Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer

  • Authors:
    • Takashi Makino
    • Yoshinobu Hata
    • Hajime Otsuka
    • Satoshi Koezuka
    • Kazutoshi Isobe
    • Nobumi Tochigi
    • Nobuyuki Shiraga
    • Kazutoshi Shibuya
    • Sakae Homma
    • Akira Iyoda
  • View Affiliations / Copyright

    Affiliations: Division of Chest Surgery, Toho University School of Medicine, Tokyo 143‑8541, Japan, Division of Respiratory Medicine, Toho University School of Medicine, Tokyo 143‑8541, Japan, Department of Surgical Pathology, Toho University School of Medicine, Tokyo 143‑8541, Japan, Department of Radiology, Toho University School of Medicine, Tokyo 143‑8541, Japan
  • Pages: 1035-1040
    |
    Published online on: July 1, 2015
       https://doi.org/10.3892/mco.2015.596
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intraoperative detection of hilar lymph node metastasis, particularly with extracapsular invasion, may affect the surgical procedure in patients with lung cancer, as the preoperative estimation of hilar lymph node metastasis is unsatisfactory. The aim of this study was to investigate whether fusion positron emission tomography/computed tomography (PET/CT) is able to predict extracapsular invasion of hilar lymph node metastasis. Between April, 2007 and April, 2013, 509 patients with primary lung cancer underwent surgical resection at our institution, among whom 28 patients exhibiting hilar lymph node metastasis (at stations 10 and 11) were enrolled in this study. A maximum lymph node standardized uptake value of >2.5 in PET scans was interpreted as positive. A total of 17 patients had positive preoperative PET/CT findings in their hilar lymph nodes, while the remaining 11 had negative findings. With regard to extracapsular nodal invasion, the PET/CT findings (p=0.0005) and the histological findings (squamous cell carcinoma, p=0.05) were found to be significant predictors in the univariate analysis. In the multivariate analysis, the PET/CT findings were the only independent predictor (p=0.0004). The requirement for extensive pulmonary resection (sleeve lobectomy, bilobectomy or pneumonectomy) was significantly more frequent in the patient group with positive compared with the group with negative PET/CT findings (76 vs. 9%, respectively, p=0.01). Therefore, the PET/CT findings in the hilar lymph nodes were useful for the prediction of extracapsular invasion and, consequently, for the estimation of possible extensive pulmonary resection.
View Figures

Figure 1

Figure 2

View References

1 

Mountain CF: Revisions in the international system for staging lung cancer. Chest. 111:1710–1717. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Rusch VW, Crowley J, Giroux DJ, Goldstraw P, Im JG, Tsuboi M, Tsuchiya R and Vansteenkiste JInternational Staging Committee; Cancer Research and Biostatistics; Observers to the Committee; Participating Institutions: The IASLC Lung Cancer Staging Project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 2:603–612. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Watanabe S, Asamura H, Suzuki K and Tsuchiya R: Problems in diagnosis and surgical management of clinical N1 non-small cell lung cancer. Ann Thorac Surg. 79:1682–1685. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Hishida T, Yoshida J, Nishimura M, Nishiwaki Y and Nagai K: Problems in the current diagnostic standards of clinical N1 non-small cell lung cancer. Thorax. 63:526–531. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Miyasaka Y, Suzuki K, Takamochi K, Matsunaga T and Oh S: The maximum standardized uptake value of fluorodeoxyglucose positron emission tomography of the primary tumour is a good predictor of pathological nodal involvement in clinical N0 non-small-cell lung cancer. Eur J Cardiothorac Surg. 44:83–87. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Steinert HC, Hauser M, Allemann F, Engel H, Berthold T, von Schulthess GK and Weder W: Non-small cell lung cancer: Nodal staging with FDG PET versus CT with correlative lymph node mapping and sampling. Radiology. 202:441–446. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Vansteenkiste JF, Stroobants SG, De Leyn PR, Dupont PJ, Verschakelen JA, Nackaerts KL and Mortelmans LALeuven Lung Cancer Group: Mediastinal lymph node staging with FDG-PET scan in patients with potentially operable non-small cell lung cancer: A prospective analysis of 50 cases. Chest. 112:1480–1486. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Vansteenkiste JF, Stroobants SG, Dupont PJ, De Leyn PR, De Wever WF, Verbeken EK, Nuyts JL, Maes FP and Bogaert JG: FDG-PET scan in potentially operable non-small cell lung cancer: Do anatometabolic PET-CT fusion images improve the localisation of regional lymph node metastases? The Leuven Lung Cancer Group. Eur J Nucl Med. 25:1495–1501. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Hellwig D, Graeter TP, Ukena D, Groeschel A, Sybrecht GW, Schaefers HJ and Kirsch CM: 18F-FDG PET for mediastinal staging of lung cancer: Which SUV threshold makes sense? J Nucl Med. 48:1761–1766. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Carrillo SA, Daniel VC, Hall N, Hitchcock CL, Ross P Jr and Kassis ES: Fusion positron emission/computed tomography underestimates the presence of hilar nodal metastases in patients with resected non-small cell lung cancer. Ann Thorac Surg. 93:1621–1624. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Rusch VW, Asamura H, Watanabe H, Giroux DJ, Rami-Porta R and Goldstraw PMembers of IASLC Staging Committee: The IASLC Lung Cancer Staging Project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 4:568–577. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Detterbeck FC, Boffa DJ and Tanoue LT: The new lung cancer staging system. Chest. 136:260–271. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Vansteenkiste JF, Stroobants SG, Dupont PJ, De Leyn PR, Verbeken EK, Deneffe GJ, Mortelmans LA and Demedts MGLeuven Lung Cancer Group: Prognostic importance of the standardized uptake value on 18F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases. J Clin Oncol. 17:3201–3206. 1999.PubMed/NCBI

14 

Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, et al: Preoperative staging of lung cancer with combined PET-CT. N Engl J Med. 361:32–39. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Silvestri GA, Gould MK, Margolis ML, Tanoue LT, McCrory D, Toloza E and Detterbeck FAmerican College of Chest Physicians: Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest. 132 (Suppl 3):178S–201S. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Ernst A, Eberhardt R, Krasnik M and Herth FJ: Efficacy of endobronchial ultrasound-guided transbronchial needle aspiration of hilar lymph nodes for diagnosing and staging cancer. J Thorac Oncol. 4:947–950. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Shin S, Kim HK, Choi YS, Kim K, Kim J and Shim YM: Prognosis of unexpected and expected pathologic N1 non-small cell lung cancer. Ann Thorac Surg. 96:969–975; discussion. 975–976. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Moreno AC, Morgensztern D, Boffa DJ, Decker RH, Yu JB, Detterbeck FC, Wang Z, Rose MG and Kim AW: Treating locally advanced disease: An analysis of very large, hilar lymph node positive non-small cell lung cancer using the National Cancer Data Base. Ann Thorac Surg. 97:1149–1155. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Watanabe S, Asamura H, Suzuki K and Tsuchiya R: Recent results of postoperative mortality for surgical resections in lung cancer. Ann Thorac Surg. 78:999–1002; discussion. 1002–1003. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Makino T, Hata Y, Otsuka H, Koezuka S, Isobe K, Tochigi N, Shiraga N, Shibuya K, Homma S, Iyoda A, Iyoda A, et al: Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer. Mol Clin Oncol 3: 1035-1040, 2015.
APA
Makino, T., Hata, Y., Otsuka, H., Koezuka, S., Isobe, K., Tochigi, N. ... Iyoda, A. (2015). Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer. Molecular and Clinical Oncology, 3, 1035-1040. https://doi.org/10.3892/mco.2015.596
MLA
Makino, T., Hata, Y., Otsuka, H., Koezuka, S., Isobe, K., Tochigi, N., Shiraga, N., Shibuya, K., Homma, S., Iyoda, A."Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer". Molecular and Clinical Oncology 3.5 (2015): 1035-1040.
Chicago
Makino, T., Hata, Y., Otsuka, H., Koezuka, S., Isobe, K., Tochigi, N., Shiraga, N., Shibuya, K., Homma, S., Iyoda, A."Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1035-1040. https://doi.org/10.3892/mco.2015.596
Copy and paste a formatted citation
x
Spandidos Publications style
Makino T, Hata Y, Otsuka H, Koezuka S, Isobe K, Tochigi N, Shiraga N, Shibuya K, Homma S, Iyoda A, Iyoda A, et al: Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer. Mol Clin Oncol 3: 1035-1040, 2015.
APA
Makino, T., Hata, Y., Otsuka, H., Koezuka, S., Isobe, K., Tochigi, N. ... Iyoda, A. (2015). Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer. Molecular and Clinical Oncology, 3, 1035-1040. https://doi.org/10.3892/mco.2015.596
MLA
Makino, T., Hata, Y., Otsuka, H., Koezuka, S., Isobe, K., Tochigi, N., Shiraga, N., Shibuya, K., Homma, S., Iyoda, A."Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer". Molecular and Clinical Oncology 3.5 (2015): 1035-1040.
Chicago
Makino, T., Hata, Y., Otsuka, H., Koezuka, S., Isobe, K., Tochigi, N., Shiraga, N., Shibuya, K., Homma, S., Iyoda, A."Predicted extracapsular invasion of hilar lymph node metastasis by fusion positron emission tomography/computed tomography in patients with lung cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1035-1040. https://doi.org/10.3892/mco.2015.596
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team