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Article

Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen

  • Authors:
    • Iheoma Y. Nwaogu
    • Oluwadamilola M. Fayanju
    • Donna B. Jeffe
    • Julie A. Margenthaler
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA, Division of General Medical Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA, The Alvin J. Siteman Cancer Center, Barnes‑Jewish Hospital, Washington University School of Medicine, St. Louis, MO 63110, USA
  • Pages: 1117-1122
    |
    Published online on: June 10, 2015
       https://doi.org/10.3892/mco.2015.579
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Abstract

In this study, we sought to determine the predictors of pathological complete response (pCR) and compare the chemotherapeutic regimens administered to breast cancer patients with and those without pCR. We retrospectively reviewed the data of 879 patients treated at the Alvin J. Siteman Cancer Center between 2006 and 2010, to identify patients who were diagnosed with primary stage II or III breast cancer and received neoadjuvant chemotherapy. Patients who received only neoadjuvant endocrine therapy were considered to be ineligible. Patient, tumor, and treatment characteristics, including type of chemotherapy, were compared between patients who did and those who did not achieve pCR using Chi‑square or Fisher's exact tests and multivariate logistic regression analysis. Two‑sided P‑values of <0.05 were considered significant. Of the 333 patients who met the inclusion criteria, 61 (18.3%) had documented pCR. Compared with patients not achieving pCR, a greater proportion of patients with pCR had stage II disease (80.3 vs. 68%, P=0.057), had poorly differentiated (grade 3) tumors (82 vs. 59.2%, P<0.001), had negative lymph node involvement (41 vs. 34%, P=0.0004) and had tumors that were HER2‑amplified (41 vs. 23.5%, P=0.0054). A greater proportion of patients with pCR received taxane‑based chemotherapy (23 vs. 12.5%, P=0.016) or trastuzumab in conjunction with chemotherapy (41.0 vs. 16.9%, P<0.001). No patients receiving solely anthracycline‑based therapy achieved pCR in our study. Our study demonstrated that, for stage II and III breast cancer, lower stage, negative lymph node involvement and HER2 receptor amplification were each associated with pCR. Taxane therapy and the concurrent use of trastuzumab were also associated with a higher likelihood of pCR.
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1 

Fisher B, Bryant J, Wolmark N, et al: Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol. 16:2672–2685. 1998.PubMed/NCBI

2 

Wolmark N, Wang J, Mamounas E, Bryant J and Fisher B: Preoperative chemotherapy in patients with operable breast cancer: Nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18. J Natl Cancer Inst Monogr. 30:96–102. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Van der Hage JA, van de Velde CJ, Julien JP, Tubiana-Hulin M, Vandervelden C and Duchateau L: Preoperative chemotherapy in primary operable breast cancer: Results from the European Organization for Research and Treatment of Cancer trial 10902. J Clin Oncol. 19:4224–4237. 2001.PubMed/NCBI

4 

Kong X, Moran MS, Zhang N, Haffty B and Yang Q: Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients. Eur J Cancer. 47:2084–2090. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Rastogi P, Anderson SJ, Bear HD, et al: Preoperative chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. J Clin Oncol. 26:778–785. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Di Cosimo S, Arpino G and Generali D: Neoadjuvant treatment of HER2 and hormone-receptor positive breast cancer - moving beyond pathological complete response. Breast. 23:188–192. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Hirano A, Shimizu T, Imamura H, et al: The combination of epirubicin plus docetaxel as neoadjuvant chemotherapy in locally-advanced breast cancer. Anticancer Res. 26:(1b). 581–584. 2006.PubMed/NCBI

8 

Gianni L, Eiermann W, Semiglazov V, et al: Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): Follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet Oncol. 15:640–647. 2014. View Article : Google Scholar : PubMed/NCBI

9 

McCarthy N, Boyle F, Zdenkowski N, et al: Australia and New Zealand Breast Cancer Trials Group: Neoadjuvant chemotherapy with sequential anthracycline-docetaxel with gemcitabine for large operable or locally advanced breast cancer: ANZ 0502 (NeoGem). Breast. 23:142–151. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Bear HD, Anderson S, Smith RE, et al: Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer: National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol. 24:2019–2027. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Mazouni C, Peintinger F, Wan-Kau S, et al: Residual ductal carcinoma in situ in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy does not adversely affect patient outcome. J Clin Oncol. 25:2650–2655. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Von Minckwitz G, Untch M, Blohmer JU, et al: Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol. 30:1796–1804. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Cataliotti L, Buzdar AU, Noguchi S, et al: Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor-positive breast cancer: The pre-operative ‘Arimidex’ compared to tamoxifen (PROACT) trial. Cancer. 106:2095–2103. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Semiglazov VF, Semiglazov VV, Dashyan GA, et al: Phase 2 randomized trial of primary endocrine therapy versus chemotherapy in postmenopausal patients with estrogen receptor-positive breast cancer. Cancer. 110:244–254. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Ellis MJ, Suman VJ, Hoog J, et al: Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: Clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype - ACOSOG Z1031. J Clin Oncol. 29:2342–2349. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Tan MC, Al Mushawah F, Gao F, et al: Predictors of complete pathological response after neoadjuvant systemic therapy for breast cancer. Am J Surg. 198:520–525. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Harari D and Yarden Y: Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene. 19:6102–6114. 2000. View Article : Google Scholar : PubMed/NCBI

18 

McCready DR, Hortobagyi GN, Kau SW, et al: The prognostic significance of lymph node metastases after preoperative chemotherapy for locally advanced breast cancer. Arch Surg. 124:21–25. 1989. View Article : Google Scholar : PubMed/NCBI

19 

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B and Senn HJ: Panel members: Strategies for subtypes - dealing with the diversity of breast cancer: Highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 22:1736–1747. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Petrelli F, Coinu A, Borgonovo K, Cabiddu M, Ghilardi M, Lonati V and Barni S: The value of platinum agents as neoadjuvant chemotherapy in triple-negative breast cancers: A systematic review and meta-analysis. Breast Cancer Res Treat. 144:223–232. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Silver DP, Richardson AL, Eklund AC, et al: Efficacy of neoadjuvant cisplatin in triple-negative breast cancer. J Clin Oncol. 28:1145–1153. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nwaogu IY, Fayanju OM, Jeffe DB and Margenthaler JA: Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen. Mol Clin Oncol 3: 1117-1122, 2015.
APA
Nwaogu, I.Y., Fayanju, O.M., Jeffe, D.B., & Margenthaler, J.A. (2015). Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen. Molecular and Clinical Oncology, 3, 1117-1122. https://doi.org/10.3892/mco.2015.579
MLA
Nwaogu, I. Y., Fayanju, O. M., Jeffe, D. B., Margenthaler, J. A."Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen". Molecular and Clinical Oncology 3.5 (2015): 1117-1122.
Chicago
Nwaogu, I. Y., Fayanju, O. M., Jeffe, D. B., Margenthaler, J. A."Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen". Molecular and Clinical Oncology 3, no. 5 (2015): 1117-1122. https://doi.org/10.3892/mco.2015.579
Copy and paste a formatted citation
x
Spandidos Publications style
Nwaogu IY, Fayanju OM, Jeffe DB and Margenthaler JA: Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen. Mol Clin Oncol 3: 1117-1122, 2015.
APA
Nwaogu, I.Y., Fayanju, O.M., Jeffe, D.B., & Margenthaler, J.A. (2015). Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen. Molecular and Clinical Oncology, 3, 1117-1122. https://doi.org/10.3892/mco.2015.579
MLA
Nwaogu, I. Y., Fayanju, O. M., Jeffe, D. B., Margenthaler, J. A."Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen". Molecular and Clinical Oncology 3.5 (2015): 1117-1122.
Chicago
Nwaogu, I. Y., Fayanju, O. M., Jeffe, D. B., Margenthaler, J. A."Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen". Molecular and Clinical Oncology 3, no. 5 (2015): 1117-1122. https://doi.org/10.3892/mco.2015.579
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