Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2015 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2015 Volume 3 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size

  • Authors:
    • Zhang Yuan
    • Jiang Quan
    • Zhang Yunxiao
    • Chen Jian
    • He Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Shanghai Pudong New Area People's Hospital, Pudong New Area, Shanghai 200001, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 743-746
    |
    Published online on: May 15, 2015
       https://doi.org/10.3892/mco.2015.570
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to discuss the various appearances of thyroid carcinomas on real-time contrast-enhanced ultrasound (CEUS) in association with tumor size. The appearances of 68 thyroid carcinomas confirmed by pathology were retrospectively analyzed. The lesions were divided into 3 groups by maximum diameter <10, 10‑20 and >20 mm, respectively. For each lesion, absolute enhancement beginning time, relative enhancement beginning time, homogeneity, with or without perfusion defect, enhancement order, enhancement intensity and enhancement margin type were evaluated by CEUS. The majority of thyroid carcinomas were enhanced later than the surrounding thyroid gland. The predominant enhancement pattern of all the 68 thyroid carcinomas in the 3 groups was mainly heterogeneous and concentric enhancement, and the lesions mostly showed less clear or poorly defined enhancement margins. There was no significant difference among the 3 groups (P>0.05). Thyroid carcinoma with diameters <10 and 10‑20 mm exhibited low enhancement, while thyroid carcinomas with diameters >20 mm showed high enhancement. With the increase of the lesion's maximum diameter, the probability of perfusion defect increased by 28.57, 54.29 and 75.00%, respectively, and there was a significant difference among the 3 groups (P<0.05). CEUS characteristics are associated with tumor size to a certain extent, and can provide valuable information for clinical diagnosis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Mortensen JD, Woolner LB and Bennett WA: Gross and microscopic findings in clinically normal thyroid glands. J Clin Endocrinol Metab. 15:1270–1280. 1995. View Article : Google Scholar

2 

Gharib H, Papini E, Paschke R, Duick DS, Valcavi R, Hegedüs L and Vitti P: American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive summary of recommendations. J Endocrinol Invest. 33:51–56. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Hegedus L: Clinical practice. The thyroid nodule. N Engl J Med. 351:1764–1771. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI and Tessler FN: Management of thyroid nodules detected at US: Society of radiologists in ultrasound consensus conference statement. Radiology. 237:794–800. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Bartolotta TV, Midiri M, Galia M, Runza G, Attard M, Savoia G, Lagalla R and Cardinale AE: Qualitative and quantitative evaluation of solitary thyroid nodules with contrast-enhanced ultrasound: initial results. Eur Radiol. 16:2234–2241. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Nemec U, Nemec SF, Novotny C, Weber M, Czerny C and Krestan CR: Quantitative evaluation of contrast-enhanced ultrasound after intravenous administration of a microbubble contrast agent for differentiation of benign and malignant thyroid nodules: assessment of diagnostic accuracy. Eur Radiol. 22:1357–1365. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Hornung M, Jung EM, Georgieva M, Schlitt HJ, Stroszczynski C and Agha A: Detection of microvascularization of thyroid carcinomas using linear high resolution contrast-enhanced ultrasonography (CEUS). Clin Hemorheol Microcirc. 52:197–203. 2012.PubMed/NCBI

8 

Zhang B, Jiang YX, Liu JB, Yang M, Dai Q, Zhu QL and Gao P: Utility of contrast-enhanced ultrasound for evaluation of thyroid nodules. Thyroid. 20:51–57. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Friedrich-Rust M, Sperber A, Holzer K, Diener J, Grünwald F, Badenhoop K, Weber S, Kriener S, Herrmann E, Bechstein WO, Zeuzem S and Bojunga J: Real-time elastography and contrast-enhanced ultrasound for the assessment of thyroid nodules. Exp Clin Endocrinol Diabetes. 118:602–609. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Xu HX: Contrast-enhanced ultrasound: The evolving applications. World J Radiol. 1:15–24. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Agha A, Hornung M, Rennert J, Uller W, Lighvani H, Schlitt HJ and Jung EM: Contrast-enhanced ultrasonography for localization of pathologic glands in patients with primary hyperparathyroidism. Surgery. 151:580–586. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Giusti M, Orlandi D, Melle G, Massa B, Silvestri E, Minuto F and Turtulici G: Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules? J Zhejiang Univ Sci B. 14:195–206. 2013.(In Chinese). View Article : Google Scholar : PubMed/NCBI

13 

Zheng XJ, Zhang YK, Zhao CY, Liang JR, LE HB, Jiang JF, Wang H, Zou SD and Chen YF: Enhancement pattern of thyroid carcinoma with contrast-enhanced ultrasound. Zhonghua YiXue Za Zhi. 90:42–45. 2010.(In Chinese).

14 

Averkious M, Powers J, Skyba D, Bruce M and Jensen S: Ultrasound contrast imaging research. ultrasound Q. 19:27–37. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Jain RK: Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med. 7:987–989. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yuan Z, Quan J, Yunxiao Z, Jian C and Zhu H: Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size. Mol Clin Oncol 3: 743-746, 2015.
APA
Yuan, Z., Quan, J., Yunxiao, Z., Jian, C., & Zhu, H. (2015). Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size. Molecular and Clinical Oncology, 3, 743-746. https://doi.org/10.3892/mco.2015.570
MLA
Yuan, Z., Quan, J., Yunxiao, Z., Jian, C., Zhu, H."Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size". Molecular and Clinical Oncology 3.4 (2015): 743-746.
Chicago
Yuan, Z., Quan, J., Yunxiao, Z., Jian, C., Zhu, H."Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size". Molecular and Clinical Oncology 3, no. 4 (2015): 743-746. https://doi.org/10.3892/mco.2015.570
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan Z, Quan J, Yunxiao Z, Jian C and Zhu H: Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size. Mol Clin Oncol 3: 743-746, 2015.
APA
Yuan, Z., Quan, J., Yunxiao, Z., Jian, C., & Zhu, H. (2015). Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size. Molecular and Clinical Oncology, 3, 743-746. https://doi.org/10.3892/mco.2015.570
MLA
Yuan, Z., Quan, J., Yunxiao, Z., Jian, C., Zhu, H."Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size". Molecular and Clinical Oncology 3.4 (2015): 743-746.
Chicago
Yuan, Z., Quan, J., Yunxiao, Z., Jian, C., Zhu, H."Association between real-time contrast-enhanced ultrasound characteristics and thyroid carcinoma size". Molecular and Clinical Oncology 3, no. 4 (2015): 743-746. https://doi.org/10.3892/mco.2015.570
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team