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Article

Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer

  • Authors:
    • Hiroshi Doi
    • Naohito Beppu
    • Takashi Kato
    • Masashi Noda
    • Hidenori Yanagi
    • Naohiro Tomita
    • Norihiko Kamikonya
    • Shozo Hirota
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Surgery, Meiwa Hospital, Nishinomiya, Hyogo 663‑8186, Japan
  • Pages: 1129-1134
    |
    Published online on: July 21, 2015
       https://doi.org/10.3892/mco.2015.604
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Abstract

The purpose of this study was to investigate the clinical value of diffusion-weighted (DW) magnetic resonance imaging (MRI) as a predictor of tumor response in patients receiving neoadjuvant chemoradiotherapy (NA‑CRT) for rectal cancer (RC) through measurement of the apparent diffusion coefficient (ADC) value in each tumor. Neoadjuvant radiotherapy with a total dose of 45 Gy in 25 fractions was performed in all 16 patients with RC, combined with irinotecan and S‑1. MRI was performed before and after NA‑CRT. multiple factors were assessed to predict the pathological response to NA‑CRT. The pathological response rate was determined in 9 patients (56.3%). Statistical analyses indicated that the ADC value prior to NA‑CRT was significantly lower in patients with a better response to NA‑CRT (P=0.023). A cut‑off value of 0.750x10-3 mm2/sec obtained by a receiver operating characteristic curve analysis indicated a sensitivity of 77.8% and specificity of 85.7% for pathological responders to NA‑CRT. In addition, the patients with lower ADC values exhibited a greater pathological response to NA‑CRT (P=0.041). In conclusion, the ADC value of MRI of RC patients treated with NA‑CRT followed by surgery may provide valuable information to predict the response to NA-CRT.
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Copy and paste a formatted citation
Spandidos Publications style
Doi H, Beppu N, Kato T, Noda M, Yanagi H, Tomita N, Kamikonya N and Hirota S: Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. Mol Clin Oncol 3: 1129-1134, 2015.
APA
Doi, H., Beppu, N., Kato, T., Noda, M., Yanagi, H., Tomita, N. ... Hirota, S. (2015). Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. Molecular and Clinical Oncology, 3, 1129-1134. https://doi.org/10.3892/mco.2015.604
MLA
Doi, H., Beppu, N., Kato, T., Noda, M., Yanagi, H., Tomita, N., Kamikonya, N., Hirota, S."Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer". Molecular and Clinical Oncology 3.5 (2015): 1129-1134.
Chicago
Doi, H., Beppu, N., Kato, T., Noda, M., Yanagi, H., Tomita, N., Kamikonya, N., Hirota, S."Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1129-1134. https://doi.org/10.3892/mco.2015.604
Copy and paste a formatted citation
x
Spandidos Publications style
Doi H, Beppu N, Kato T, Noda M, Yanagi H, Tomita N, Kamikonya N and Hirota S: Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. Mol Clin Oncol 3: 1129-1134, 2015.
APA
Doi, H., Beppu, N., Kato, T., Noda, M., Yanagi, H., Tomita, N. ... Hirota, S. (2015). Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer. Molecular and Clinical Oncology, 3, 1129-1134. https://doi.org/10.3892/mco.2015.604
MLA
Doi, H., Beppu, N., Kato, T., Noda, M., Yanagi, H., Tomita, N., Kamikonya, N., Hirota, S."Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer". Molecular and Clinical Oncology 3.5 (2015): 1129-1134.
Chicago
Doi, H., Beppu, N., Kato, T., Noda, M., Yanagi, H., Tomita, N., Kamikonya, N., Hirota, S."Diffusion-weighted magnetic resonance imaging for prediction of tumor response to neoadjuvant chemoradiotherapy using irinotecan plus S-1 for rectal cancer". Molecular and Clinical Oncology 3, no. 5 (2015): 1129-1134. https://doi.org/10.3892/mco.2015.604
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