Metachronous second primary lung cancer surgically treated five years or more after the initial surgery

Koezuka,Satoshi; Hata,Yoshinobu; Otsuka,Hajime; Makino,Takashi; Tochigi,Naobumi; Shibuya,Kazutoshi; Iyoda,Akira

doi:10.3892/mco.2015.594

September-2015 Volume 3 Issue 5

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September-2015 Volume 3 Issue 5

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Article

Metachronous second primary lung cancer surgically treated five years or more after the initial surgery

Authors:
- Satoshi Koezuka
- Yoshinobu Hata
- Hajime Otsuka
- Takashi Makino
- Naobumi Tochigi
- Kazutoshi Shibuya
- Akira Iyoda
View Affiliations / Copyright

Affiliations: Division of Chest Surgery, Toho University, School of Medicine, Tokyo 143‑8541, Japan, Department of Surgical Pathology, Toho University, School of Medicine, Tokyo 143‑8541, Japan
Pages: 1025-1028
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Published online on: July 1, 2015

https://doi.org/10.3892/mco.2015.594
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Abstract

Surgical treatment for metachronous second primary lung cancer following curative resection of primary lung cancer may be challenging. Standard surgical strategies for metachronous second primary lung cancer have not yet been established. The purpose of this study was to evaluate the outcomes of patients who underwent surgical resection for metachronous second primary lung cancer. A total of 12 patients surgically treated for metachronous second primary lung cancer ≥5 years after the initial surgery were retrospectively analyzed. The overall 5‑year survival after the second surgery was 56.5%. There was no operative mortality. Patients with T1aN0M0 metachronous second primary lung cancer experienced a significantly higher 5‑year overall survival rate compared with other patients (100 vs. 26.7%, respectively; P=0.0336). Among patients who underwent sublobar resection, all 3 patients with T1aN0M0 disease remained alive at the last follow‑up, while 4 of the 5 patients (80%) with non‑T1aN0M0 disease had developed recurrence. Surgery for metachronous second primary lung cancer may be safely performed. Early‑stage metachronous second primary lung cancer was associated with a good prognosis, even among patients who underwent sublobar resection. Early detection of metachronous second primary lung cancer with close long‑term follow‑up following initial surgery may improve surgical outcomes.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Metachronous second primary lung cancer surgically treated five years or more after the initial surgery

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