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Article

Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy

  • Authors:
    • Xiangcun Liang
    • Huiming Yu
    • Rong Yu
    • Gang Xu
    • Guangying Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Hebei Provincial Chest Hospital, Shijiazhuang, Hebei 050041, P.R. China, Department of Radiation Oncology, Peking University Cancer Hospital, Beijing 100142, P.R. China
  • Pages: 1172-1176
    |
    Published online on: June 25, 2015
       https://doi.org/10.3892/mco.2015.588
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Abstract

The present study reports the local recurrence, distant metastasis, progression‑free survival, overall survival and radiation toxicity between two arms of stage III non‑small cell lung cancer (NSCLC) treated with intensity‑modulated radiotherapy (IMRT); one arm with clinical target volume (CTV) and the other without CTV. The two arms of local recurrence, distant metastasis, progression‑free survival, overall survival, grade 3‑4 radiation esophagitis and hematological toxicity had no statistical significance. However, the grade 3‑4 radiation pneumonia rate of the group without CTV was significantly decreased. This supports the concept that stage III NSCLC treated with IMRT, which omitted CTV, can reduce the occurrence of radiation pneumonia. The aim of the present study was to analyze the feasibility of the smaller target volume for stage III NSCLC treated with IMRT. Data from 105 patients with stage III NSCLC who were hospitalized and received IMRT between January 1, 2008 and November 30, 2012 were retrospectively analyzed. A total of 55 cases were irradiated with target volume without CTV and 50 cases were irradiated with CTV. Dose prescription was 100% PTV at 54‑63 Gy/27‑35 F/5.4‑7 weeks. The two arms of the patient characteristics and treatment deliveries had no statistical significance. The two arms of the patients were compared for local recurrence, distant metastasis, progression‑free survival, overall survival and radiation‑related toxicity. In the arms without and with CTV, the local relapse and distant metastases rates were 32.7 and 32.0% (P=1.000) and 56.4 and 48.0% (P=0.946), respectively. The median progression‑free survival time for the two arms was 9 months (P=0.619). The 1‑, 2‑ and 3‑year survival rates of the arms without and with CTV were 74.5, 43.6 and 23.6%, and 70.0, 46.0 and 20.0% (P=0.956), respectively. In the two arms, grade 3‑4 radiation esophagitis and hematological toxicity had no statistical significance. However, in the arm without CTV, grade 3‑4 radiation pneumonia was only 5.5%, compared with 18.0% in the arm with CTV (P=0.044). In conclusion, the smaller target volume for stage III NSCLC treated with IMRT was feasible.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. J Clin. 63:11–30. 2013. View Article : Google Scholar

2 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Sant M, Aareleid T, Berrino F, Bielska Lasota M, Carli PM, Faivre J, Grosclaude P, Hédelin G, Matsuda T, Møller H, et al: EUROCARE Working Group: EUROCARE-3: Survival of cancer patients diagnosed 1990–94 - results and commentary. Ann Oncol 14. (Suppl 5). v61–v118. 2003. View Article : Google Scholar

5 

Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN, Medhora MM and Li XA: Irradiation of varying volumes of rat lung to same mean lung dose: A little to a lot or a lot to a little? Int J Radiat Oncol Biol Phys. 71:838–847. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Yorke ED, Jackson A, Rosenzweig KE, Merrick SA, Gabrys D, Venkatraman ES, Burman CM, Leibel SA and Ling CC: Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys. 54:329–339. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Kong FM, Hayman JA, Griffith KA, Kalemkerian GP, Arenberg D, Lyons S, Turrisi A, Lichter A, Fraass B, Eisbruch A, et al: Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys. 65:1075–1086. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Marks LB, Bentzen SM, Deasy JO, Kong FM, Bradley JD, Vogelius IS, El Naqa I, Hubbs JL, Lebesque JV, Timmerman RD, et al: Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys. 76:(Sul). S70–S76. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Giraud P, Antoine M, Larrouy A, Milleron B, Callard P, De Rycke Y, Carette MF, Rosenwald JC, Cosset JM, Housset M, et al: Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning. Int J Radiat Oncol Biol Phys. 48:1015–1024. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Cai S, Shi A, Yu R and Zhu G: Feasibility of omitting clinical target volume for limited-disease small cell lung cancer treated with chemotherapy and intensity-modulated radiotherapy. Radiat Oncol. 9:172014. View Article : Google Scholar : PubMed/NCBI

11 

Parashar B, Edwards A, Mehta R, Pasmantier M, Wernicke AG, Sabbas A, Kerestez RS, Nori D and Chao KS: Chemotherapy significantly increases the risk of radiation pneumonitis in radiation therapy of advanced lung cancer. Am J Clin Oncol. 34:160–164. 2011.PubMed/NCBI

12 

Sura S, Gupta V, Yorke E, Jackson A, Amols H and Rosenzweig KE: Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience. Radiother Oncol. 87:17–23. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Karar J and Maity A: Modulating the tumor microenvironment to increase radiation responsiveness. Cancer Biol Ther. 8:1994–2001. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Rengan R, Rosenzweig KE, Venkatraman E, Koutcher LA, Fox JL, Nayak R, Amols H, Yorke E, Jackson A, Ling CC, et al: Improved local control with higher doses of radiation in large-volume stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 60:741–747. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Bradley JD, Ieumwananonthachai N, Purdy JA, Wasserman TH, Lockett MA, Graham MV and Perez CA: Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys. 52:49–57. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Werner-Wasik M, Scott C, Cox JD, Sause WT, Byhardt RW, Asbell S, Russell A, Komaki R and Lee JS: Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): Identification of five groups with different survival. Int J Radiat Oncol Biol Phys. 48:1475–1482. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Littbrand B and Révész L: The effect of oxygen on cellular survival and recovery after radiation. Br J Radiol. 42:914–924. 1969. View Article : Google Scholar : PubMed/NCBI

18 

Zhao L, Chen M, Ten Haken R, Chetty I, Chapet O, Hayman JA and Kong FM: Three-dimensional conformal radiation may deliver considerable dose of incidental nodal irradiation in patients with early stage node-negative non-small cell lung cancer when the tumor is large and centrally located. Radiother Oncol. 82:153–159. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Arriagada R, Le Chevalier T, Quoix E, Ruffie P, de Cremoux H, Douillard JY, Tarayre M, Pignon JP and Laplanche A: ASTRO (American Society for Therapeutic Radiology and Oncology) plenary: Effect of chemotherapy on locally advanced non-small cell lung carcinoma: a randomized study of 353 patients. GETCB (Groupe d'Etude et Traitement des Cancers Bronchiques), FNCLCC (Féderation Nationale des Centres de Lutte contre le Cancer) and the CEBI trialists. Int J Radiat Oncol Biol Phys. 20:1183–1190. 1991. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liang X, Yu H, Yu R, Xu G and Zhu G: Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy. Mol Clin Oncol 3: 1172-1176, 2015.
APA
Liang, X., Yu, H., Yu, R., Xu, G., & Zhu, G. (2015). Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy. Molecular and Clinical Oncology, 3, 1172-1176. https://doi.org/10.3892/mco.2015.588
MLA
Liang, X., Yu, H., Yu, R., Xu, G., Zhu, G."Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy". Molecular and Clinical Oncology 3.5 (2015): 1172-1176.
Chicago
Liang, X., Yu, H., Yu, R., Xu, G., Zhu, G."Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy". Molecular and Clinical Oncology 3, no. 5 (2015): 1172-1176. https://doi.org/10.3892/mco.2015.588
Copy and paste a formatted citation
x
Spandidos Publications style
Liang X, Yu H, Yu R, Xu G and Zhu G: Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy. Mol Clin Oncol 3: 1172-1176, 2015.
APA
Liang, X., Yu, H., Yu, R., Xu, G., & Zhu, G. (2015). Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy. Molecular and Clinical Oncology, 3, 1172-1176. https://doi.org/10.3892/mco.2015.588
MLA
Liang, X., Yu, H., Yu, R., Xu, G., Zhu, G."Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy". Molecular and Clinical Oncology 3.5 (2015): 1172-1176.
Chicago
Liang, X., Yu, H., Yu, R., Xu, G., Zhu, G."Efficacy of the smaller target volume for stage III non-small cell lung cancer treated with intensity-modulated radiotherapy". Molecular and Clinical Oncology 3, no. 5 (2015): 1172-1176. https://doi.org/10.3892/mco.2015.588
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