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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2015 Volume 3 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Clinical implications of human leukocyte antigen class I expression in endometrial cancer

  • Authors:
    • Kazuyuki Yakabe
    • Akihiro Murakami
    • Yuki Nishimoto
    • Takuya Kajimura
    • Kotaro Sueoka
    • Norihiro Sugino
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan
  • Pages: 1285-1290
    |
    Published online on: September 3, 2015
       https://doi.org/10.3892/mco.2015.636
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Abstract

Decreased expression of human leukocyte antigen (HLA) class I molecules, which is found in several types of cancer, is associated with worse clinical prognosis in cancer patients. The present study was undertaken to investigate the association of immunohistochemical HLA class I expression patterns with clinicopathological factors and prognosis in 96 endometrial cancer patients. HLA class I is composed of a heavy chain (HC-10) and a β2-microglobulin (β2-m) light chain. The HLA class I expression patterns were classified as positive when both HC-10 and β2-m were strongly stained and negative in all other cases. The negative staining pattern was associated with advanced International Federation of Gynecology and Obstetrics stage (p<0.001), lymphovascular space involvement (LVSI) (p=0.003) and lymph node metastasis (p=0.005). Moreover, these cases exhibited worse progression‑free survival (PFS) and overall survival (OS) rates compared with positive cases (p=0.005 and p=0.014, respectively). However, the multivariate analysis did not identify HLA class I expression as an independent predictive factor for PFS and OS. In conclusion, HLA class I expression may be useful for predicting postoperative outcome in endometrial cancer, as well as well-known predictive prognostic factors, such as lymph node metastasis and LVSI.
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Copy and paste a formatted citation
Spandidos Publications style
Yakabe K, Murakami A, Nishimoto Y, Kajimura T, Sueoka K and Sugino N: Clinical implications of human leukocyte antigen class I expression in endometrial cancer. Mol Clin Oncol 3: 1285-1290, 2015.
APA
Yakabe, K., Murakami, A., Nishimoto, Y., Kajimura, T., Sueoka, K., & Sugino, N. (2015). Clinical implications of human leukocyte antigen class I expression in endometrial cancer. Molecular and Clinical Oncology, 3, 1285-1290. https://doi.org/10.3892/mco.2015.636
MLA
Yakabe, K., Murakami, A., Nishimoto, Y., Kajimura, T., Sueoka, K., Sugino, N."Clinical implications of human leukocyte antigen class I expression in endometrial cancer". Molecular and Clinical Oncology 3.6 (2015): 1285-1290.
Chicago
Yakabe, K., Murakami, A., Nishimoto, Y., Kajimura, T., Sueoka, K., Sugino, N."Clinical implications of human leukocyte antigen class I expression in endometrial cancer". Molecular and Clinical Oncology 3, no. 6 (2015): 1285-1290. https://doi.org/10.3892/mco.2015.636
Copy and paste a formatted citation
x
Spandidos Publications style
Yakabe K, Murakami A, Nishimoto Y, Kajimura T, Sueoka K and Sugino N: Clinical implications of human leukocyte antigen class I expression in endometrial cancer. Mol Clin Oncol 3: 1285-1290, 2015.
APA
Yakabe, K., Murakami, A., Nishimoto, Y., Kajimura, T., Sueoka, K., & Sugino, N. (2015). Clinical implications of human leukocyte antigen class I expression in endometrial cancer. Molecular and Clinical Oncology, 3, 1285-1290. https://doi.org/10.3892/mco.2015.636
MLA
Yakabe, K., Murakami, A., Nishimoto, Y., Kajimura, T., Sueoka, K., Sugino, N."Clinical implications of human leukocyte antigen class I expression in endometrial cancer". Molecular and Clinical Oncology 3.6 (2015): 1285-1290.
Chicago
Yakabe, K., Murakami, A., Nishimoto, Y., Kajimura, T., Sueoka, K., Sugino, N."Clinical implications of human leukocyte antigen class I expression in endometrial cancer". Molecular and Clinical Oncology 3, no. 6 (2015): 1285-1290. https://doi.org/10.3892/mco.2015.636
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