Extramedullary blast crisis as initial presentation in chronic myeloid leukemia with the e1a2 BCR-ABL1 transcript: A case report

Ai,Di; Liu,Wei; Lu,Gary; Patel,Keyur  Pravinchandra; Chen,Zi

doi:10.3892/mco.2015.641

November-2015 Volume 3 Issue 6

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November-2015 Volume 3 Issue 6

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Case Report

Extramedullary blast crisis as initial presentation in chronic myeloid leukemia with the e1a2 BCR-ABL1 transcript: A case report

Authors:
- Di Ai
- Wei Liu
- Gary Lu
- Keyur Pravinchandra Patel
- Zi Chen
View Affiliations / Copyright

Affiliations: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Pages: 1319-1322
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Published online on: September 9, 2015

https://doi.org/10.3892/mco.2015.641
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Abstract

A 23-year-old woman presented with enlarged right inguinal lymph nodes. The pathological examination of the nodes revealed infiltration by myeloid sarcoma. A bone marrow smear and biopsy revealed cytogenetic abnormalities, with 46,XX,t(9;22) and chronic myeloid leukemia (CML) was diagnosed. The e1a2 BCR-ABL1 fusion transcript was detected. The patient received imatinib‑based combined chemotherapy, allogeneic hematopoietic stem cell transplantation, donor lymphocyte infusions and dasatinib treatment. The patient achieved complete response and has remained leukemia‑free for >48 months. To the best of our knowledge, this is the first case report of CML with the e1a2 BCR-ABL1 transcript, with extramedullary blast crisis as the initial presentation. The aim of the present study was to discuss this special case with reference to the literature.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Extramedullary blast crisis as initial presentation in chronic myeloid leukemia with the e1a2 BCR-ABL1 transcript: A case report

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Abstract

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