Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients

  • Authors:
    • Zhi Wang
    • Chengxue Dang
    • Kun Zhu
    • Yong Zhang
    • Dongmin Chang
    • Peng Xia
    • Yongchun Song
    • Kang Li
  • View Affiliations / Copyright

    Affiliations: Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710049, P.R. China, Department of Oncology Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 1088-1092
    |
    Published online on: June 24, 2015
       https://doi.org/10.3892/mco.2015.584
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The occurrence of chemotherapy-induced alterations in markers of haemostasis during chemotherapy has been reported previously. However, the change of the haemostasis markers in the cyclophosphamide, epirubicin and fluorouracil (CEF) regimen remains unclear. The aim of the present study was to identify the change of the haemostasis markers during systemic chemotherapy (600 mg/m2 cyclophosphamide, 80 mg/m2 epirubicin and 500 mg/m2 fluorouracil; four courses over 21 days) to investigate its influence on the haemostasis markers of breast cancer patients and to discuss the requirement of anticoagulation therapy. D‑dimer, activated partial thromboplastin time (APTT), prothrombin time (PT) and fibrinogen (FIB) values were obtained before chemotherapy and on days 1, 4, 7 and 21. The results show that PT, D‑dimer and FIB were not prolonged prior to chemotherapy compared to that under the control. APTT was prolonged until day 4. The levels of D‑dimer and APTT were significantly higher compared to those of the breast cancer patients before receiving chemotherapy and controls on days 1, 4, 7 and 21 after chemotherapy. Alteration of the haemostasis markers occurred in the breast cancer patients under the CEF chemotherapy regimen. As there is an increased risk of deep vein thrombosis and pool prognosis of cancer patients, anticoagulant therapy should be considered.
View Figures

Figure 1

Figure 2

View References

1 

Zecchina G, Ghio P, Bosio S, Cravino M, Camaschella C and Scagliotti GV: Reactive thrombocytosis might contribute to chemotherapy-related thrombophilia in patients with lung cancer. Clin Lung Cancer. 8:264–267. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Albertsson P, Lennernas B and Norrby K: Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. Acta Oncol. 48:418–425. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Milanini-Mongiat J, Pouyssegur J and Pages G: Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription. J Biol Chem. 277:20631–20639. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Karpatkin S: Does hypercoagulability awaken dormant tumor cells in the host? J Thromb Haemost. 2:2103–2106. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Sood SL: Cancer-associated thrombosis. Curr Opin Hematol. 16:378–385. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rak J, Yu JL, Luyendyk J and Mackman N: Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res. 66:10643–10646. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Sutherland DE, Weitz IC and Liebman HA: Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis, and treatment. Am J Hematol. 72:43–52. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Oberhoff C, Winkler UH, Hoffmann O and Schindler AE: Adjuvant CMF-chemotherapy and haemostasis. Effect of ‘classical’ and ‘modified’ adjuvant CMF-chemotherapy on blood coagulation fibrinolysis in patients with breast cancer. Eur J Gynaecol Oncol. 21:147–152. 2000.PubMed/NCBI

9 

Rella C, Coviello M, Giotta F, et al: A prothrombotic state in breast cancer patients treated with adjuvant chemotherapy. Breast Cancer Res Treat. 40:151–159. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Nomura H, Wada H, Mizuno T, et al: Elevated fibrin-related markers in patients with malignant diseases suspected of having thrombotic disorders. Clin Appl Thromb Hemost. 16:266–272. 2010. View Article : Google Scholar : PubMed/NCBI

11 

American Heart Association, . Classes of heart failure. http://www.heart.org/HEARTORG/Conditions/HeartFailure/AboutHeartFailure/Classes-of-Heat-Failure_UCM_306328_Article.jspSeptember 6–2011

12 

Baron JA, Gridley G, Weiderpass E, Nyren O and Linet M: Venous thromboembolism and cancer. Lancet. 351:1077–1080. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Garcia-Avello A, Galindo-Alvarez J, Martinez-Molina E, Cesar-Perez J and Navarro JL: Coagulative system activation and fibrinolytic system inhibition activities arise from tumoral draining vein in colon carcinoma. Thromb Res. 104:421–425. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Gabazza EC, Taguchi O, Yamakami T, et al: Alteration of coagulation and fibrinolysis systems after multidrug anticancer therapy for lung cancer. Eur J Cancer. 30A:1276–1281. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Siemens HJ, Gerke P, Steinhoff J, Roth-Isigkeit A, Wagner K and Bruckner S: A prolonged APTT in a patient with a low grade malignant NHL - a case report. Haematologica. 87:ELT082002.PubMed/NCBI

16 

Tamizifar B, Oghab P and Esfahani MA: The prediction role of D-dimer in recurrence of venous thromboembolism 1-year after anticoagulation discontinuing following idiopathic deep vein thrombosis. J Res Med Sci. 19:586–591. 2014.PubMed/NCBI

17 

Arpaia G, Carpenedo M, Verga M, et al: D-dimer before chemotherapy might predict venous thromboembolism. Blood Coagul Fibrinolysis. 20:170–175. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Gadducci A, Marrai R, Baicchi U, et al: Preoperative D-dimer plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer. Gynecol Oncol. 66:85–88. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Satoh T, Oki A, Uno K, et al: High incidence of silent venous thromboembolism before treatment in ovarian cancer. Br J Cancer. 97:1053–1057. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Lippi G, Franchini M, Biasiutti C, Dellagiacoma G, Salvagno GL and Guidi GC: Increased D-dimer value and occult cancer in the absence of detectable thrombosis. Haematologica. 92:e53–e55. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Oya M, Akiyama Y, Yanagida T, Akao S and Ishikawa H: Plasma D-dimer level in patients with colorectal cancer: its role as a tumor marker. Surg Today. 28:373–378. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Sawaguchi K, Yabushita H, Higuchi K, et al: Effect of remission induction chemotherapy on blood coagulability in patients with gynecological malignancies. Nippon Gan Chiryo Gakkai Shi. 24:798–808. 1989.(In Japanese). PubMed/NCBI

23 

Yigit E, Gonullu G, Yucel I, Turgut M, Erdem D and Cakar B: Relation between hemostatic parameters and prognostic/predictive factors in breast cancer. Eur J Intern Med. 19:602–607. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Batschauer AP, Figueiredo CP, Bueno EC, et al: D-dimer as a possible prognostic marker of operable hormone receptor-negative breast cancer. Ann Oncol. 21:1267–1272. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Lyman GH: Thromboprophylaxis with low-molecular-weight heparin in medical patients with cancer. Cancer. 115:5637–5650. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Di Nisio M, Klerk CP, Meijers JC and Büller HR: The prognostic value of the D-dimer test in cancer patients treated with and without low-molecular-weight heparin. J Thromb Haemost. 3:1531–1533. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Sousou T and Khorana AA: New insights into cancer-associated thrombosis. Arterioscler Thromb Vasc Biol. 29:316–320. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Gerotziafas GT, Papageorgiou C, Hatmi M, Samama MM and Elalamy I: Clinical studies with anticoagulants to improve survival in cancer patients. Pathophysiol Haemost Thromb. 36:204–211. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Dang C, Zhu K, Zhang Y, Chang D, Xia P, Song Y and Li K: Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients. Mol Clin Oncol 3: 1088-1092, 2015.
APA
Wang, Z., Dang, C., Zhu, K., Zhang, Y., Chang, D., Xia, P. ... Li, K. (2015). Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients. Molecular and Clinical Oncology, 3, 1088-1092. https://doi.org/10.3892/mco.2015.584
MLA
Wang, Z., Dang, C., Zhu, K., Zhang, Y., Chang, D., Xia, P., Song, Y., Li, K."Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients". Molecular and Clinical Oncology 3.5 (2015): 1088-1092.
Chicago
Wang, Z., Dang, C., Zhu, K., Zhang, Y., Chang, D., Xia, P., Song, Y., Li, K."Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients". Molecular and Clinical Oncology 3, no. 5 (2015): 1088-1092. https://doi.org/10.3892/mco.2015.584
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Dang C, Zhu K, Zhang Y, Chang D, Xia P, Song Y and Li K: Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients. Mol Clin Oncol 3: 1088-1092, 2015.
APA
Wang, Z., Dang, C., Zhu, K., Zhang, Y., Chang, D., Xia, P. ... Li, K. (2015). Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients. Molecular and Clinical Oncology, 3, 1088-1092. https://doi.org/10.3892/mco.2015.584
MLA
Wang, Z., Dang, C., Zhu, K., Zhang, Y., Chang, D., Xia, P., Song, Y., Li, K."Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients". Molecular and Clinical Oncology 3.5 (2015): 1088-1092.
Chicago
Wang, Z., Dang, C., Zhu, K., Zhang, Y., Chang, D., Xia, P., Song, Y., Li, K."Cyclophosphamide, epirubicin and fluorouracil chemotherapy-induced alteration of haemostasis markers in breast cancer patients". Molecular and Clinical Oncology 3, no. 5 (2015): 1088-1092. https://doi.org/10.3892/mco.2015.584
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team