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Molecular and Clinical Oncology
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September-2015 Volume 3 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy

  • Authors:
    • Nannan Guo
    • Wen Zhang
    • Baoshi Zhang
    • Yingjie Li
    • Jian Tang
    • Shaojun Li
    • Yingnan Zhao
    • Yunlong Zhao
    • Hui Xia
    • Changhai Yu
  • View Affiliations / Copyright

    Affiliations: Medical School of Chinese PLA General Hospital, Beijing 100853, P.R. China, Department of Thoracic‑Cardio Surgery, First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China
  • Pages: 1123-1128
    |
    Published online on: July 21, 2015
       https://doi.org/10.3892/mco.2015.611
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Abstract

Personalizing medicines has refined the traditional treatments for non-small-cell lung cancer (NSCLC). In the present study, efforts towards personalizing delivery of care based on the status of EGFR and K‑RAS mutations, and mRNA expression levels of ERCC1, TUBB3, TYMS, RRM1 and EGFR by choosing appropriate treatments for 52 patients with NSCLC were discussed. Among these 52 NSCLC patients, there were 14 patients treated with gefitinib. Ten patients with EGFR exon 21 point mutations or exon 19 deletions had better treatment outcomes following gefitinib treatment (71.4%). There were 38 patients treated with platinum‑based chemotherapy. Docetaxel‑platinum based chemotherapy was chosen as the first‑line treatment when the patients had low or median ERCC1/TUBB3 expression and gemcitabine‑platinum based chemotherapy was chosen when the patients had low or median ERCC1/RRM1 expression. In total, 26 cases had mRNA expression levels of ERCC1/TUBB3 or ERCC1/RRM1 that could be used to predict the treatment outcomes of chemotherapy (68.4%). The present results indicated that the mutation status of EGFR, as well as the mRNA expression levels of ERCC1, TUBB3 and RRM1, could be used as predictors of the response to gefitinib or chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Guo N, Zhang W, Zhang B, Li Y, Tang J, Li S, Zhao Y, Zhao Y, Xia H, Yu C, Yu C, et al: EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy. Mol Clin Oncol 3: 1123-1128, 2015.
APA
Guo, N., Zhang, W., Zhang, B., Li, Y., Tang, J., Li, S. ... Yu, C. (2015). EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy. Molecular and Clinical Oncology, 3, 1123-1128. https://doi.org/10.3892/mco.2015.611
MLA
Guo, N., Zhang, W., Zhang, B., Li, Y., Tang, J., Li, S., Zhao, Y., Zhao, Y., Xia, H., Yu, C."EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy". Molecular and Clinical Oncology 3.5 (2015): 1123-1128.
Chicago
Guo, N., Zhang, W., Zhang, B., Li, Y., Tang, J., Li, S., Zhao, Y., Zhao, Y., Xia, H., Yu, C."EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy". Molecular and Clinical Oncology 3, no. 5 (2015): 1123-1128. https://doi.org/10.3892/mco.2015.611
Copy and paste a formatted citation
x
Spandidos Publications style
Guo N, Zhang W, Zhang B, Li Y, Tang J, Li S, Zhao Y, Zhao Y, Xia H, Yu C, Yu C, et al: EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy. Mol Clin Oncol 3: 1123-1128, 2015.
APA
Guo, N., Zhang, W., Zhang, B., Li, Y., Tang, J., Li, S. ... Yu, C. (2015). EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy. Molecular and Clinical Oncology, 3, 1123-1128. https://doi.org/10.3892/mco.2015.611
MLA
Guo, N., Zhang, W., Zhang, B., Li, Y., Tang, J., Li, S., Zhao, Y., Zhao, Y., Xia, H., Yu, C."EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy". Molecular and Clinical Oncology 3.5 (2015): 1123-1128.
Chicago
Guo, N., Zhang, W., Zhang, B., Li, Y., Tang, J., Li, S., Zhao, Y., Zhao, Y., Xia, H., Yu, C."EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non‑small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy". Molecular and Clinical Oncology 3, no. 5 (2015): 1123-1128. https://doi.org/10.3892/mco.2015.611
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