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Article

Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer

  • Authors:
    • Ilhan Hacibekiroglu
    • Hilmi Kodaz
    • Bulent Erdogan
    • Esma Turkmen
    • Asim Esenkaya
    • Yilmaz Onal
    • Sernaz Uzunoglu
    • Irfan Cicin
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey, Department of Radiology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey, Department of Internal Medicine, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
  • Pages: 1160-1164
    |
    Published online on: July 1, 2015
       https://doi.org/10.3892/mco.2015.592
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Abstract

The aim of this study was to retrospectively compare the efficacy and toxicity of the oxaliplatin + 5-fluorouracil (5‑FU) + leucovorin (LV) regimen [modified (m)FOLFOX-6] with that of the docetaxel + cisplatin + 5‑FU regimen (DCF) in patients with advanced gastric cancer (AGC). A total of 72 patients received DCF (75 mg/m2 docetaxel and 75 mg/m2 cisplatin on day 1 and 750 mg/m2 5-FU on days 1-5) every 21 days, whereas 54 patients received mFOLFOX-6 (85 mg/m2 oxaliplatin and 400 mg/m2 LV as a 2-h infusion, followed by a 5-FU bolus of 400 mg/m2 and 2,400 mg/m2 5-FU as a 46‑h continuous infusion) every 14 days. In the DCF arm, 55 (76.4%) of the patients received prophylactic granulocyte colony-stimulating factor (G-CSF), 48-72 h following completion of chemotherapy. The median follow-up of the study was 12.1 months. The overall response rate (ORR) was 37.0% for mFOLFOX-6 and 40.3% for DCF (p=0.72). The median time to progression was 6.5 and 6.2 months in the mFOLFOX-6 and DCF arms, respectively (p=0.70). The median overall survival was 11.4 and 13.5 months in the mFOLFOX-6 and DCF arms, respectively (p=0.72). The rates of hematological toxicity did not differ between the two arms. However, in the subgroup analysis, grade 3-4 neutropenia and febrile neutropenia were significantly more common among patients who had not received G-CSF prophylaxis in the DCF arm. The incidence of grade 3-4 nausea/vomiting and diarrhea were significantly higher in the DCF arm. In conclusion, the present study demonstrated that the efficacy of the mFOLFOX-6 regimen was comparable to that of the DCF regimen in AGC patients. In addition, the benefit of G-CSF prophylaxis in conjunction with the DCF regimen was demonstrated.
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Copy and paste a formatted citation
Spandidos Publications style
Hacibekiroglu I, Kodaz H, Erdogan B, Turkmen E, Esenkaya A, Onal Y, Uzunoglu S and Cicin I: Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer. Mol Clin Oncol 3: 1160-1164, 2015.
APA
Hacibekiroglu, I., Kodaz, H., Erdogan, B., Turkmen, E., Esenkaya, A., Onal, Y. ... Cicin, I. (2015). Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer. Molecular and Clinical Oncology, 3, 1160-1164. https://doi.org/10.3892/mco.2015.592
MLA
Hacibekiroglu, I., Kodaz, H., Erdogan, B., Turkmen, E., Esenkaya, A., Onal, Y., Uzunoglu, S., Cicin, I."Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer". Molecular and Clinical Oncology 3.5 (2015): 1160-1164.
Chicago
Hacibekiroglu, I., Kodaz, H., Erdogan, B., Turkmen, E., Esenkaya, A., Onal, Y., Uzunoglu, S., Cicin, I."Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1160-1164. https://doi.org/10.3892/mco.2015.592
Copy and paste a formatted citation
x
Spandidos Publications style
Hacibekiroglu I, Kodaz H, Erdogan B, Turkmen E, Esenkaya A, Onal Y, Uzunoglu S and Cicin I: Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer. Mol Clin Oncol 3: 1160-1164, 2015.
APA
Hacibekiroglu, I., Kodaz, H., Erdogan, B., Turkmen, E., Esenkaya, A., Onal, Y. ... Cicin, I. (2015). Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer. Molecular and Clinical Oncology, 3, 1160-1164. https://doi.org/10.3892/mco.2015.592
MLA
Hacibekiroglu, I., Kodaz, H., Erdogan, B., Turkmen, E., Esenkaya, A., Onal, Y., Uzunoglu, S., Cicin, I."Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer". Molecular and Clinical Oncology 3.5 (2015): 1160-1164.
Chicago
Hacibekiroglu, I., Kodaz, H., Erdogan, B., Turkmen, E., Esenkaya, A., Onal, Y., Uzunoglu, S., Cicin, I."Comparative analysis of the efficacy and safety of modified FOLFOX-6 and DCF regimens as first-line treatment in advanced gastric cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1160-1164. https://doi.org/10.3892/mco.2015.592
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