Short-term outcomes between laparoscopy-assisted and open colorectomy for colorectal cancer in elderly patients: A case-matched control study

Chen,Zexian; He,Xiaosheng; Huang,Juanni; Zeng,Yike; Lian,Lei; Wu,Xiaojian; Lei,Jian; Wang,Jianping; Lan,Ping

doi:10.3892/mco.2015.585

September-2015 Volume 3 Issue 5

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September-2015 Volume 3 Issue 5

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Article

Short-term outcomes between laparoscopy-assisted and open colorectomy for colorectal cancer in elderly patients: A case-matched control study

Authors:
- Zexian Chen
- Xiaosheng He
- Juanni Huang
- Yike Zeng
- Lei Lian
- Xiaojian Wu
- Jian Lei
- Jianping Wang
- Ping Lan
View Affiliations / Copyright

Affiliations: Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510655, P.R. China, Department of Geriatrics, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510655, P.R. China, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510655, P.R. China
Pages: 1155-1159
|
Published online on: June 24, 2015

https://doi.org/10.3892/mco.2015.585
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Abstract

With the increase in life expectancy, surgical intervention for colorectal cancer (CRC) is more frequently performed in elderly patients. This retrospective study was designed to compare short‑term outcomes between laparoscopy‑assisted colorectomy (LC) and open colorectomy (OC) in elderly patients with CRC. A total of 89 CRC patients aged ≥75 years undergoing LC were matched with 89 counterparts undergoing OC. The matching criteria included general information and preoperative status. The operative data and short‑term postoperative outcomes were compared. Following analysis, patients in the LC and OC groups were comparable for the matching criteria. Compared with the OC group, the operative time was longer (P=0.046), but the estimated blood loss (P<0.001) and intraoperative transfusion (P=0.042) were less in the LC group. As regards short‑term postoperative outcomes, the duration of postoperative hospital stay was shorter (P=0.001) and the incidence of wound complications was lower (P=0.044) with LC. The overall complication, other complications, reoperation and mortality rates were comparable between the two groups. In conclusion, considering the operative variables and short‑term outcomes, LC is a safe procedure and appears to be superior to OC for elderly patients with CRC.

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1	Levi F, Lucchini F, Negri E, Boyle P and La Vecchia C: Changed trends of cancer mortality in the elderly. Ann Oncol. 12:1467–1477. 2001. View Article : Google Scholar : PubMed/NCBI
2	Folprecht G, Cunningham D, Ross P, et al: Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol. 15:1330–1338. 2004. View Article : Google Scholar : PubMed/NCBI
3	Tan KY, Konishi F, Kawamura YJ, et al: Laparoscopic colorectal surgery in elderly patients: a case-control study of 15 years of experience. Am J Surg. 201:531–536. 2011. View Article : Google Scholar : PubMed/NCBI
4	Sylla P, Kirman I and Whelan RL: Immunological advantages of advanced laparoscopy. Surg Clin North Am. 85:1–18. 2005. View Article : Google Scholar : PubMed/NCBI
5	Kang CY, Chaudhry OO, Halabi WJ, et al: Outcomes of laparoscopic colorectal surgery: data from the Nationwide Inpatient Sample 2009. Am J Surg. 204:952–957. 2012. View Article : Google Scholar : PubMed/NCBI
6	Orcutt ST, Marshall CL, Robinson CN, et al: Minimally invasive surgery in colon cancer patients leads to improved short-term outcomes and excellent oncologic results. Am J Surg. 202:528–531. 2011. View Article : Google Scholar : PubMed/NCBI
7	Abraham NS, Young JM and Solomon MJ: Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer. Br J Surg. 91:1111–1124. 2004. View Article : Google Scholar : PubMed/NCBI
8	Frasson M, Braga M, Vignali A, Zuliani W and Di Carlo V: Benefits of laparoscopic colorectal resection are more pronounced in elderly patients. Dis Colon Rectum. 51:296–300. 2008. View Article : Google Scholar : PubMed/NCBI
9	Lian L, Kalady M, Geisler D and Kiran RP: Laparoscopic colectomy is safe and leads to a significantly shorter hospital stay for octogenarians. Surg Endosc. 24:2039–2043. 2010. View Article : Google Scholar : PubMed/NCBI
10	Pinto RA, Ruiz D, Edden Y, Weiss EG, Nogueras JJ and Wexner SD: How reliable is laparoscopic colorectal surgery compared with laparotomy for octogenarians? Surg Endosc. 25:2692–2698. 2011. View Article : Google Scholar : PubMed/NCBI
11	Fernandes R, Shaikh I and Doughan S: Outcomes of elective laparoscopic colorectal operations in octogenarians at a district general hospital in S outh E ast England. World J Gastrointest Surg. 5:9–11. 2013. View Article : Google Scholar : PubMed/NCBI
12	Issa N, Grassi C, Melki Y, Powsner E and Dreznik Z: Laparoscopic colectomy for carcinoma of the colon in octogenarians. J Gastrointest Surg. 15:2011–2015. 2011. View Article : Google Scholar : PubMed/NCBI
13	Yang G, Wang Y, Zeng Y, et al: Rapid health transition in China, 1990–2010: findings from the G lobal Burden of D isease S tudy 2010. Lancet. 381:1987–2015. 2013. View Article : Google Scholar : PubMed/NCBI
14	Senagore AJ, Madbouly KM, Fazio VW, Duepree HJ, Brady KM and Delaney CP: Advantages of laparoscopic colectomy in older patients. Arch Surg. 138:252–256. 2003. View Article : Google Scholar : PubMed/NCBI
15	Feng B, Zheng MH, Mao ZH, et al: Clinical advantages of laparoscopic colorectal cancer surgery in the elderly. Aging Clin Exp Res. 18:191–195. 2006. View Article : Google Scholar : PubMed/NCBI
16	Vignali A, Di Palo S, Tamburini A, Radaelli G, Orsenigo E and Staudacher C: Laparoscopic vs. open colectomies in octogenarians: a case-matched control study. Dis Colon Rectum. 48:2070–2075. 2005. View Article : Google Scholar : PubMed/NCBI
17	Delgado S, Lacy AM, García Valdecasas JC, et al: Could age be an indication for laparoscopic colectomy in colorectal cancer? Surg Endosc. 14:22–26. 2000. View Article : Google Scholar : PubMed/NCBI
18	Kapritsou M, Korkolis DP and Konstantinou EA: Open or laparoscopic surgery for colorectal cancer: a retrospective comparative study. Gastroenterol Nurs. 36:37–41. 2013. View Article : Google Scholar : PubMed/NCBI
19	Stewart BT, Stitz RW and Lumley JW: Laparoscopically assisted colorectal surgery in the elderly. Br J Surg. 86:938–941. 1999. View Article : Google Scholar : PubMed/NCBI
20	Kuhry E, Schwenk WF, Gaupset R, Romild U and Bonjer HJ: Long-term results of laparoscopic colorectal cancer resection. Cochrane Database Syst Rev. 16:CD0034322008.
21	Ohtani H, Tamamori Y, Arimoto Y, Nishiguchi Y, Maeda K and Hirakawa K: A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and open colectomy for colon cancer. J Cancer. 3:49–57. 2012. View Article : Google Scholar : PubMed/NCBI
22	Di B, Li Y, Wei K, et al: Laparoscopic versus open surgery for colon cancer: A meta-analysis of 5-year follow-up outcomes. Surg Oncol. 22:e39–e43. 2013. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Short-term outcomes between laparoscopy-assisted and open colorectomy for colorectal cancer in elderly patients: A case-matched control study

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