (2015). Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China. Molecular and Clinical Oncology, 3, 847-850. https://doi.org/10.3892/mco.2015.564
MLA
Abdurahman, A., Anwar, J., Turghun, A., Niyaz, M., Zhang, L., Awut, I."Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China". Molecular and Clinical Oncology 3.4 (2015): 847-850.
Chicago
Abdurahman, A., Anwar, J., Turghun, A., Niyaz, M., Zhang, L., Awut, I."Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China". Molecular and Clinical Oncology 3, no. 4 (2015): 847-850. https://doi.org/10.3892/mco.2015.564
Copy and paste a formatted citation
x
Spandidos Publications style
Abdurahman A, Anwar J, Turghun A, Niyaz M, Zhang L and Awut I: Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China. Mol Clin Oncol 3: 847-850, 2015.
APA
Abdurahman, A., Anwar, J., Turghun, A., Niyaz, M., Zhang, L., & Awut, I. (2015). Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China. Molecular and Clinical Oncology, 3, 847-850. https://doi.org/10.3892/mco.2015.564
MLA
Abdurahman, A., Anwar, J., Turghun, A., Niyaz, M., Zhang, L., Awut, I."Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China". Molecular and Clinical Oncology 3.4 (2015): 847-850.
Chicago
Abdurahman, A., Anwar, J., Turghun, A., Niyaz, M., Zhang, L., Awut, I."Epidermal growth factor receptor gene mutation status and its association with clinical characteristics and tumor markers in non‑small‑cell lung cancer patients in Northwest China". Molecular and Clinical Oncology 3, no. 4 (2015): 847-850. https://doi.org/10.3892/mco.2015.564
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