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Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy

  • Authors:
    • Keiichiro Nakamura
    • Takeshi Nishida
    • Tomoko Haruma
    • Junko Haraga
    • Chiaki Omichi
    • Chikako Ogawa
    • Tomoyuki Kusumoto
    • Noriko Seki
    • Hisashi Masuyama
    • Yuji Hiramatsu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan
    Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1001-1006
    |
    Published online on: July 1, 2015
       https://doi.org/10.3892/mco.2015.595
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Abstract

The aim of the present study was to identify the correlations between inflammation markers such as neutrophil‑lymphocyte ratio (NLR), platelet‑lymphocyte ratio (PLR) and C‑reactive protein (CRP) and the prognosis in patients with recurrent cervical cancer. The associations among NLR, PLR and CRP and clinical characteristics and prognosis were examined in 32 patients receiving chemotherapy with recurrent cervical cancer following concurrent chemoradiation therapy (CCRT). The patient median survival time was 198 days (range, 42‑1,022 days). Pretreatment NLR and PLR were significantly correlated with the recurrence of cervical cancer following CCRT (R=‑0.538, P=0.002; and R=‑0.542, P=0.001, respectively). Pretreatment PLR >322.0 was significantly associated with a poor prognosis for recurrent cervical cancer following CCRT by univariate and multivariate analyses (P=0.015 and P=0.029). These findings indicate that pretreatment PLR is an important predictor of prognosis in patients with recurrent cervical cancer following CCRT.
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Copy and paste a formatted citation
Spandidos Publications style
Nakamura K, Nishida T, Haruma T, Haraga J, Omichi C, Ogawa C, Kusumoto T, Seki N, Masuyama H, Hiramatsu Y, Hiramatsu Y, et al: Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy. Mol Clin Oncol 3: 1001-1006, 2015.
APA
Nakamura, K., Nishida, T., Haruma, T., Haraga, J., Omichi, C., Ogawa, C. ... Hiramatsu, Y. (2015). Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy. Molecular and Clinical Oncology, 3, 1001-1006. https://doi.org/10.3892/mco.2015.595
MLA
Nakamura, K., Nishida, T., Haruma, T., Haraga, J., Omichi, C., Ogawa, C., Kusumoto, T., Seki, N., Masuyama, H., Hiramatsu, Y."Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy". Molecular and Clinical Oncology 3.5 (2015): 1001-1006.
Chicago
Nakamura, K., Nishida, T., Haruma, T., Haraga, J., Omichi, C., Ogawa, C., Kusumoto, T., Seki, N., Masuyama, H., Hiramatsu, Y."Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy". Molecular and Clinical Oncology 3, no. 5 (2015): 1001-1006. https://doi.org/10.3892/mco.2015.595
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura K, Nishida T, Haruma T, Haraga J, Omichi C, Ogawa C, Kusumoto T, Seki N, Masuyama H, Hiramatsu Y, Hiramatsu Y, et al: Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy. Mol Clin Oncol 3: 1001-1006, 2015.
APA
Nakamura, K., Nishida, T., Haruma, T., Haraga, J., Omichi, C., Ogawa, C. ... Hiramatsu, Y. (2015). Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy. Molecular and Clinical Oncology, 3, 1001-1006. https://doi.org/10.3892/mco.2015.595
MLA
Nakamura, K., Nishida, T., Haruma, T., Haraga, J., Omichi, C., Ogawa, C., Kusumoto, T., Seki, N., Masuyama, H., Hiramatsu, Y."Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy". Molecular and Clinical Oncology 3.5 (2015): 1001-1006.
Chicago
Nakamura, K., Nishida, T., Haruma, T., Haraga, J., Omichi, C., Ogawa, C., Kusumoto, T., Seki, N., Masuyama, H., Hiramatsu, Y."Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy". Molecular and Clinical Oncology 3, no. 5 (2015): 1001-1006. https://doi.org/10.3892/mco.2015.595
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